Matt Daugherty

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Matt Daugherty

Matt Daugherty

@Daugherty_Lab

Watching the constant battle between hosts and pathogens in the lab and in my kids.

San Diego, CA Tham gia Şubat 2018
215 Đang theo dõi980 Người theo dõi
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Harmit S. Malik
Harmit S. Malik@HarmitMalik·
I am delighted to share the latest preprint from our lab, which was work that was conceived and led by @JTenthorey during her postdoc and during the first few months of her independent lab at UCSF. biorxiv.org/content/10.110… TL;DR: Indels matter. A lot. 1/
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Matt Daugherty
Matt Daugherty@Daugherty_Lab·
Great work from @lizfay20 and a team of undergrads she has assembled! So much interesting data in this paper (check out the paper and Liz’s summary). Definitely the first of many great papers from Liz on host diversity in immune responses!
Liz Fay@lizfay20

Our latest preprint from @Daugherty_Lab is live on bioRxiv! We explore the evolution and function of RIP kinases across diverse vertebrates and identify differential conservation of RIPK1-5 and several key associated proteins. 1/ biorxiv.org/content/10.110…

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Matt Daugherty
Matt Daugherty@Daugherty_Lab·
Another great collaboration with @DengkeMa lab on the role of horizontal gene transfer (HGT) in providing novel functions to nematodes! Congrats to all, especially co-first authors Taruna Pandey and @ChinmayK98 !
The EMBO Journal@embojournal

Interdomain horizontal gene transfer: @dengkema, @Daugherty_Lab and coworkers find that key rml-3 gene conferring nematode exoskeleton resilience against environmental toxins appears to stem from the bacterial kingdom embopress.org/doi/full/10.15…

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Matt Daugherty
Matt Daugherty@Daugherty_Lab·
So great to reunite with all of these wonderful friends and scientists to celebrate such a fantastic mentor. Congratulations @HarmitMalik on all you've accomplished in the last 20 years!
Harmit S. Malik@HarmitMalik

A privilege to watch trainees thrive in science & life. Huge thanks to 70+ who traveled from as far away as France for 20 yr reunion hosted by Aida de la Cruz, @psmitchej & @Daugherty_Lab. My heart is full (& our bellies). I wish all mentors can feel what I'm feeling right now.

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Anthony Leung
Anthony Leung@LeungLab·
🎉 Congrats, Matt, Sofia, & Andy! Escaped notice all these years: the 1st macrodomain in PARP14 & PARP9 is a hydrolase removing ADP-ribose from protein! And here's a science curveball: The triple macrodomain arrangement in PARP14 echoes SARS-CoV-2's! Who would've thought?
Matt Daugherty@Daugherty_Lab

Very proud of Sofia Delgado-Rodriguez's first first-author paper (with a lot of help from Andy Ryan)! And it made the cover! This is part of a fantastic special issue on ADP-ribosylation organized by @LeungLab and @FehrLab.

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Matt Daugherty
Matt Daugherty@Daugherty_Lab·
Very proud of Sofia Delgado-Rodriguez's first first-author paper (with a lot of help from Andy Ryan)! And it made the cover! This is part of a fantastic special issue on ADP-ribosylation organized by @LeungLab and @FehrLab.
Pathogens MDPI@Pathogens_MDPI

🎉 #PathogensMDPI, Vol. 12, Issue 5 🔖 Cover Story: Recurrent Loss of #Macrodomain Activity in Host #Immunity and #Viral Proteins by Sofia E. Delgado-Rodriguez, Andrew P. Ryan, and Matthew D. Daugherty @Daugherty_Lab @UCSanDiego 👉 mdpi.com/2076-0817/12/5 #ADPribosylation

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Matt Daugherty
Matt Daugherty@Daugherty_Lab·
This suggests that changes in enzymatic activity in host and viral macrodomains might be part of the ongoing host-virus arms race over ADP-ribosylation. More details in the paper. Exciting times to study ADP-ribosylation in the immune response and viral replication!
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Matt Daugherty
Matt Daugherty@Daugherty_Lab·
But many macrodomains hadn’t been tested for enzymatic activity. Not surprisingly, many host and viral macrodomains are enzymatically active. What was surprising was that enzymatic activity has been lost several independent times in mammals as well as in alphaviruses.
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Dustin R. Glasner, PhD 남궁수🇰🇷
Dustin R. Glasner, PhD 남궁수🇰🇷@drglasner·
Also, check out my episode of “Let’s Meet the Virologists” to learn a little about me and my career. Thanks to @lbthackray for having me on!
American Society for Virology@AmerSocVirol

Meet Dustin Glasner @drglasner who studies the interface between #viruses and #innate_immunity. Check out his #ASV2023 Talk W8-1: Recognition of non-self viral mRNAs by the IFIT2 and IFIT3 heterodimer #LoveVirology lmtv.podbean.com/e/lmtv-episdoe…

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Dustin R. Glasner, PhD 남궁수🇰🇷
Dustin R. Glasner, PhD 남궁수🇰🇷@drglasner·
With #ASV2023 only a few days away, this seems like a good time to resurface here on Twitter. Come hear all about my research with ⁦@Daugherty_Lab⁩ on Saturday in the Innate Immune workshop. Can’t wait to connect with my fellow virologists for the first time since 2016!
Dustin R. Glasner, PhD 남궁수🇰🇷 tweet media
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Matt Daugherty
Matt Daugherty@Daugherty_Lab·
Very proud of @underthelenns for her first first-author manuscript! She wrote a fantastic review on the evolution and mechanisms of 'tripwire' sensing of viral infection by the CARD8 and NLRP1 inflammasomes. Many more great things to come from Lennice!
Lennice Castro@underthelenns

Excited to see that our review on tripwire effector-triggered immune sensing of viral proteases by CARD8 & NLRP1 is out! My first, first-author pub, and I was lucky to write it with @Daugherty_Lab and the support of fellow Daugherty Lab members. sciencedirect.com/science/articl…

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Matt Daugherty
Matt Daugherty@Daugherty_Lab·
Our paper on CARD8-mediated sensing of infection by SARS-CoV-2 (and other coronaviruses and picornaviruses) is now out in @PLOSBiology ! journals.plos.org/plosbiology/ar……Huge congratulations to all involved! More info and thanks to our many collaborators are in the thread below:
Matt Daugherty@Daugherty_Lab

New preprint out showing a cool new host- and virus-specific way that the immune system has evolved to sense coronavirus infection! biorxiv.org/content/10.110… Congrats to everyone involved, especially force-of-nature first author @BriBerryTea! 1/

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Khám phá

@JTenthorey @lizfay20 @DengkeMa @ChinmayK98 @ASAP_Research @aleschziner @HarmitMalik @LeungLab