Dougan Lab

Molecular mechanisms of mitochondrial AAA+ proteases - Journal of Biological Chemistry jbc.org/article/S0021-…

Chemical activation of mitophagy via the N-degron pathway alleviates mitochondrial neuropathies biorxiv.org/content/10.648…

Data-Driven Design of PROTAC Linkers to Improve PROTAC Cell Membrane Permeability | JACS Au pubs.acs.org/doi/10.1021/ja…

Molecular mechanisms of mitochondrial AAA+ proteases - Journal of Biological Chemistry jbc.org/article/S0021-…

Our recent work on mechanism of disassembly and reassembly of oligomeric proteins is now published in ACS Biochemistry. doi.org/10.1021/acs.bi…

CLIP-LUX: A Luminescent Split-Ubiquitin Assay Using ClpS-Mediated N-Degron Recognition for Detection of Protein-Protein Interactions in Mammalian Cells. sciencedirect.com/science/articl…

Elongation Factor Tu Acts as a Chaperone to Activate an Antibacterial RNase Toxin - goo.gl/scholar/WFsfuJ #ScholarAlerts

Online Now: Mitochondria as sources and targets of cellular signaling dlvr.it/TQcy31

Metabolically regulated proteasome supramolecular organization in situ: Cell cell.com/cell/fulltext/…

Online Now: Ribosome-NAC collaboration: A regulatory platform for cotranslational chaperones, enzymes, and targeting factors dlvr.it/TQbRjK

The ribosome synchronizes folding and assembly to promote oligomeric protein biogenesis sciencedirect.com/science/articl…

In @eLife: Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (PROTAC) doi.org/10.7554/eLife.…

Structural landscape of the degrading 26S proteasome reveals conformation-specific binding of TXNL1: nature.com/articles/s4159…

How's your juggling act? Mitochondria also have one, and the MITOtalk this week will be all about it. See you there?

Mechanisms of assembly and function of the Hsp70-Hsp40 chaperone machinery sciencedirect.com/science/articl…

Online Now: Delayed protein translocation protects mitochondria against toxic CAT-tailed proteins dlvr.it/TNnWzh

Proteolytically activated antibacterial toxins inhibit the growth of diverse gram-positive bacteria pnas.org/doi/abs/10.107…

The yeast peroxisomal proteome at absolute quantitative scale biorxiv.org/content/10.110…

Hsp110 nucleotide exchange factors may amplify Hsp70-disaggregation by enhanced entropic pulling. sciencedirect.com/science/articl…

Structure of a distinct β-barrel assembly machinery complex in the Bacteroidota 別グループからも出てる nature.com/articles/s4156…