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@Rainmaker1973 @grok is this true ?

Scientists just found a way to reverse osteoporosis – not just slow it. Researchers from the University of Leipzig and Shandong University have identified GPR133, a cell-surface receptor that functions as a master regulator of bone-building cells called osteoblasts. When GPR133 is switched on, osteoblasts ramp up activity and dramatically increase bone density. In mouse experiments, animals engineered without the GPR133 gene developed fragile, porous bones similar to human osteoporosis. However, treating them with a synthetic activator called AP503—a small molecule discovered through computational screening—rapidly strengthened their skeletons. Remarkably, AP503 not only boosted bone mass in healthy mice but also reversed osteoporosis-like damage in older or diseased animals, with even greater effects when paired with physical exercise. Because GPR133 influences bone density in humans and the underlying molecular pathways are highly conserved across mammals, the findings raise hope for a breakthrough osteoporosis therapy. Unlike existing drugs that merely slow bone loss (and often carry side effects or waning efficacy), a GPR133-activating compound could actively rebuild bone from within. This approach could be particularly transformative for postmenopausal women, who face the highest risk of debilitating fractures, offering a safer, more effective way to restore skeletal strength. ["The mechanosensitive adhesion G protein-coupled receptor 133 (GPR133/ADGRD1) enhances bone formation." Signal Transduction and Targeted Therapy, 30 June 2025]

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@enews 🥀💔

Carrie Anne Fleming, known for her work in "Supernatural" and "iZombie", has passed away at the age of 51. 💔bit.ly/3NKAGzQ

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@TMZ The goat is gone 🥀

🕊️ OnlyFans owner has died at 43. What we know: tmz.me/8RHa38d

@TMZ OG GOONER

@TMZ Crazy

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@centredevils @rtiesporte We are blinded yet once again

🚨🚨| NEW: Manchester United have held internal discussions about keeping Casemiro at the club beyond the end of the season. [@rtiesporte]

POV: Melihat selebrasi Bruno dari tribune penonton 🙌

@ManUtd_ID GGMU

they told me “declan” was supposed to win POTY 🤣🤣🤣

the face of a man who got a successful hatewatch

Bruno Fernandes is the only player to create 100+ chances in Europe’s top five leagues this season 😮 Another level 💫

Goals in major competition finals Me - 0 You - 0 Bukayo Saka - 0