Jay Gertz

Glad to share our latest work on The EstroGene2.0 database for endocrine therapy response and resistance in breast cancer models, now published in @Nature_NPJ #npjBCancer, shorturl.at/WPiJK, with the super-multifunctional browser estrogeneii.web.app

We thank NCI for supporting our work in 3D cancer genomics! This work was led by our grad student Katie Mortenson, co-supervised by K-T Varley, with close collaborations from Yang Liu, @GertzLab , and @Sven_Bailey.

@biorxivpreprint @tweeterginley @CraigRushPhD @xyzxiaoyang We also found that promoters of estrogen up-regulated genes loop together. CRISPRi of a set of 3 promoters uncovered cooperativity between the promoters. Overall, chromatin loop analysis uncovered interesting patterns; but it is not the full story of ER-based gene regulation

@biorxivpreprint @tweeterginley @CraigRushPhD @xyzxiaoyang We thought that ER bound sites with differential loops would be more important than other ER bound sites. But after using CRISPRi to target 24 regions, the effect was subtle and not significant. Therefore, looping changes are not required for an ER bound site to be functional 3/

Estrogen-induced chromatin looping changes identify a subset of functional regulatory elements biorxiv.org/cgi/content/sh… #bioRxiv

Our latest Review is live! Thanks to ⁦@GertzLab⁩ and ⁦@RMJesel⁩ for your help and ⁦⁦@EndoSocJournals for publishing⁩! track.smtpsendmail.com/9032119/c?p=1c…

This excellent review on estrogen receptor alpha mutations, truncations, heterodimers, and therapies, goes into the history of ERα, current research unlocking unknown aspects of ERα signaling, and future directions of ESR1 investigation @RMJesel @GertzLab pubmed.ncbi.nlm.nih.gov/38643482/

Our work on how enhancers impact estrogen transcription timing and noise is now out in @CellGenomics! Thanks to everyone that helped out on this project! cell.com/cell-genomics/… @tweeterginley @xyzxiaoyang

Our latest review article on estrogen receptor targeted therapies in breast cancer has been published! academic.oup.com/endo/advance-a…

We are recruiting! Time to recirculate this work since there’s still so much to do. If you have expertise in DNA damage repair #DDR and are looking for a postdoctoral position where you can lead clinically-relevant discoveries, please don’t hesitate to reach out. @KUMedCenter

@gdstormo @generegulation Congratulations!! Thanks for being a great role model and thesis committee member!

Today is my last day as a Professor. Tomorrow I become Professor Emeritus. The 50+ years I've been in the field has seen revolutionary advances in both biology and computer science and it has been a joy to in the midst of that.

@aaronquinlan Nice! Although I prefer later vintage WS champion Wade Boggs on horseback

Wade Boggs, 1986. KFC bucket and case of beer not pictured.

@NeliMUlrich @AlanaWelm @huntsmancancer @BryanWelm @HolmenSheri Thanks Neli!

This week is National #PostdocAppreciationWeek. Zannel Blanchard, PhD (@xedbee) is a postdoctoral fellow in the Welm lab. She explains the role of a postdoc, what inspired her to become a cancer researcher, and why she loves working here. #HCIproud

@aaronquinlan @goosetheband Yeah, it was a great show!

Killer show from @goosetheband last night in SLC.

Want to work in the heart of Dublin where cutting-edge research meets a super friendly lab environment? 🍀 Dive into the world of breast cancer brain metastasis with us. Dublin’s warmth and our team’s camaraderie await you! Apply now: euraxess.ec.europa.eu/jobs/138568

Endometrial cancer is the most common gynecological cancer and high levels of estrogen promote its development. Researchers at HCI, led by @xedbee and @GertzLab, have identified potential new treatment options for people with endometrial cancer. bit.ly/47GqKwn

@ramgar29b @NeliMUlrich @VarleyLab Great to see you and great photos!

My pleasure to have officiated the Gordon Conference Hormone Dependent Cancers 2023 Breast Vs Prostate Football Match. The breast team emerged happy & victorious 4-2 🏆🍾 @MagnaniLab_ICR @oesterreichs @DanielFrigo @damirvareslija @dralexswarbrick @drmcrl @BevanLab @scottdehm