The Bianchi Lab

Our paper in @ScienceAdvances. The loss of a ClC anion channel increases life span, health span, and stress resistance by alkalinizing a pair of glial cells in C. elegans #aging #Huntington #stress #alkalinity #glia #autophagy #ionchannel #pH science.org/doi/10.1126/sc…

Glia-to-Axon Transfer of Ribosomes and miRNAs: A Novel Paradigm in Neural Repair "Schwann cell-derived exosomes thus represent both a novel mode of glia–neuron communication and a promising avenue for next-generation therapies for nerve regeneration." onlinelibrary.wiley.com/doi/10.1111/jn…

Becoming a parent is much more detrimental to women’s academic careers than it is to men’s Read the full story: go.nature.com/4v0XLiz

Collagen gene expression is linked to aging and lifespan extension in C. elegans sciencedirect.com/science/articl…

iGABASnFR2 is an improved genetically encoded protein sensor of GABA elifesciences.org/articles/10831…

Online now: Lysosomal salvage of neuronal lipids enables glial infiltration of synaptic regions dlvr.it/TRhd7K

New! Online now: Mitochondrial lactate venting limits oxidative stress dlvr.it/TRgqtQ

The expanding role of mitochondria–lipid droplet contacts in liver and their disruption by MASLD dlvr.it/TRfr3g

Ketogenic diet dampens excitatory neurotransmission by shrinking synaptic vesicle pools cell.com/cell-reports/f…?

Mitochondria acidify lysosomes through membrane contacts @uofcincy @SunLabUCin sciencedirect.com/science/articl…

Mitochondria acidify lysosomes through membrane contacts dlvr.it/TRYh7H

As mice age, changes in the microorganisms in their guts contribute to cognitive decline by altering signalling between the gut and brain go.nature.com/4lsLwH9

Nature research paper: Intestinal interoceptive dysfunction drives age-associated cognitive decline go.nature.com/4urQCHN

Dr. Leonard Petrucelli has joined the Miller School of Medicine as Founding Director of the Neuroscience Institute. Dr. Petrucelli is a visionary scientist and a global leader in neurodegeneration research. His seminal work has uncovered the molecular mechanisms underpinning Alzheimer’s disease, frontotemporal dementia and ALS. His research reveals novel biomarkers and therapeutic targets that will help shape the next generation of treatments, helping to improve the lives of patients facing these devastating diseases. Welcome, Dr. Petrucelli! Read more: loom.ly/xQNlf4M

Cross-Organ Mitochondrial Communication in Stress and Disease annualreviews.org/content/journa…

Online now: Astrocytic H3 receptors regulate anxiety through GABA signaling dlvr.it/TRK0cz

PIEZO2—unlike PIEZO1—is tethered to the actin cytoskeleton, enabling sensory neurons to detect localized mechanical forces such as light touch. Findings reported in @Nature from the lab of Ardem Patapoutian @ardemp link nanometer-scale imaging to sensory function. More: ow.ly/gJ1p50YpWBR

Pacinian corpuscles detect vibration, right? No. What they actually detect is stimulus velocity, and vibration sensitivity is just a consequence. A new study from our lab by Akitoshi Chikamoto and Melissa Meng: rdcu.be/e6Dbr

Exercise prevents brain ageing and memory loss by strengthening the blood–brain barrier go.nature.com/4aWiZVO

Adenosine signaling driven by the gut microbiota underlies chronic alcohol-induced anesthetic resistance dlvr.it/TR43FL

"Mislocalization of KCNQ2 Channels as a Pathogenic Mechanism in KCNQ2 Developmental and Epileptic Encephalopathy" jneurosci.org/content/46/3/e…