Denholm Lab

Our paper on the evolution of Cryptonephridial/rectal complexes in scarab beetles is just out in Arthropod Structure & Development sciencedirect.com/science/articl…

PhD position in @DenholmLab ' Exploring form & function in one of nature’s most powerful water-conservation systems' working on insect renal system development, physiology and evolution. findaphd.com/phds/project/e… apply by 17th January 2025. Please repost

journals.biologists.com/dev/article/15… Excited to have this published in Development - the first molecular insights into development / cell type specification in the beetle cryptonephridial complex

The latest on the beetle cryptonephridial complex from our collaboration between @DenholmLab and @HalbergLab doi.org/10.1101/2024.0…

Here is our first foray into the digestive/renal systems of scarab beetles biorxiv.org/content/10.110…

How do some insects survive without access to water? By drinking from the air with their anus of course! Also, new online resource for #Tribolium enthusiasts, BeetleAtlas.org. New preprint from the lab: biorxiv.org/content/10.110…. Great colab with @DenholmLab+many not on T

New Research: Piezo buffers mechanical stress via modulation of intracellular Ca2+ handling in the Drosophila heart frontiersin.org/articles/10.33… #Physiology

Our paper is out! - How does proximo-distal patterning occur in the epithelial Malpighian/renal tubules? Cells are patterned early by a mechanism involving Wingless/Wnt, and expand by cell proliferation to generate a distal domain frontiersin.org/articles/10.33…

@JohnCam_Brennan Hi John, Are you related to Julian? Trying to get in contact to publish work he did in my lab. Can you ask him to mail Barry in Edinburgh. many thanks!

Paradise lost. 7 years ago! Collecting mulberry leaves with @AdiSaxena4 to feed our Bombyx caterpillars. Milton's mulberry tree #ChristCollege #Cambridge #paradiselost

Belly dancer. Movie of a fly crop imaged by @EdinburghUni undergrads having fun in the lab #drosophila #drosophilagut #gut #fridayafternoonexperiments

PhD position - Emergence of functional polarity in a tubular epithelium thenode.biologists.com/phd-position-e… via @the_Node

anyone interested in a PhD in tubes? findaphd.com/phds/project/e…

5th Scottish Fly Meeting: Friday 6th December 2019 at Edinburgh University. Please join us, it's free: eventbrite.co.uk/e/5th-scottish…

Fly people - 5th Scottish Fly Meeting will be on Friday 6th December 2019 in Edinburgh! Please save the date and spread the word. More details to follow

Fab new manuscript on rodent limbs from @AdiSaxena4 and @UCSDCooperLab Interspecies transcriptome analyses identify genes that control the development and evolution of limb skeletal proportion biorxiv.org/content/10.110…

Excited to share our publication on Wg gradient signaling in Drosophila wing discs. Online now @Dev_journal dev.biologists.org/content/146/15… Also check out the research highlight. Thanks and congratulations to all collaborators. Very proud of Swapnil's work.

Check out their full Open Access paper 'Robust Wnt signaling is maintained by a Wg protein gradient and Fz2 receptor activity in the developing Drosophila wing' here: dev.biologists.org/content/146/15…

Here we go. Gradient-independent Wnt signaling instructs asymmetric neurite pruning in C. elegans biorxiv.org/content/10.110…

Today, I have got a review report from @PLOSONE after a more than 3 months of waiting ... reviewer #3 wrote: "Overall my assessment is very negative and I would discourage the publication of this work (even after substantial revisions) in any scientific journal" 🤣 #NeverGiveUp