Cristina Lao-Peregrin

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Cristina Lao-Peregrin

Cristina Lao-Peregrin

@CrisMLP

Analyst on therapeutics (CNS).Neuronal plasticity. BDNF lover and amateur painter🎨 #biopharma #therapeutics

New York, NY Tham gia Ocak 2012
851 Đang theo dõi230 Người theo dõi
Cristina Lao-Peregrin
Cristina Lao-Peregrin@CrisMLP·
Start the year learning about TrkB and mGluR5 teaming up in the hippocampus, choreographing synaptic changes. BDNF and G-protein-dependent crosstalk lead the intricate dance of receptor crosstalk. Thanks to everyone that made it possible #trkb #gpcr doi.org/10.1016/j.celr…
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Cristina Lao-Peregrin
Cristina Lao-Peregrin@CrisMLP·
Given the co-expression of TrkB and mGluR5 in the nervous system and their roles in synaptic plasticity. The enhancement of TrkB-driven synaptic plasticity by mGluR5 positive allosteric modulators offers promising avenues for advanced antidepressant treatments.
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Cristina Lao-Peregrin
Cristina Lao-Peregrin@CrisMLP·
1. Our research describes a new RTK/GPCR crosstalk wherein mGluR5 amplifies TrkB effects to modify downstream signaling dynamics, leading to a unique form of BDNF-induced synaptic plasticity.
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Cristina Lao-Peregrin
Cristina Lao-Peregrin@CrisMLP·
I am happy to share a pre-print about my project at at Dr. Francis Lee's Lab on a novel form of synaptic plasticity. Please don’t be shy and share your feedback. All this work was possible to an amazing team, thanks to @JihyeKimMD and the rest of the team biorxiv.org/content/10.110…
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Cristina Lao-Peregrin
Cristina Lao-Peregrin@CrisMLP·
1. The identified crosstalk between TrkB and mGluR5 is facilitated through the cooperative action of Gbg, released from TrkB, and Gaq-GTP, released from mGluR5. This represents a novel and physiologically significant form of RTK/GPCR crosstalk.
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Cristina Lao-Peregrin
Cristina Lao-Peregrin@CrisMLP·
2. This interplay results in a distinct form of BDNF-induced synaptic plasticity characterized by sustained, oscillatory Ca2+ signaling and enhanced MAP kinase pathway activation.
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Cristina Lao-Peregrin
Cristina Lao-Peregrin@CrisMLP·
Proud to be part of this team 🥰
Francis Lee@DrFrancisLee

During #MHAM, I honor the countless hours of my lab team. We take a multidisciplinary approach to studying the function and dysfunction of neural circuitry with a particular focus applying this work to the progression & treatment of psychiatric disorders. Thank you!

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Francis Lee
Francis Lee@DrFrancisLee·
During #MHAM, I honor the countless hours of my lab team. We take a multidisciplinary approach to studying the function and dysfunction of neural circuitry with a particular focus applying this work to the progression & treatment of psychiatric disorders. Thank you!
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News from Science
News from Science@NewsfromScience·
A class of #Alzheimers drugs that aims to slow cognitive decline, including the antibody lecanemab that was granted accelerated approval in the United States in January, can cause brain shrinkage, researchers report. scim.ag/23J
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The Nobel Prize
The Nobel Prize@NobelPrize·
Happy International Women's Day! We're celebrating women who have changed the world. Here's all of the amazing women who have received the #NobelPrize and their remarkable achievements at the time of the award. Who are the women who inspire you the most? #IWD2023
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Matt Hill
Matt Hill@canna_brain·
Honored and excited to take on this Chair and advance our understanding of the relationship of physical and emotional trauma to mental health.
U Calgary@UCalgary

#UCalgary announces Dr. Matthew Hill as inaugural Chair of Mental Health Initiative for Stress and Trauma, exploring how the brain reacts to physical and emotional stressors ow.ly/SwrU50MsSxh @HotchkissBrain @UCalgaryMed @UofCr4kids

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HDBuzz
HDBuzz@HDBuzzFeed·
Wow - Roche has announced that in addition to a new trial of tominersen, it is working on TWO different approaches - a small molecule huntingtin splicing modulator (a bit like PTC518) and a mutant-only huntingtin-lowering ASO (like the Wave approach)
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Science Magazine
Science Magazine@ScienceMagazine·
Anthony Fauci has become one of the most recognizable physician-scientists in the world. For a new #ScienceEditorial, @hholdenthorp sat down with the outgoing #NIAID director to talk about the challenges facing science and his plans for the future. scim.ag/Qg
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GranadaOnline ®
GranadaOnline ®@GranadaOnline·
🔴 Irrespirable + peligroso el aire y humo ahora mismo en Granada 😷 #Incendio #Granada #Guajares
Ivan Ocete Garrido@ivanocete

@JuanMa_Moreno a qué espera para poner soluciones urgentes lo antes posible???? Hoy decreta el nivel 1 cuando el incendio está descontrolado desde hace días. Qué vergüenza de gestión, qué auténtica vergüenza.

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Science Magazine
Science Magazine@ScienceMagazine·
A new Science analysis of data from U.S. military recruits suggests multiple sclerosis—a disease considered of unknown etiology—is a complication of infection with Epstein-Barr virus. Learn more ⬇ fcld.ly/sicotxm #SciencePerspective: fcld.ly/ehqno7q
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Khám phá

@JihyeKimMD @DrFrancisLee @HotchkissBrain @UCalgaryMed @UofCr4kids @WCMResearch @hholdenthorp @RevNeurol