
Ye Yuan
55 posts

Ye Yuan
@YYReprod
Research Director at the Colorado Center for Reproductive Medicine (CCRM).






Systematic evaluation of retroviral LTRs as cis-regulatory elements in mouse embryos dlvr.it/T34SbT






🔔🔔ATTN ASRM SIG Members!! ➡️ Your meeting schedule is here:


(1/n)Very happy to share that our our new protocol for the large-scale production of Human Blastoids from naïve human embryonic stem cells is out in @CellStemCell! This work was a collaboration with @leo_jwu @CcrmResearch @deirdre_logsdon @YYReprod cell.com/cell-stem-cell…

(1/n) Our findings demonstrate that by promoting cell survival, shortening hypoblast differentiation, and inhibiting key pathways like TGF-β via ALK5, Hippo, FGF-driven RAS-RAF-MEK-ERK, and Src signaling has significantly enhanced 5iLA-blastoid formation efficiency.


📢Our paper on an IVM-modified media that enhances human gamete competence is now published. This work was a monumental effort, involving numerous individuals and processing many tissues during the COVID19 pandemic, but the outcome justified the efforts. Let’s dive into the paper


