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How close are scientists to stopping ALS in its tracks?drugdiscoverynews.com/how-close-are-…
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ShorterLab
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ShorterLab
@ShorterLab
Countering deleterious phase transitions in ALS/FTD, PD, AD, and related disorders @Penn @PennMedicine @bb_upenn @BMBGGUPENN @PGGUPenn @PennNGG @CAMBUpenn
University of Pennsylvania Sumali Ocak 2012
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Transcript diversity reflects deleterious RNA processing errors shaped by population size in metazoans: journals.plos.org/plosbiology/ar…
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Why do we have so many different transcripts? journals.plos.org/plosbiology/ar…
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A gradient green-beard gene in fission yeast: link.springer.com/article/10.103…
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Phase separation of PGL-3 driven by structured domains that oligomerize and interact with RGG motifs: link.springer.com/article/10.103…
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ALS mutations disrupt self-association between the ubiquilin STI1 hydrophobic groove and internal placeholder sequences: link.springer.com/article/10.103…
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Protein overabundance is driven by growth robustness | Science Advances science.org/doi/10.1126/sc…
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Happy first day of Spring, Philly. 🌷🌸
Pretty soon, our City will be looking like this!
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Membrane-associated Rhes-Slc4a7 complex orchestrates tunneling nanotube formation and mutant Huntingtin spread | Science Advances science.org/doi/10.1126/sc…
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Amino acid composition drives aggregation during peptide synthesis: nature.com/articles/s4155…
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We've made it through winter, happy spring equinox! 🌷🐝
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Small heat shock proteins HspB1 and HspB5 differentially alter the condensation and aggregation of the TDP‐43 low‐complexity domain - Walker - 2026 - Protein Science - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/pr…
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It turned out to be an absolutely beautiful night on the Schuylkill River
Jimmy King@Jimmyking35
I could write a book on good spots to relax in the city of Philadelphia
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Somatic gene mutations in the motor cortex of patients with sporadic amyotrophic lateral sclerosis: academic.oup.com/brain/article/…
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The Hsp40 cochaperone DNAJC7 regulates polyglutamine aggregation and exhibits context-dependent effects on polyglycine aggregation - Journal of Biological Chemistry jbc.org/article/S0021-…
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HIV-1-encoded circular RNA enhances viral transcription through Tat binding: nature.com/articles/s4156…
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Paraspeckle condensation is controlled via TDP-43 polymerization and linked to neuroprotection: nature.com/articles/s4155…
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How could you not love this city, man
Jimmy King@Jimmyking35
I could write a book on good spots to relax in the city of Philadelphia
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(Lnc)ing MALAT1-SRSF1 condensates to hypoxia-induced RNA alternative splicing and cancer: Molecular Cell cell.com/molecular-cell…
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Simultaneous spatial transcriptomics and morphology profiling as tools to explore how microglia change with age: nature.com/articles/s4358…
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