Mirko Paiardini

Learn how our Martin Delaney Collaboratory @EraseHiv is making a difference in #HIVresearch 🔬 #HIV #EraseHIV

Could dual immunotherapy be the key to overcoming HIV/SIV viral persistence? Our new research suggests it might be. Discover the details on @NatImmunol nature.com/articles/s4159… #HIV #HIVcure #HIVEremission #EraseHIV @EraseHiv

Happy to share the research briefing of our new paper that just came out on @NatImmunol nature.com/articles/s4159… #HIV #HIVcure @EraseHiv

Our paper describing a new CD8+ T cell population associated with control of SIV infection in lymphoid tissue of rhesus macaques is out on @NatImmunol Check it out ⬇️ #HIV #HIVcure @EraseHiv

10/ This study would not have been possible without the many contributions of our collaborators, the outstanding veterinarians at the ENPRC, and the support from our funding sources. Many thanks to all those involved with this study!

9/ We would like to dedicate this study in loving memory of our friend and colleague Tim Hoang. Tim made crucial contributions to HIV cure and SARS-CoV-2 research during his short but impactful career and is remembered for his drive, intelligence, and love of science.

1/ Excited to share our study published in @SciImmunology investigating modulation of type I interferon in SARS-CoV-2-infected rhesus macaques done in close collaboration with @BosingerLab and led by @elise_viox , @Timothy_N_Hoang , and @amitupadhyay85 science.org/doi/10.1126/sc…

8/ This study makes a strong case that while early IFN-I restrains SARS-CoV-2 replication, uncontrolled IFN-I signaling critically contributes to SARS-CoV-2 inflammation and pathogenesis in the moderate disease model of rhesus macaques.

7/ We also observed a reduction in pro-inflammatory immune cells in the BAL with IFNmod treatment as well as lower levels of lung pathology and inflammatory chemokines and cytokines.