Kleger Lab

Visit the @Klegerlab under kleger-imos.com and consider striving your career with us ! looking forward to receive your applications for PhD and/or postdoc !

As #SarahMerz moves on to a postdoc with #DiegoBalboa at the #UniversityofHelsinki, we are excited to announce that we are recruiting the next generation of PhD students to join our successful team at #IMOS! 🌟 Let’s continue pushing the boundaries of diabetes research together!

A special thanks to #MaureenGannon for summarizing both our studies in a fantastic preview article in #CellReports titled “CUTting through the distance - A disease-relevant long-range ONECUT1 enhancer.” doi.org/10.1016/j.celr… Your support is invaluable!

We also explored in vitro therapeutic options for affected patients and linked a low-frequency variant to type 2 diabetes. Excitingly, the #DanweiHuangfuLab utilized CRISPRi screening during pancreatic differentiation, confirming our findings regarding the same enhancer.Congrats!

Here, we identified a disease-causing deletion upstream of OC1 in compound heterozygosity with an OC1 mutation in an affected individual, while investigating its functional role as a cis-acting enhancer influencing OC1 expression during pancreatic development.

Building on this foundation, we're excited to announce our latest publication in #CellReports! Brilliant #SarahMerz completed her PhD with her second first authorship under the guidance of #SandraHeller, alongside #CecileJulier and me (doi.org/10.1016/j.celr…).

We then discovered that OC1 coding mutations are associated with various forms of diabetes as modeled via pluripotent stem cell differentiation, details in #NatureMedicine (doi.org/10.1038/s41591…).

Our journey began with characterizing the regulatory patterns of ONECUT1 (OC1) during pancreatic lineage commitment, published in #CommunicationsBiology (doi.org/10.1038/s42003…).

🚀 I am thrilled to add another piece to the “ONECUT1 diabetes” puzzle, again with joint forces between the #JulierLab at #INSERM and the collaborative efforts #IvanCosta, the Institutes of #HumanGenetics and #TransfusionMedicine at #UlmUniversity, and other collaborators!

@gscn_office @uni_ulm Well deserved, great job Meike - group leader in the @klegerlab and vice-head of #IMOS !

Congratulation to Meike Hohwieler for the GSCN 2023 Young Investigator Award! She will speak at the GSCN Conference in Ulm on 14 Sept. bit.ly/GSCN-Conferenc… bit.ly/GSCNAwards23 @uni_ulm @KlegerLab #stemcells

Freier Eintritt zur Podiumsdiskussion "Stammzellen - die Alleskönner" mit Wissenschaftler*innen zu Themen von Alterung bis Krebs. Wie ist der Stand der Forschung bei Zelltherapien? Am 15.9. in der vh Ulm. Info: gscn.org/public-resourc… @stadtulm @KlegerLab #stammzellen

Our commenting summary just published in Cell Stem Cell doi.org/10.1016/j.stem…

@CellStemCell It was a pleasure to comment on this important paper from the Wang lab. Cell Stem Cell cell.com/cell-stem-cell…

Pancreatic acinar heterogeneity hijacks carcinogenesis and homeostasis dlvr.it/StCkVV

Great work by the Wang lab: there is much heterogeneity in our beloved pancreas, congrats Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis: Cell Stem Cell cell.com/cell-stem-cell…

Congrats to work by the Wang lab, there is so much heterogeneity in our beloved pancreas! Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis: Cell Stem Cell cell.com/cell-stem-cell…

#klegerlab at kleger-imos.com is hiring again...looking forward to get your applications

@DKG_Berlin @UniklinikEssen @UniklinikUlm @chr_reinhardt @KlegerLab @KlegerLab Congrats Alex!

Deeply honored to receive the prestigious deutscher-krebspreis.de from @DKG_Berlin in the experimental category together with @chr_reinhardt for our work at kleger-imos.com Thanks to the entire @klegerlab @uni_ulm @UniklinikUlm and our friends and collaborators

@r_gross_ Well deserved

Very honored to receive this award, and I’m glad I could share some of my work on EVs! #GfV2023