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Swaminathan Lab
522 posts
Swaminathan Lab
@LabSwaminathan
We are interested in all things cell biology but focused on studying cellular mechanotransduction.
Lund, Sverige Sumali Kasım 2018
398 Sinusundan1.4K Mga Tagasunod
Swaminathan Lab nag-retweet
β1 Integrin-FAK-Piezo1 signalling axis drives in-situ stiffening mediated ECM remodelling and invasion of 3D breast epithelium biorxiv.org/cgi/content/sh… #biorxiv_cellbio
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🚨🚨REMINDER: Tenure-track and generously funded faculty position in "BASIC research into regenerative medicine and disease mechanisms" at our Wallenberg Center for Molecular Medicine (@LuWcmm ) at Lund University (@lunduniversity ).
Swaminathan Lab@LabSwaminathan
🚨📷Be our colleague @lunduniversity!! @LuWcmm is recruiting 2 PIs (see ads below (and in thread)-link corrected) in Regenerative medicine. SO happy to see basic research being prioritised . These are Tenure Track positions with generous start-up packages. lu.varbi.com/en/what:job/jo…
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@lunduniversity @LuWcmm 2nd position in translational research in advanced therapy
lu.varbi.com/en/what:job/jo…
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🚨📷Be our colleague @lunduniversity!! @LuWcmm
is recruiting 2 PIs (see ads below (and in thread)-link corrected) in Regenerative medicine. SO happy to see basic research being prioritised . These are Tenure Track positions with generous start-up packages.
lu.varbi.com/en/what:job/jo…
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Can't wait for Fibronectin, Integrin and Related Molecules (FIRM?) GRC! What a great lineup of speakers - fantastic from @WickstromLab @TanentzapfLab
Tanentzapf Lab@TanentzapfLab
@WickstromLab & myself are happy to announce the program for the upcoming Fibronectin, Integrin & Related Molecules Gordon Research Conference. This is one of the oldest GRC conferences around (since 1982) & we put together an OUTSTANDING program for y'all. Registration is open.
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A beautiful tribute to the memory of Zijie Yan from @aps_unc , Rich Superfine and @UNC community.
unc.edu/discover/carol…
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Fantastic thread on multi-cellular rotations by @onenimesa and @EpiMechFC
epithelial mechanics fan club@EpiMechFC
Collective cell motion has many forms, but rotation is the coolest of them all. I'm @onenimesa, and in this short🧵, I'll highlight some instances of global tissue rotation like this one from @BauschLab
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3. Conformational changes occur at the timescale of milliseconds --crazzzy
4. Summary: outside-in events initiates rapid and coordinated conformation changes which are stabilised by inside-out events and generation of forces to stabilise integrin activation
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so many key points in this study:
1. High affinity extended open binds it ligands slower than its low affinity closed state
2. Force transmitted or tension built across the molecule activates it- making it agnostic to identity of molecules
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" Integrins are molecular machines w/ parts that undergo large, ∼100 Å movements; however, we believed that we could not understand this machine and truly appreciate its soul—its animating principle—until we saw it move. "- Li et al. -What a tour de force
cell.com/cell/fulltext/…
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@InstitutFresnel Coupling this incredible toolkit with the amazing microscope built by @TalonChandler Min Guo, Patrick La Rivière, and Hari Shroff et al. can push the limits of what we know about actin organisation in cells, tissues and model organisms.@mattersOfLight
biorxiv.org/content/10.110…
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Exciting preprint from the awesome folks (Mavrakis & Brasselet group) at @InstitutFresnel on new fluorescent reporters that will allow for polarisation measurements (in addition to regular microscopy) of actin dynamics in live cells!This is a big deal!
biorxiv.org/content/10.110…
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I'm on my way!
TurkuBioscience@BioscienceTurku
Aleksi Isomursu @aisomursu from @IvaskaLab will defend his doctoral thesis "Biomechanics of cancer cell motility" on Friday 12th of April at 12:00 in the Tauno Nurmela auditorium @UniTurku . Aleksi's opponent will be Vinay Swaminathan from Lund University.
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...Alea iacta est....
Just kidding..All the tools involved in these conversations are really amazing..
Robert Haase@haesleinhuepf
Bold statement "Transformers do not outperform Cellpose" by Stringer & Pachitariu 😯 No matter how this controversy ends, this preprint is a fantastic read to learn about good scientific practice in cell segmentation method comparison studies 🤩
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@VickySanzMoreno @jonsson_lab Gosh- More sun than here in the south of Sweden.
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Great work! Also- Someone please set up a **taxis tournament- Single cell type , opposing gradients of same relative magnitudes (how and what?-not sure).. Hapto vs Chemo; Duro vs Curvo; Rheo vs Visco etc. -- Any guesses on winners?
Sylvain GABRIELE@GabrieleSylvain
🚨 How do cells migrate when exposed to curvature cues? We addressed this question using a minimal model developed by Raj Kumar Sadhu & Nir Gov and various curved systems by @LucianoMarine1, @BLadoux and others @PNASNews 👇🏼 pnas.org/doi/10.1073/pn…
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So happy to see this in preprint! Molecular orientation can be a critical property of protein organisation in cells that encodes a wide range of biophysical information that localisation alone can't. To get 3D orientation of molecules in cells in complex environment is exciting!
Talon Chandler@TalonChandler
I’m thrilled to share our preprint: “Three-dimensional spatio-angular fluorescence microscopy with a polarized dual-view inverted selective-plane illumination microscope (pol-diSPIM)”, a new 3D take on fluorescence anisotropy. 🧵1/15 Preprint: ⬇️ biorxiv.org/content/10.110…
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