Jiang Lab

We are the Jiang Lab located @UTHealthSA! We are a multidisciplinary lab group interested in basic and translational science relating to how #connexin #channels affect a multitude of cellular processes. #Follow for research and lab updates 😀 #biochemistry #Science #sanantoniotx

Super happy to share recent work from our team at @Biomol_MDPI “Proteoglycan Dynamics and Bone Quality: Molecular Regulation to Age- Related Fragility” @JeanJiang17 @Huatouer @UTHealthSA @TheLongSOM @UTSOMResearch mdpi.com/2218-273X/16/4…

Congratulations to our outstanding mentor, Dr. Jiang, for receiving the prestigious award from #ASBMR! Your dedication and contributions to the field are truly inspiring. Well-deserved recognition! 🎉🏆

🎉Excited to share our latest publication in Redox Biology. We uncover a novel mechanism linking Cx43 HCs mechanosensing to GSH transport, crucial for maintaining redox balance in lens. #cx43 #connexin #redoxbiology #jeanjianglab Check the link 👇 sciencedirect.com/science/articl…

Principal Investigator Jean X. Jiang (@JeanJiangLab) pioneered the modulation of hemichannel activation using targeting antibodies. Her team at @UTHealthSA discovered two targeting antibodies: one to open the hemichannels and another to block. While other teams have been able to block hemichannels, Dr. Jiang’s team was the first to activate and open the hemichannel. “The Welch Foundation grant helps us tremendously because Welch is willing to invest in projects that could be high risk but also have the potential for very high impact, projects that would not be funded by traditional grants. One of the ways we mediate this risk is by switching approaches. Welch is terrific because they allow us to have this kind of flexibility.” Read more about Dr. Jiang and her team’s work here: buff.ly/3QxjWtM

@Mwan4Mei @PNASNews @JingruoZz @JeanJiang17 @LingQin6 @FrancyMAcosta @Huatouer @WangxUT12 @LidanZhang1995 Thank you!

@JeanJiangLab @PNASNews @JingruoZz @JeanJiang17 @LingQin6 @FrancyMAcosta @Huatouer @WangxUT12 @LidanZhang1995 Congratulations

🚨New paper alert in @PNASNews @JingruoZz reveals how osteocyte regulate MSC fate through connexin hemichannels & PGE2 signaling! 🔬Osteocyte connexin hemichannels and prostaglandin E2 release dictate bone marrow mesenchymal stromal cell commitment | PNAS pnas.org/doi/10.1073/pn…

Exciting research from our lab! 📢 Our latest study explores the critical roles of biglycan and decorin in bone mass regulation, water retention, etc. Check it out! #BoneResearch The full text of the paper through the link: nature.com/articles/s4141…

Thank you for the invitation! I really enjoyed meeting everyone and learning about the great science @UTHealthSA

It was a privilege welcoming Dr. @DrSilviaPenuela to @UTHealthSA this week!! Thank you Dr. Penuela for your incredible talk and insights 😁!!! @UTHSAResearch @igjc2024 #connexins #pannexins #channels

#ASBMR2024 ASBMR is more than just cutting-edge research and innovative applications; it's a hub for brilliant minds and cherished connections.@ASBMR @JeanJiangLab

#ASBMR #ASBMR2024 Thanks to everyone who stopped by our plenary poster yesterday! We had the opportunity to engage with many incredible researchers. If you missed it, don’t worry! We will be presenting again today from 2:15–3:45 pm at Poster 505. We hope to see you there!

Wooooo CONGRATULATIONS 🍾🎉 to our incredible Dr. @Huatouer !!!!!! Sooooooo proud 🥹. @igjc2024 😁

Congratulations to the #IGJC2024 poster winners! PhD students: 1st: Paras Gupta (Sorgen Lab) 2nd: Xinyue Ding (Korkhov Lab) 3rd: Justin Tang (Penuela Lab) Postdocs : 1st: Chelsea Philips (Smyth Lab) 2nd: Rui Hua (Jiang Lab) 3rd: Md Ruhul Amin (Gourdie Lab)

Great talk Dr Bruce J Nicholson, thanks for sharing! "Gap Junctions - a window into the origins of endometriosis and a pathway to diagnosis and therapy."

@JeanJiangLab is super excited to be here at @igjc2024 #igjc2024!!! @FrancyMAcosta @Huatouer @JeanJiang17 @UTHealthSA @UTHealthSA_GSBS @UTSOMResearch

Great job Dr Francisca Acosta, thanks for sharing all of your very interesting data! "Connexin Hemichannel Opening in Osteocytes and PGE2 Release: A Mechanism for Reducing Adiposity, Enhancing Metabolic Balance, and Maintaining Lean Mass"

Congrats @WangxUT12 for the GSBS Weekly Newsletter @JeanJiang17 @UTHealthSA_GSBS. The detail link is below: cell.com/cell-reports/f…

Good news from our lens group. A new published paper”Mechano-activated Connexin Hemichannels and Glutathione Transport Protect Lens Fiber Cells Against Oxidative Insults” in #RedoxBiology. Welcome to get some details for how Cx HCs regulate #oxidative #stress.

@CellReports Excited to be able to share this with the world 🌎! #connexins #ATP #Osteocytes #CancerResearch @UTHSAResearch @UTHealthSA_GSBS @FrancyMAcosta @WangxUT12 @UTHealthSAMDA @UTSOMResearch @TheLongSOM

Antibody-activation of connexin hemichannels in bone osteocytes with ATP release suppresses breast cancer and osteosarcoma malignancy dlvr.it/T8R7D3

Thrilled to share our another new publication “Connexin Hemichannels Drive Lactation-induced Osteocyte Acidification and Perilacunar-Canalicular Remodeling” in #CellReports! Please check out the paper regarding how Cx HCs remodel bone matrix during lactation.#bone #lactation🎉