Walker Neuro Lab

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Walker Neuro Lab

Walker Neuro Lab

@WalkerNeuroLab

Neurodegeneration Pathobiology Lab studying TDP-43, on a mission to cure #MND #ALS & #FTD. Led (and most tweets) by @adamkeithwalker. @QldBrainInst, @UQ_News.

Beautiful Brisbane, Australia Sumali Mart 2017
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Walker Neuro Lab
Walker Neuro Lab@WalkerNeuroLab·
Very happy to see our collaborative project led by @Rebecca_SanGlia with @adamkeithwalker out today in @NatureComms, tracking proteomic changes in the cortex throughout disease in TDP-43 mice with comparison to human #ALS #FTD doi.org/10.1038/s41467…
Rebecca San Gil@Rebecca_SanGlia

TDP-43-mediated neurodegeneration is complex. We show that prior to disease onset in a mouse model of ALS/FTD, cortex neurons elicit a transient increase in protective chaperones that combat TDP-43 aggregation. Read it @NatureComms: rdcu.be/dy1PM

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Dehorter Lab
Dehorter Lab@DehorterLab·
The @dehorterlab is excited to share a new study demonstrating a causal link between #immune activation, #alphasynuclein and #Parkinson onset. This work establishes the first immune-induced model to investigate the prodromal phase of idiopathic #Parkinson. @QldBrainInst @JCSMR
bioRxiv Neuroscience@biorxiv_neursci

Alpha Synuclein Induced Immune Response Triggers Parkinson's Disease Like Symptoms biorxiv.org/cgi/content/sh… #biorxiv_neursci

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Natalie Farrawell
Natalie Farrawell@NatalieFarrawe1·
Today would have been Justin's 50th birthday, but as many of you know, Justin passed away last year after a long battle with MND This weekend the Yerbury lab are taking part in the walk to defeat MND to raise vital funds to support those living with MND ⬇️ walktodefeatmnd.org.au/fundraisers/Na…
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MND Research Australia
MND Research Australia@MND_RIA·
SAVE THE DATE! We will be holding the 3rd Australian and New Zealand MND Research Symposium in Melbourne on Tuesday 27th and Wednesday 28th of August. An MND Connect session will also run on the Wednesday. Further information to come as we progress with the event.
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Walker Neuro Lab
Walker Neuro Lab@WalkerNeuroLab·
This is sad news on the outcomes of the pivotal phase 3 trial of AMX0035, which did not meet any of the primary or secondary outcome measures for people living with ALS/MND. Next steps unclear, but there are many more treatments in testing which will hopefully be more positive.
Amylyx@AmylyxPharma

Today, we shared the topline results from our Phase 3 PHOENIX trial. Read more in our press release: bit.ly/3TbILMC On behalf of the entire Amylyx team, we are grateful to the ALS community and for the dedication of trial participants, investigators, and study site teams. With data collected from 664 participants in PHOENIX, we are certain there will be important learnings that will help inform future ALS research.

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Queensland Brain Institute, UQ
Queensland Brain Institute, UQ@QldBrainInst·
"We found several proteins that were driving disease forward and making it worse... we also found proteins that are increased early in disease and are protective." @QldBrainInst researcher @Rebecca_SanGlia explains how her protein map could offer therapeutic pathways for #MND.
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Walker Neuro Lab
Walker Neuro Lab@WalkerNeuroLab·
Very happy to see our collaborative project led by @Rebecca_SanGlia with @adamkeithwalker out today in @NatureComms, tracking proteomic changes in the cortex throughout disease in TDP-43 mice with comparison to human #ALS #FTD doi.org/10.1038/s41467…
Rebecca San Gil@Rebecca_SanGlia

TDP-43-mediated neurodegeneration is complex. We show that prior to disease onset in a mouse model of ALS/FTD, cortex neurons elicit a transient increase in protective chaperones that combat TDP-43 aggregation. Read it @NatureComms: rdcu.be/dy1PM

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FrattaLab
FrattaLab@FrattaLab·
Want to deliver gene therapies broadly, but activate them only in diseased neurons? TDP-REG "hacks" TDP cryptic mis-splicing to drive expression only WHEN and WHERE needed! Less toxicity, wider therapeutic window, new options for sporadic ALS therapies. biorxiv.org/content/10.110…
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Walker Neuro Lab
Walker Neuro Lab@WalkerNeuroLab·
Thank you to @FightMND and all the supporters for giving a thumbs up to our new collaborative project @QldBrainInst with @adamkeithwalker @samkbarton7 @Rebecca_SanGlia @DrCarlieCullen @DrCathBlizzard and co! We are eager to get started!
FightMND@FightMND

Introducing our third grant recipient of 2023, Dr. @adamkeithwalker from @UQscience. His project ‘Oligodendrocytes and TDP-43 pathology in MND' aims to unlock the causes and disease mechanisms of MND. We're so lucky to support the best and brightest researchers in Aus.

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FightMND
FightMND@FightMND·
Join us on 24 October at 12pm AEDT to hear about how patient registries are helping to accelerate clinical discoveries in MND research. Register at: fightmnd.org.au/fightmnd-scien…
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Tuklasin

@DehorterLab @QldBrainInst @JCSMR @AmyBrodtmann @PennMedicine @Rebecca_SanGlia @MND_RIA @FightMND