Steven Botts

Thank you @kat_howe and @FishLab_UHN !! It was an absolute pleasure completing this journey with your guidance and support. Very excited to share our research story in the days ahead!

Very excited about this study in @EmboMolMed, where we show that KRAS mutations drive glycolytic reprogramming of the endothelium in sporadic brain arteriovenous malformations. We show a synergistic impact of targeting glycolysis and MEK. link.springer.com/article/10.103…

Thanks @kat_howe and @FishLab_UHN !! Truly a team effort and ever grateful for the support of colleagues past and present.

An absolute blast participating and raising awareness during PAD month!! #stepwithSVS

1 week left for the 2025 Vascular Health Step Challenge! This Sept I am riding 1,500km to raise awareness for PAD prevention- 500 to go! 🚴 #stepwithSVS #pedalforPAD Come and join me in support of the Society for Vascular Surgery Foundation: charityfootprints.com/vascular/event…

September rides to raise awareness for vascular health! 🇨🇦🚴 @VascularSVS #stepwithSVS #pedalforPAD Come and join me at Vascular Health Step Challenge in support of Society for Vascular Surgery Foundation: charityfootprints.com/vascular/event…

Dr. @MattSmeds walks in the Vascular Health Step Challenge to raise awareness for PAD and the modifiable risk factors that can lesson pain for patients. He encourages you to do the same! 📲 Sign up & start walking today! ow.ly/WYqR50WNJ9Z #StepWithSVS #PADAwarenessMonth

@TL_Forbes @jmills1955 @VascularSVS Signed up for Sept! Great cause @kat_howe

Done ⁦@jmills1955⁩ ! Come and join me at Vascular Health Step Challenge in support of Society for Vascular Surgery Foundation: ⁦@VascularSVS⁩ charityfootprints.com/vascular/event…

Excited to announce my latest publication as the lead author, featuring the cover image! Impairment of stromal-epithelial regenerative cross-talk in Hirschsprung disease primes for the progression to enterocolitis | Science Translational Medicine science.org/doi/10.1126/sc…

Incredible work from Dr. Kathryn Howe and the @PMunkCardiacCtr team. Advancing our understanding of vascular biology is essential to improving care and preventing heart disease.

@NickLeeper78 Came for the dad joke and stayed for the masterclass in research dissemination!

Thanks for having me on the show. Fun to recount what we are working on in the lab, and am especially pleased to have been able to sneak in a dad joke at the end that I am sure will mortify my kids.

Our first grad spotlight: congrats @BaharBehrouzi !! Wishing you all the best in residency @McMasterGIM 😀

@MandyKZGuo et al found that endothelial cell communication can be tracked in #atherosclerosis. Endothelial-derived #EVs can be detected within #macrophages deep within plaques ahajrnls.org/43H7vSc @kat_howe @FishLab_UHN @CoreyScipione @SnehaRajuMD @SRBotts @sarv_PhD

I'm thrilled to share some new work from the @kat_howe lab! @MandyKZGuo and team developed a novel mouse model that allows us to track which cells interact with endothelial derived extracellular vesicles during atherosclerosis! More to come.. stay tuned! ahajournals.org/doi/10.1161/CI…

Congratulations to Dr. Clinton Robbins and the team at UHN’s @PMunkCardiacCtr on their new study published in @NatImmunol. Their work reveals how cigarette smoke can trigger deadly aortic aneurysms—and points the way to life-saving treatments. Read more: nature.com/articles/s4159…

@HaoYin20 @NU_JEANSS #EndMT until abstract portals remove character counts 🙏

@NU_JEANSS 😁ooooooo😁 Both are fine 😉

@HaoYin20 #EndoMT or #EndMT? We need a governing body on standardization of the nomenclatures omegaLUL

Next up is Dr. Jason Fish, who just presented his exciting discovery of ERG as a gatekeeper of endothelial homeostasis against atherogenesis! Lineage tracing + multi-omics unveiled major impacts on modulating EndoMT in atherosclerosis

Does the risk of stroke increase after radiation therapy among patients with head and neck cancer? @UofT student Kennedy Ayoo, a recipient of the Personnel Awards for Black Scholars, aims to find out! cihr-irsc.gc.ca/e/53749.html?h…

2025 Vascular Research Initiatives Conference (VRIC) vascular.org/vascular-speci… Attention all-this is THE meeting for vascular surgeon-scientists. Trainees encouraged to showcase your love for science and vascular surgery - a field rich for exploring better approaches!

Congratulations to Dr. Jason Fish for winning the 2024 Mid-Career Excellence Award in Blood and Blood Vessel Research! Dr. Fish’s background in gene regulation of blood vessels came together beautifully as he delivered his lecture entitled “Oncogenic signaling in the endothelium drives arteriovenous malformations” presented at the Canadian Lipid & Vascular Summit. Thank you to the Canadian Society of Atherosclerosis, Thrombosis and Vascular Biology for their continued partnership with the Institute of Circulatory and Respiratory Health of the Canadian Institutes of Health Research @CIHR_IRSC.