Roselli lab Uni-Ulm

time to revisit excitation/inhibition balance in motoneuron disease: what have we actually learned? have a look: sciencedirect.com/science/articl…

What happens when brain people meet bone people? A study of bones in neurodegenerative disease: insight.jci.org/articles/view/…

what connects intracranial hypertension to neuroinflammation? in astrocytes the mechanosensor Piezo cross-activates EGFR, which in drives chemokine secretion and reduces water fluxes. from porcine model to human cells: latest preprintis out: biorxiv.org/content/10.110…

What happens to lipid metabolism in ALS? What connects hypothalamus to the movement of triglycerides across the body? Angiopoietins coordinate the repartitioning of lipids from muscles to brown adipose tissue when hypothalamus is neuro-inflamed : link.springer.com/article/10.118…

In the acute phase of traumatic brain injury, how does the body keep in check the inflammatory response? It appear that basophils are recruited to the spleen follicles to deliver much-needed IL-13 to dendritic cells : link.springer.com/article/10.118…

What happens if you remove inhibitory synapses from a motoneuron? does it die faster or slower? here our chemogenetic-nanobody in vivo study: jneurosci.org/content/early/…

What happens to hypothalamus in neurodegenerative diseases? It appears that its involvement is more common that previously thought. Our latest collaboration with the great group of Jan Kassubek: link.springer.com/article/10.100…

how can you avoid the brain-wide inflammation that occurs in a polytrauma patient? it looks like it depends on which structure of the brain you want to address. More in our latest preprint: biorxiv.org/content/10.648…

Can we identify new populations vulnerable to neurodegeneration in ALS using circuit tracing? We found an unexpected connection between motor cortex and hypothalamus: link.springer.com/article/10.118…

Are motoneurons directly sensitive to adrenergic neuromodulation? Yes they are! And they are through beta-receptors! But they are no fools, and can quickly adapt: sciencedirect.com/science/articl…

We have the honour to be in J Neurosci!

What happens to inhibitory synapses in ALS? how do they react to the changes in excitability and to the onset of the disease? We have used functionalized nanobodies and multiple chemogenetic systems with orthogonal pharmacology to explore them :jneurosci.org/content/early/…

ALS patients often experience a rapid weight loss, and changes in their serum lipids . We have elucidated one of the molecular mechanisms linking a set of angiopoietin proteins, with the neuroinflammation and atrophy of the hypothalamus: link.springer.com/article/10.118…

Invitations to students´symposia are among the highest acknowledgements one can receive: there is little politics involved, no money, no clubs... just interest in hearing about something new.

@lvolpic in my hands it hallucinate a lot of references. Grok usually gets the right, although it misses some key refs.

IMO Google Gemini is the best for biomedical research and finding papers and information related to scientific questions

our tracing approaches also support the concept of a circuit link between motor cortex and hypothalamic neurodegeneration in ALS.

We have used a rabies retrograde tracing approach to identify a new set of neurons vulnerable to degeneration in ALS: link.springer.com/article/10.118…

@ThePhDPlace definitely too little unless you are closely supervised by one or two senior postdocs (still too little, anyway).

How do you feel about this?

waiting for the outcome of 5 resubmitted-revised papers............

A new review article on synaptic abnormalities in ALS, led by Marco Milanese; we are glad to have been able to contribute: doi.org/10.1016/j.nbd.…