
SPRK
2.4K posts

SPRK nag-retweet

BIIB080 floods the cortex but barely reaches the hippocampus.
$ARWR ARO-MAPT goes subcutaneous through the transferrin receptor and hits the deep brain uniformly.
Same target. Better real estate.
New paper on the 2H2026 readout setup, now on Substack:
bioboyscout.substack.com/p/aro-mapt-the…
English
SPRK nag-retweet
SPRK nag-retweet


I’d like to the NHL Player Safety for not suspending Jamie Benn.
There was a lot of attention on Benn in this series for his cheap plays, but man what a horrendous series for the #TexasHockey cap’n.
6 Games:
0 goals
0 assists
0 points
-7
#mnwild
English
SPRK nag-retweet

$ARWR trades at over $10B today.
If ARO-MAPT's Phase 1 reads positive in 2H 2026, the math says it's worth $55-$90B to a strategic acquirer.
Not a guess. Four independent methodologies. Same range.
Full paper: drive.google.com/file/d/1D5eD6Y…
English
SPRK nag-retweet
SPRK nag-retweet

SPRK nag-retweet
SPRK nag-retweet
SPRK nag-retweet

SPRK nag-retweet
SPRK nag-retweet
SPRK nag-retweet
SPRK nag-retweet

SPRK nag-retweet
SPRK nag-retweet

$IOVA
has 4 big near-term catalysts that could ignite serious upside:
Tandem Meetings 2026 Real-World Data Drop
New real-world evidence on Amtagvi in advanced melanoma (building on strong ~49% ORR commercial data).
Q4 2025 Earnings + 2026 Guidance
Expected Feb 26, 2026. With 2025 revenue guidance reaffirmed at $250-300M and >1,000 patients treated, look for accelerating sales, margin gains from in-house manufacturing, and potentially upbeat 2026 outlook to spark a rally.
Endometrial Cancer Results (IOV-END-201)
Initial data from Phase 2 in advanced endometrial cancer (post-PD-1) on track for early 2026. Huge unmet need—no approved options here—positive readout could unlock a new major indication and expand the platform massively.
IOV-4001 (PD-1 Knockout TIL) Results
Clinical results in previously treated advanced melanoma expected Q1 2026. This next-gen engineered TIL could show boosted efficacy over standard—
English
SPRK nag-retweet
SPRK nag-retweet
SPRK nag-retweet
SPRK nag-retweet













