David J [email protected]

Watch Magellan from @criterionchannl criterionchannel.com/magellan

Tell Congress to protect Medicaid home- and community-based services! via @MomsRising action.momsrising.org/sign/HCBS-2026…

Israel murdered every single person in this photo today in South Lebanon. Every. Single. One. 2 journalists 7 paramedics 1 Lebanese soldier They bombed the journalists’ vehicle — then bombed them again when paramedics rushed to help.

Se apaga el canto del guabairo. El proyecto Esencia en Cabo Rojo (residencias de lujo para millonarios extranjeros) amenaza el hábitat de una de nuestras especies nativas en peligro de extinción. Hoy son los bosques secos y toda nuestra costa, después el resto de la isla.

Columbia County Restaurants: Where to Eat From Hudson to the Hills chronogram.com/food-drink/din…

@oscar_puente_ 👏👏👏

@oscar_puente_ Ni con este 👇 tampoco:

@ghadaa231 Puerto Rico 🇵🇷

Good morning, we are still alive. If you stand with us, respond with your country's flag. 🍉🇵🇸

This is the type of treatment advance that gets me super excited. The treatments that are being optimized for other diseases are light years away from what is occurring in the MECFS or LongCovid research communities. I mean seriously, compare this to Putrino's recent announcement. I am not knocking brain based (in-clinic only) therapies, I think they could play an small adjunct role in comprehensive treatment - but the difference between treatments like mitochondrial transplants or Anktiva and what is being tested for MECFS specifically - they are just worlds apart.

🔴 @guillermofesser explica los problemas que se podrían encontrar millones de personas, especialmente mujeres, para votar en Estados Unidos si Trump consigue que pase la ley de votación que ha propuesto. #ObjetivoFacturaGuerra

Dysregulated NK-cell gene expression defines the enduring symptoms of long COVID-19 🚨Long COVID's crippling fatigue, lost smell & brain fog now traced to profoundly exhausted & depleted NK cells, maybe unlocking a precise immune target for real treatments at last. A further IMPORTANT confirmation! #LEONARDI_EFFECT ➡️This German study on long-term COVID-19 syndrome (LTCS, or long COVID) identifies immune dysregulation, centred on natural killer (NK) cells, as a driver of persistent symptoms like fatigue, pulmonary issues, and cognitive impairment in 2%–8% of SARS-CoV-2 survivors. ➡️IMPORTANT FINDINGS: 1. LC patients show sustained high anti-SARS-CoV-2 IgG titers (S1/RBD/N proteins) up to 500 days post-infection, similar to convalescents, but with markedly reduced systemic cytokines (e.g, IFN-γ, TNF-α, IL-6, IL-10, IL-8), signalling immune suppression rather than hyperinflammation, 2. Flow cytometry reveals depletion of CD56+ CD16+ NK cells and CD56+ CD3+ NKT cells in LTCS compared to healthy controls and convalescents, alongside altered T-cell activation states, 3. Single-cell RNA sequencing confirms NK cell loss and profound transcriptional changes (455 differentially expressed genes: 115 upregulated like PDCD4 and CXCR4, 340 downregulated like TGFBR3 and MBNL1), 4. Single-cell RNA-seq reveals NK-cell exhaustion and impaired neuronal/sensory pathways and links immune dysfunction to hallmark symptoms such as fatigue, loss of smell, and cognitive impairment, 5. Enriched NK pathways include circadian rhythm regulation and translational programs. 6. Suppressed ones involve olfactory perception, neurotransmitter/GABA signalling, and sensory smell, linking to neuroimmune dysfunction. 7. Functional validation shows impaired NK cell inflammation (reduced TNF-α), mirroring chronic viral exhaustion and contributing to symptoms via a neuroimmune axis, 8. Vaccination and reinfection are not discussed as factors influencing NK-cell dysregulation or long COVID persistence, 9. Some valid limitations mentioned. ‼️This groundbreaking study reveals that dysregulated, exhausted natural killer (NK) cells, with profound depletion, transcriptional rewiring, and impaired function, directly drive the debilitating, persistent symptoms of long COVID, linking immune exhaustion to neuro-sensory and fatigue pathways! ‼️So, according to this study, dysregulated NK cells fundamentally underpin long COVID's enduring pathology, calling for urgent NK-targeted interventions to avoid lifelong suffering for millions. #LongCOVID #NKcells #Immunology #AVOIDSARS2 frontiersin.org/journals/immun… FYI: @fitterhappierAJ

Connective tissue disorders are a common comorbidity in those suffering from: - Long COVID - ME/CFS - MCAS - POTS What might be the thread that connects these conditions together? We recently surveyed the medical literature to find answers and published our findings on Jeannie Di Bon's blog, Founder and CEO of The Zebra Club. Here is what we found: jeanniedibon.com/me-cfs-eds-lon…

@OdayMohamm65286 Take care!

I will not forgive anyone who sees this post and does not support me with a single word and ignores me. If you see this, leave even a dot chuffed.org/project/oday

@lady_valor_07 I…never had a boom box- though I have vague memories of a friend bringing one as amenity hanging out in Central Park…

6 for me!!….I feel confident nobody Has all 20!! How many for you?

We Must Demand Better for... #care2 thepetitionsite.com/tell-a-friend/…

@Hamzasharif5750 STRENGTH!

What A 250-Year-Old Winery Teaches Us About Adaption via @forbes forbes.com/sites/michelle…

@BasharInshasi .

If you’re scrolling, PLEASE leave a dot . it's just a dot . gofund.me/db117389