pylelab

📢ONLINE event this month! ⏲️5pm GMT, 14th Dec 2023, next Thursday! This month we happily invite Danny and Ling to show their exciting RNA structural stories! Please register our mail list for zoom link🥳 Many thanks to our sponsors @RNASociety @lexogen

“Incredibly dynamic” #RNA: Anna Marie Pyle’s group @pylelab sheds light on how a section of bacterial RNA catalyzes a reaction that frees it from its parent strand. This ancient splicing method still closely resembles that employed in human cells. 🔗 hhmi.news/3uCAuJb

Congratulations again to @Ling97520113, @ArthurLiuShuo and Kevin!

Also check out this movie that animates the full life cycle of the group II intron RNP (thanks to Margot and Janet again!).

Happy to share our new Nature paper looking at intron RNP structures through the stages of splicing!

Nature research paper: Structural insights into intron catalysis and dynamics during splicing go.nature.com/3QTKPYL

A recent paper from the Pyle Lab discusses the use of MRT-ModSeq for the detection of RNA modifications using 2D mutational profiles. Read more here: sciencedirect.com/science/articl…

Can #RNA recognize small compounds specifically? Can the #splicing core be targeted by #smallmolecules? Exciting answers in our new preprint on the molecular mechanism of splicing inhibition by intronistat b biorxiv.org/content/10.110… @EMBLGrenoble @IITalk @devivo_marco

Principles of #lncRNA structure-functional connections emerging! Our new work in press shows how lncRNAs use non-canonical #GUwobble motifs to shape their molecular structure and define their function doi.org/10.1016/j.bioc… @EMBLGrenoble @KariSabalette @epifiz87 @elsbiochimie

Congratulations to all the GRC 2023 Nucleic Acids poster award winners! The poster sessions were one of the highlights of the conference! If you’re thinking about applying for the 2025 GRC, we definitely encourage presenting a poster about your ongoing science! #grcnucleicacids

The GRS Nucleic Acids was also a great success! Thank you Mano and @KrishnanYamuna for spending time with the trainees and ECRs!

Special thanks to Xi Yang, NIH, for the group photo on the mountain! Please feel free to tag everyone in the photo in the comments section!

Dear Nucleic Acid GRC friends! Thank you all for attending the meeting, for all your energy, insights, and enthusiasm about our wonderful area of science.  We look forward to seeing you in 2025. #grcnucleicacids #grc23