Therapeutic Advances in Infectious Disease

Case report: in HIV patient with recurrent Cryptocccal meningitis 🧠 despite virologic suppression, re-induction + isavuconazole led to immune recovery, viral control, and no further CM episodes over 6 months journals.sagepub.com/doi/full/10.11…

Chronic pulmonary aspergillosis + pulmonary embolism = a challenging duo 🫁🦠🩸Mechanisms may include inflammation + endothelial damage 🧬Management is tricky—anticoagulation vs hemoptysis risk ⚖️journals.sagepub.com/doi/full/10.11…

P: Mild COVID-19 pneumonia 🦠 I: Clarithromycin 800 mg/day 💊 C: Standard of care O: No significant change in time to 50% symptom improvement, but ↓ fatigue and ↓ inflammatory cytokines. Signals of immunomodulation worth further study. 🔬 journals.sagepub.com/doi/full/10.11…

Contingency management isn’t just for abstinence.A harm-reduction clinic for people who use drugs used incentives to encourage risk assessment, testing, clinic engagement to reduce HIV and infection risk.Early results show engagement among patients. journals.sagepub.com/doi/full/10.11…

In a survey of women in 🇿🇦 younger women& those engaged in transactional sex were more likely to intend to use PrEP, while condom users were less likely. #HIVPrevention #PrEP journals.sagepub.com/doi/full/10.11…

Strongyloides hyperinfection can occur without eosinophilia—even with CD4 >500 and undetectable HIV viral load. Early diagnosis is lifesaving ⚠️ journals.sagepub.com/doi/full/10.11…

Invasive pulmonary aspergillosis remains a lethal threat in immunocompromised and post-COVID patients 🦠 Advances in PCR, lateral flow assays, and immuno-PET/MRI are reshaping diagnosis, but rising azole resistance demands susceptibility testing journals.sagepub.com/doi/full/10.11…

In this systematic review (29 studies), mNGS outperformed culture for spinal infections with broader pathogen detection,higher sensitivity,faster turnaround⏱️ Challenges remain: cost & distinguishing colonization from infection. journals.sagepub.com/doi/full/10.11…

Peptide-based vaccines are redefining precision immunology, offering safety, specificity,scalable manufacturing. This review explores how bioinformatics-driven epitope design, nanoparticles,& next-gen adjuvants are fighting viral threats 🚀🦠journals.sagepub.com/doi/full/10.11…

Ticks strike twice 🐜🐜 Fatal Babesia microti/Borrelia burgdorferi coinfection presenting as acute liver failure and shock. Read full case @ journals.sagepub.com/doi/full/10.11…

🦠 Rare but severe: necrotizing gingival & sinus infection due to Trichoderma longibrachiatum in an allo-HSCT recipient. Cure achieved with aggressive surgery 🔪 + combination antifungals 💊, including consolidation with rezafungin. journals.sagepub.com/doi/full/10.11…

Febrile neutropenia still drives heavy carbapenem use due to MDR Gram-negatives. In a cohort of 553 FN episodes, an ML risk model + prior colonisation data could cut meropenem use by ~30% and IEAT from 23% to 9%, supporting personalised EAT. journals.sagepub.com/doi/full/10.11…

Chronic pulmonary aspergillosis can complicate pulmonary echinococcosis via residual lung cavities. In this review (41 studies, 72 CPA cases), diagnosis relied on radiology/histology, combined surgical–medical therapy led to uniformly favorable outcomes journals.sagepub.com/doi/full/10.11…

🦠⚠️ Rising MDR in cUTIs demands new options. Plazomicin shows strong in-vitro activity, synergy with key agents, and favorable outcomes in trials—yet real-world evidence from LMICs is urgently needed 📉📊. journals.sagepub.com/doi/full/10.11…

Imidazolopiperazines (KAF156/ganaplacide) show potent activity across blood, liver, and gametocyte stages of Plasmodium 🦟💊—a promising path forward as antimalarial resistance rises. journals.sagepub.com/doi/full/10.11…

🚨 Submission Open! 🚨 🦠 Antimicrobial Resistance Mechanisms & Therapeutic Options for Difficult-to-treat Nosocomial Pathogens 🌍 📅 Deadline: Dec 31, 2025 📚 Submissions are now welcome! For full details, check out the link. journals.sagepub.com/topic/collecti…

🧬 Unusual infection: M. luteus, normally a skin commensal, triggered prosthetic valve endocarditis in an immunocompetent woman. 8 weeks of IV vancomycin led to full recovery. journals.sagepub.com/doi/full/10.11…

📊 New study from Teso, Uganda: Among 1009 TB patients, overall treatment success was 91.9%. Females had higher success, while age >49 and HIV infection lowered success. Early screening, preventive therapy, and peer support are key to improving outcomes. journals.sagepub.com/doi/full/10.11…

🚨 Submission Open! 🚨 🦠 Antimicrobial Resistance Mechanisms & Therapeutic Options for Difficult-to-treat Nosocomial Pathogens 🌍 📅 Deadline: Dec 31, 2025 📚 Submissions are now welcome! For full details, check out the link. journals.sagepub.com/topic/collecti…

Antipseudomonal beta lactams yielded outcomes similar to cefazolin/oxacillin in this study of of MSSA bacteremia.However there were more complicated infections in the SOC arm.These data may inform antibiotic choices when broad coverage is needed. journals.sagepub.com/doi/full/10.11…