Luis Graca

nature.com/articles/s4142… Happy to share our paper on Tfh specialization in antibody production on type-1 (virus) and type-2 immune responses (parasites, allergy). 1/11 #Tfhcells #germinalcentre #antibodies #immunology #bioinformatics. @kumar @imm @fmul @FilipaR @lgraca

We are very happy with this recognition for such an amazing topic! Luís Graça, @gimm researcher, has several collaborations with one of the three laureates, Shimon Sakaguchi. "Generous and humble", that's how Luís describes him.

Wise words from Gabriel Victora, a scientist whose vision and insights are a constant source of inspiration 💫 cell.com/news-do/50-ins…

Happy to present at #ACR24 our first data on scRNAseq and spatial transcriptomics in #Sjogrens. Minor salivary glands of early and late SjD revealed many different types of cell populations. More to come! Joint effort @lgraca lab @IMMolecular with #rheum & #path @ulssanta_maria

🤔🦠 Why is the flu vaccine less effective in older adults? A new study co-led by #CaixaResearch investigator @lgraca (@GIMM_Institute) sheds light on this question. Congratulations to the team on this work! 👏 medicalxpress.com/news/2024-09-c…

Happy to share the tweetorial of @saum_kmr, @YangLi_Lab on vaccine responsiveness in older adults. Timely as it is time to get the flu shot #VaccinesWork! I'm proud to be involved in the study! @GIMM_Institute @CaixaResearch

Glad to present our work on #flu #vaccine response in the elderly published in @ScienceAdvances. @Helmholtz_CiiM @YangLi_Lab. ciim-hannover.de/en/news/news/d…

First day at our new institute. Today, @GIMM_Institute officially started. I found this welcome note to remind me that while my office remains the same, exciting times are ahead! #science #discovery

@YUmmunology Thank you @YUmmunology !

Tfh heterogeneity. More pieces in the picture. Well done, @lgraca and the team.

This work was only possible with support from several organizations: @CaixaResearch @fct_pt @PesquisaFapesp among others.

Thanks to @ElianePiaggio @jimena75656604 @margarida_gamac - critical collaborators in this work, and @CyrilPedia for discussions.

Functionally, sorted Tfh1 and Tfh2 behaved differently in vitro (that was reassuring!). Cytokine production and even help to class switching was consistent with their in-vivo function. 6/11

We used #MachineLearning (#elasticNet #lasso) to find the minimal number of genes that could discriminate the two subsets. We validated the genes with samples from different labs and real infections (virus and parasites) 5/11

Are there Tfh1 and Tfh2 cells? In human blood, Tfh subsets resembling Tfh1 and Tfh2 were described, but not confirmed in lymphoid tissue, and Tfh1-like cells appear to be suppressive (Groundbreaking work from @ueno). We investigated this issue in mice. 3/11

First, we immunized mice with type-specific adjuvants to obtain TCR-transgenic Tfh cells from draining lymph nodes in two different strains of mice. Their transcriptome showed Tfh cells differ from Th cells, and type-1 from type-2. Promising! 4/11 #ComputationalBiology

Once upon a time, immunologists believed Th1 and Th2 cells interact with B cells in the germinal centre inducing isotype switching (to IgG2a in virus infections and IgG1 with allergy/parasites). Work of @carola @dong etc… showed that only Tfh cells interact with B cells. 2/11

nature.com/articles/s4142… Happy to share our paper on Tfh specialization in antibody production on type-1 (virus) and type-2 immune responses (parasites, allergy). 1/11 #Tfhcells #germinalcentre #antibodies #immunology #bioinformatics. @kumar @imm @fmul @FilipaR @lgraca