Nick Raney
841 posts


@McMasterDaily 1) its krytox, flurochemical wizards. 2) high temp, has some exotic thickeners 3) niche market, low volume 4) not edible but has approval for incidental contact at best
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@duncanstives @cameron62s even more wild is they designed for that leakage at STP
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@cameron62s They didn't have CAD let alone text to CAD AI... Maybe that's why it leaked fuel all the time 🤔
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@DuchessVonD Writing, like recovery, is all about findng the right dose n stayin in the therapeutic window - looks like your well on your way to steady state greatness! Keep metabolizing those experiences n eliminate the doubt. The world needs your compound in circulation!
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@DuchessVonD Dee! Im just seeing this somehow. Your words hit like a sweet (for my tastes) C-T curve --Slow release, maximum effect. Im honored I could be a bit of excipient in your formulation, helping the active (you) do its thing. (cont.)
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21 Grams of Fentanyl To Remember You By
The year draws to a close, and the ritual of taking stock begins. Not of inventory, not of profit margins, but of the faces that still grace this mortal coil. A grim audit of survival. For some, loss is a distant echo, a faded photograph in a dusty album. For me, it's a constant companion, a phantom limb that aches with every passing day. In the opioid game, intimacy arrives with brutal speed. Your confidantes become casualties. Your allies turn to whispers in the shadows, trading loyalty for a fix, or worse, a deal with the devil in blue.
The streets are paved with broken promises and the ghosts of those who OD'd in trap houses. You think you're clever, a puppet master pulling the strings of fate, mastering the alchemy of oblivion. Like that professor in "Candy," you delude yourself into believing you're bringing solace, a temporary reprieve from the crushing weight of existence. But the truth, a bitter pill I’ve swallowed countless times, is this:
Everybody was my friend… until they became my customer.
The Illusion of Control
I could give it away. I did give it away, countless times. Late nights, backroom deals, "hooking a brotha up"—gestures of misplaced generosity, desperate attempts to blur the lines between friend and client. But the truth remained, etched in the haunted eyes of those who came to me: I wasn't a friend. I was the gatekeeper. The one who held the key to their fleeting euphoria, and, unknowingly, to their eventual ruin.
I told myself I was controlling the market, a benevolent drug lord setting fair prices, ensuring a steady supply. “I’m the market,” I’d whisper to the empty rooms, a pathetic mantra of self-justification. I wasn’t some Bindle 'N Bundle Bernanke, manipulating interest rates of misery. I was the architect of their dependence, the engineer of their destruction.
Where are they now, those faces from 2006, 2007? The ones who laughed with me, shared secrets, dreams? Gone. Vanished like smoke in the wind. Robert Graves had it right: "Goodbye to All That."
It’s not the abstract guilt of contributing to a national crisis that haunts me. It’s the personal toll, the faces I can no longer see, the voices I’ll never hear again.d It’s the first cut, the deepest, the one that sets the pattern for all the others. It’s the way relativity twists the knife: the closer they were, the sharper the pain. What does it mean to know that something you created, this fire you unleashed, reached out and consumed those closest to you? That’s my story. A cautionary tale for anyone who dreams of playing El Chapo with the universe.
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December 29, 2004
Before I was fully initiated into this brotherhood of selling suffering wholesale to gangs and distros, I knew its sting. My cousin, just two years older, a whirlwind of restless energy, had barely tasted freedom after a stint in county jail. His "Booster Bragging Rights"—a juvenile escapade involving a stolen encrypted radio, an AR15 from a police cruiser, a military armory and stolen Javelin rocket launchers—had landed him there. Now, he was back, trying to find his footing, trying to outrun the demons that clung to him like shadows. He was working his way back up to 80 mg of Oxy, chasing the phantom of oblivion. That afternoon, he scored 40 mg of Methadone. One tablet. One dose. One fatal arrhythmia.
I was seventeen, a kid playing adult in a world I didn’t understand. My dad, bless his practical soul, had made sure we were all lifeguard certified. I knew CPR. I remember the frantic compressions, the forced breaths, the "Ice Queen"—my aunt Theresa—taking over, her face a mask of frozen terror. I remember his saliva, still warm on my lips. He was gone. His bowl of cheerios lying spilled onto the floor. Leaking out, like his life force. Just like that. The weight of his lifeless body in my arms, the echo of his last breath, the image of his eyes, fixed and vacant—these are the memories that claw at me in the dead of night.
The train of devastation, the Fentanyl Zephyr, a phantom express carrying the weight of all my sins wasn't finished with me. It never is. It’s a ghost train that circles back like a celestial orbit, its mournful whistle echoing through the desolate landscape of my heart. It doesn't care about calendars or celebrations; it operates on its own cruel timetable. Years later, under the oppressive weight of another December night, it pulled into Deandra Station again, bringing with it another cargo of grief.
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December 8, 2011
A decade later. Another December. Another loss. Today is a day I try to erase from the calendar, a black hole in the fabric of time. The 1975’s “Somebody Else” plays on some random radio station and it all comes rushing back.
The memory of his last kiss, the cold saliva on even colder lips. That morning, he’d texted me, full of life, talking about steak dinners and my upcoming birthday. I’d sent him back a Gwen Stefani lyric, a desperate, unspoken plea: I’d kill a dozen Santa Clauses, steal his sleigh, and come back home to you. A hollow promise in retrospect.
That night, I came home to beef brisket cooking in the crock pot. My favorite. He knew me so well. I called his name a few times as I began to prepare the green beans. 15 mins passed, no response. Maybe he has his headphones on playing Call of Duty in the man cave? I went to check. No dice. So I wandered back upstairs, drawn to the dark corridor near the back of our quaint brownstone, a light shining through an open bedroom door.
And that's where I found him. Lifeless. No breaths. No pulse. Cold, clammy skin. The frantic 911 call, the chest compressions, the Narcan, the Doxapram—a desperate, futile dance with death. How much epi in a code? My mind screamed, but the knowledge was useless, a cruel mockery in the face of the inevitable. I had a literal pharmacy at my fingertips in my medic bag, but all the king's potions can't bring my Humpty back. I held him, tears streaming down my face, mingling with the coldness of his skin. Blue Lips, Pale Fingertips. The whispers began, the same insidious voices that haunted Hamlet, echoing in my mind: You’re too late. You’re too late. You’re too late.
The contents of the safe, the evidence of my trade, went into a garbage bag. A ritual of destruction, a desperate attempt to erase my culpability. The charcoal briquettes, the lighter fluid, the match—a moth drawn to the flame of my own guilt.
Twenty-one grams of fentanyl, reduced to ash, rising like a macabre phoenix from the flames, a twisted echo of Sadako's paper cranes, carrying his soul away from me, away from the world I had helped to destroy.
When my time comes, will there be a Ferryman willing to guide this wretched soul across the River Styx? Or will I be left to wander the shores of regret, haunted by the faces of those I’ve lost, forever trapped in the echo of their last breaths?
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@deepwebslinger steam distilled frankincense contains no boswellic acid , the anxiolytic component does not steam distill
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@EthicalSkeptic I had a mycoplasma infection, not this current one. Nothing touched it (azithro, etc). Then I had the bright idea to use a micro stim device. It was dead in 3 days. What kills viruses (& presumably fungi)? Heat, electricity, uv light. Hard to get uv light in the lungs, so …
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@DuchessVonD @charbo187 LOL! Please tell me this bit on Epsteins (not kosher enuff) Dolphins is real
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Mark Twain wrote an entire book on it. "Huckleberry Finn" was the title. About a mixed race of dolphins that Jeffrey Epstein rejected on account they were not 'kosher' enough to enter into the paradise of his islands. so they made their own conclave near what is now Disney Land. Secretly relaying the gift of love and reproduction to the millions of youth that visit that beach of regret, each year.
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@DuchessVonD was my issue with measure110 in PDX. it didnt decrim local production, so supply was left up to big corp cartels selling McDonalds type drugs. Now, theres a generation who thats all they know, shit tier rugs.
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@DuchessVonD Heroin gave us alot culturally. The fent folk dont seem to be doing much at all. So its really a net negative societal cost imo waiting for someone to show me the art or music etc that the current shit tier drugs are helping create.
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STRUCTURE-EUPHORIA RELATIONSHIPS IN THE OPIOID CLASS
I've been studying the structure-activity relationships (SAR) of pharma opioids and obscure experimental varieties for the past 14 yrs with a keen interest in the relationship between structure and euphoria. Euphoria often leads to a more "abuse" prone opioid, but also contributes greatly to the analgesic effect. When pain patients feel better they don't mind the underlying pain.
As a pharma chemist, drug connoisseur, and CPP myself, I've been self-experimenting with a plethora of opioids over the years and gathered a great deal of user feedback from others who use opioids. I've concluded that the analgesic phenomenon and the euphoric 'side-effects' are inextricably paired. Nobody should feel guilty for seeking relief. And no patient should be script shamed for feeling euphoria.
**Note: The word 'abuse' is often confused with patients who are self-medicating outside of legit medical channels.
As euphoria is a highly subjective phenomena, the enclosed rank-order list of opioid euphoriants should not be relied upon as a guide for medical treatment or discourage any physician from prescribing a particular opioid.
This list applies only to opioids which myself and two other subjects (i.e. 'The Itty Bitty 31-Gauge Needle Committee') have experienced, the order being decided by vote. This inclusion criteria has ruled out an additional 30 opioid agonists of an obscure nature that I've made and consumed exclusively by myself.
To help demonstrate it's clinical limitations, let's examine the top three mu agonists from this list. Both dextromoramide and dimethylmoramide provide top-shelf euphoria, but this comes at the cost of a very short duration of action (90 mins), leading to chronic redosing, waking up every few hrs to redose, and rapid tolerance escalation. As such, the moramides have little clinical value.
Third ranked isomethadone is structurally related to the moramide family as part of the same alpha-methyl diphenylpropylamine superfamily and shares the same stereochemistry about alpha-carbon: the majority of its narcotic analgesia is attributed to the (R)-isomethadone and the (R)-dextromoramide isomers.
As with the moramide family, isomethadone is a top-shelf euphoriant. The euphoria of the moramides and isomethadone are nearly indistinguishable, the primary difference being that isomethadone provides potent euphoria and analgesia for up to 12-18 hrs, compared to 1.5 hrs for the moramides. This extended duration of action makes isomethadone a top-shelf analgesic and maintenance medication.
Isomethadone was the first fully synthetic opioid to be withdrawn from the market b/c of its euphoric effects and the fears of 1950s medicine that this would lead to "addiction." During this bygone era, the 'physical dependence capacity' of a narcotic could be determined by human testing on former heroin addicts. These studies, conducted primarily by a single investigator, Harris Isbell, at what was then the only drug rehab center in the United States, showed that isomethadone was preferred overwhelmingly over heroin and morphine by the test subjects (former heroin users). Dextromoramide was de facto removed from the market about 15 years ago when its single manuf. discontinued the drug, which had long fell out of favor by even the most wacky European doctors.
The rapidly developing 'designer opioid' or 'RC opioid' scene coming primarily out of China is a shitshow that I've tried my best to avoid. I've sampled a scarce few of the nearly 20 nitazene opioids that have appeared on the designer market since isotonitazene was introduced in March 2019. These 2-benzylbenzimidazole opioids related to etonitazene are bottom-rung euphoriants that have a notoriously narrow therapeutic index (slim safety margin), resulting in profound respiratory depression with minimal euphoric reward. Recent in vitro and in vivo studies of the nitazenes have revealed that they exert mutagenic/teratogenic effects and have profound cardiotoxicity at clinically relevant doses via inhibition of the cardiac hERG channel. My lack of curiosity vis-a-vis the nitazenes is the reason for their exclusion from this list. [doi.org/10.1016/j.jmcc… ; nature.com/articles/s4159…]
For more objective data on the nitazene class such as direct addiction drug preference studies in humans, I will refer you to the direct human addiction studies of the prototype, etonitazene, conducted by the aforementioned Harris Isbell in 1960 at the US Public Health hospital in Lexington, KY (aka: the "narcotic farm"). Etonitazene has been a staple of animal addiction studies since its discovery in 1957.
Without further adieu, I present the list of Oxycosmopolitan's Most Wanted
(1) Dextromoramide (R875) - approx 3 x more euphoric than heroin
(2) Dimethylmoramide (R860) - same
(3) Isomethadone (Win-1783)
(4) Ketobemidone
(5) Phenomorphone
(6) Oxymorphone (oxycodone is a prodrug; forming OM in vivo)
(7) Heroin
(8) Dipipanone
(9) (RS)-Beta-acetylmethadol (beta-isomer is formed by reduction of methadone in Na-Propanol)
(10) Morphine
(11) Levorphanol + Ro4-1539 (furethylnorlevorphanol)
(12) Desomorphine
(13) Acetylfentanyl
(14) Carfentanil
(15) Plain vanilla fentanyl
(16) Methadone
(17) Hydromorphone (Hydrocodone is a prodrug; forming the -morphone in vivo)
(18) Phenazocine
For more in-depth discussion into opioids, visit my Patreon at Patreon.com/Oxycosmopolitan


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@kevinvdahlgren Thats not even close to 99% pure. In order to have productive conversations on this topic we must be honest or at least not ignorant
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@BrianRoemmele Ever find sex tapes or snuff films on thrifted VHS?
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@jsrailton pretty much every canvaser ive ever met is working on similar terms and accepts cause usually are in hard times, often coming out of prison. these services are subbed out and these agencies are who to blame.
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WILD: actual photo of Musk-hired door knockers being driven around #Michigan.
This group of mostly-black workers were driven in the back of a truck with no seats.
They say they were flown in, given unrealistic goals, and threatened with their lodging being cut off & being forced to pay their own way home if they couldn't meet them.
Some didn't even know which candidate they were working for.
Article by @JakeLahut
wired.com/story/elon-mus…

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@DovePortland @KOINNews cascadia subduction zone dont work like that. here, it just increases strain
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EARTHQUAKE ALERT: A 6.0 magnitude earthquake occurred approximately 173 miles off the coast of Bandon at approximately 1:15 p.m. on Wednesday
trib.al/1Wq2RHD
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@Oregonian I dont understand why his cars are the most popular EV in Portland. Cars made by a literal magatt, enemy of democracy!
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Biden calls out Musk over a published report that the Tesla CEO once worked in the US illegally oregonlive.com/politics/2024/…
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@KOINNews But it was all set up - the McDonald's he used was closed to customers for the day so they could film him pretending to serve customers who were really staff who rehearsed beforehand.
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This comes after he spent weeks mocking Vice President Kamala Harris’s past experience at the fast-food chain. trib.al/2ln23Qc
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@larryjones @SpeakerPelosi i have to respect how she able to not only hold 7 drinks at altitude but also walk off WEARING HEELS. She prob even has a xanax Rx too. Fuckn tank she is.
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Dang @SpeakerPelosi you can really drink.
She talks loud to but hey at least we all know she is heading home to SF now.
Nancy why do you get so much security on a commercial flight and who is paying for it all?

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@ImNoclue @juliangillespie No I'm saying cells are specifically designed to defend against foreign dna
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Arkmedic does it again
.. it is not just the Pfizer and Moderna Covid shots that are contaminated with synthetic DNA, that gets into cells and the nucleus
try also - all the rest
arkmedic.info/p/would-you-li…

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