vittorio

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vittorio

vittorio

@IterIntellectus

practice expert “unique online personality” former TPOT thinker (exiled) professional shitpoaster @SpaceX don't take me seriously

Mars Tham gia Mayıs 2023
2.1K Đang theo dõi177.6K Người theo dõi
Jonathan Chang
Jonathan Chang@ChangJonathanC·
claude code is asking permission to edit file when bypass permissions is on @bcherny
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vittorio
vittorio@IterIntellectus·
the mushrooms want you to live longer but they dont want you to reproduce. parasitic alien species confirmed
Bryan Johnson@bryan_johnson

Two doses of magic mushrooms degraded my sperm count from the 99.6th percentile to the 77.7th. This may be a first-in-human observation. Context: we ran the most quantified magic mushroom (psilocybin) experiment ever conducted. We were asking if psilocybin is a longevity therapy. After seeing the data, we think it is (see reply post for the experiment summary). Also, like most things biology: the results are complicated. My data suggests that the magic mushrooms (psilocybin) negatively impacted my fertility markers. Before the first psilocybin dose my motile sperm count was at 99.6th percentile for men under 25 years of age, it dropped to 77.7% and partially recovered to 89.3% following the first dose, and second doses, compared to the same age cohort (numbers compare similarly to my age cohort as well). 3 days following my second dose (first dose 25 mg, second dose 28 mg) . Motility: dropped 51% . Total count: almost unchanged, dropped by 2% . Total motile count: dropped 52% . Normal morphology: dropped by 50% 20 days post 2nd dose, the pattern continued, with typical latent effects on total sperm counts Motility: recovered back to -2% of pre-psilocybin baseline: . Total count: dropped by 38%, latent effect. . Total motile count: remained inhibited at -39% of pre-psilocybin baseline, (despite motility normalizing, due to the total count drop) . Morphology normalized to -10% of baseline levels. Reduction in free testosterone might have contributed to the effect. While total serum testosterone increased by 30% 3 days following the 2nd dose (neither FSH or LH were meaningfully affected either), and continued to be at 11% above baseline, SHBG increased by 37%, SHBG binds testosterone and reduces its bioavailability and activity. My free testosterone (direct) showed 24% and 23% drops at 3 and 20 days post 2nd dose. In light of the neuroplastic, well-being, brain reset, and systemic metabolic and anti-inflammatory benefits, the trade-off is probably worth it. Especially considering that the magnitude of inhibition has no meaningful effect on actual fertility (total motile counts above 50 million are still on the safe side). This is a first-in-human observation, to our knowledge there is no published human clinical study demonstrating that psilocybin diminishes male fertility markers. General mechanistic evidence exists for recreational and psychoactive drugs possibly inhibiting fertility markers due to their effects on the hypothalamus-pituitary-adrenal axis and general hormonal reset.  Yet no direct evidence for psilocybin or other similar psychedelics inhibiting fertility markers exist. A potential mechanism for the immediate inhibition of motility could involve direct serotonergic signaling in sperm. Human sperm express multiple serotonin receptors, including 5-HT2A, and one recent study found that a 5-HT2A antagonist reduced sperm motility, suggesting that 5-HT2A may regulate motility. Psilocybin is known to bind 5-HT2A with high affinity.

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vittorio
vittorio@IterIntellectus·
i just found out that "BPC" in BPC-157 stands for "Big Pp Cocktail"
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vittorio
vittorio@IterIntellectus·
every year the UN revises the projections downward and every year the actual numbers come in worse than the revision 200 million fewer people than expected and the expectation was already catastrophic at some point this becomes a countdown
DogeDesigner@cb_doge

Global population to shrink this century as birth rate falls. The world is set to have 200 mn fewer people than previously expected by 2100. Fertility rates have fallen below the replacement rate in most continents.

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vittorio
vittorio@IterIntellectus·
if the longevity vs fertility tradeoff makes sense for bryan, great for him he's starting from the 99.6th percentile and has room to fall but the average man does not a 50% decline in motility after two doses is a reproductive catastrophe for someone already at the median don't do drugs if you want a future beyond yourself
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vittorio
vittorio@IterIntellectus·
the timeline is the part that's insane police reports filed in the early 2000s, social workers flagged it, councils were briefed, CPS knew. the institutional response was to classify it as a community relations problem and arrest the people who talked about it twenty years thousands of girls raped and zero accountability for the people who chose to look away
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vittorio
vittorio@IterIntellectus·
my conspiracy theory officially, less than 1% of women wanted this. it passed after 46 minutes of commons debate, without public consultation or evidence sessions, it was tagged onto a crime and policing bill while being the biggest change to abortion law since 1967 this is the same country that spent a decade covering up industrial scale raping gangs because they were afraid of "community relations" women getting pregnant from rapes nobody would prosecute, unable to legally terminate, ending up in courts that force questions nobody in government wants to answer so what do you do. you can't face the gangs issue because that means facing the corruption and the coverups. you can't arrest the girls because that leads back to the gangs again. so you make the abortions legal and stop talking about the rapes
Dr Rahmeh Aladwan@doctor_rahmeh

The UK House of Lords has just legalised abortion up to birth. Women can now end the life of their unborn baby at any stage, for any reason, without legal consequences. A truly dark day for Britain.

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techniacus
techniacus@Techniacus·
Good morning, let's finish strong
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yosoymario
yosoymario@yosoymario91·
Arm day
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vittorio
vittorio@IterIntellectus·
this is art
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