CENOS St Jude

Driving groundbreaking research at St. Jude’s Center of Excellence in Neuro-Oncology Sciences to advance understanding and improve outcomes for children with #braincancer, including #medulloblastoma, #ependymoma, and #glioma. 🧠🔬 #StJude

The MB-meta Portal--an online tool for exploring predicted survival based on clinical and molecular features--helps guide decisions and supports further research into new treatment strategies. Try it here: proteinpaint.stjude.org/mbportal/ #PediatricCancer #BrainTumorResearch

Scientists at St. Jude published the largest analysis of #medulloblastoma treatment from ~900 patients. By harmonizing clinical & molecular data, they identified new risk groups—enabling more precise, less toxic therapies for kids. ow.ly/XtYs50Xn8cF 🧠✨

We are pleased to welcome Dr. Olivier Ayrault from Institut Curie as a guest speaker for the CENOS-NBTP seminar series presenting "Causal Multi-omics Integration Reveals Metabolic Dependencies in Human Medulloblastoma".

Now published in Genome Biology, this tool demonstrated improved performance compared to 9 existing pipelines: tinyurl.com/munzep9x MOADE is available on GitHub: github.com/jsuncompubio/M…

A new computational method to separate bulk multi-omics data has been developed in collaboration between Qian Li and Paul Northcott’s lab. MOADE can predict cell types and generate personalized molecular profiles for analyzing complex tissues and tumors (1/2).

Alisha Kardian, graduate student in the Mack lab, is the 2025 recipient for the prestigious Schweisguth Prize awarded for the best scientific article by a trainee in pediatric oncology. Congratulations on this outstanding achievement! siop-online.org/schweisguth-pr…

Applications are now open to join the St. Jude Children’s Research Hospital Graduate School of Biomedical Sciences, preparing students to be leaders who transform healthcare outcomes worldwide. Apply today: ow.ly/MsOq50WWYeN

Congratulations to co-first authors Dr. Amir Arabzade and Srinidhi Varadharajan, Dr. Stephan Mack in DNB/CENOS, and Dr. Richard Kriwacki in Structural Biology on the publication of your work!

Droplet-like formation of nuclear condensates underlies how a fusion oncoprotein disrupts gene expression in a form of pediatric cancer. This study spanning disease biology, molecular genetics, and biophysics was published today in Nature Cell Biology. nature.com/articles/s4155…

Ependymoma, the third most common childhood brain tumor, has seen little therapeutic progress in 30+ years. New findings reveal how the ZFTA–RELA fusion protein drives tumor formation via condensates. ow.ly/fg4r50WMPZJ

The Mack lab congratulates Amelia Hancock, a student from the @UniofBath exchange program, for her fantastic presentation on the work conducted during her year-long rotation. She has been an awesome part of the lab and will be greatly missed!

Dr. Stephen Mack, Associate Member of DNB & CENOS, is presenting “Deciphering the molecular and cellular basis of fusion driven ependymoma to uncover novel therapies” for the virtual Science of Childhood Cancer Lecture Aug 21. stjude.org/socc

We are excited to kick off this season of SOCC with a milestone: our 150th lecture. Join us every Thursday, from 8/14 to 11/20, at 12 PM CT / 1 PM ET for an engaging and interactive 15-week virtual lecture series.

The Baker lab had a fantastic experience mentoring POE intern Ethan Wunibald through the summer. He did an excellent job learning an array of techniques in the lab and presenting his findings. We look forward to seeing what he accomplishes next!

The Northcott lab is proud of High School Research Immersion Program student Catherine Carney for her summer research project poster. Your hard work and boundless curiosity was clear in your findings and way you answered tough questions. We know you have a bright future ahead!

A recent study testing CAR-T immunotherapy for ependymoma identified treatment promise and new questions to understand how the immune response can influence treatment response: stjude.org/research/progr…

We appreciate the care and professionalism of the editorial team and referees who oversaw this process. Our Matters Arising highlights the importance of scientific rigor, careful quality control, and cross-validation when handling high-dimensional sequencing datasets.

which we communicated to both the lead corresponding author and the journal. The original paper, along with our re-analysis of this cerebellar dataset, underwent extensive peer review and is now available as a Matters Arising article in Nature. tinyurl.com/2534fr9e

The Northcott lab conducted an extensive re-analysis of a single-cell transcriptional atlas of human cerebellar development originally published in 2022. During this process, we identified significant concerns related to data integrity and interpretation,