Salic Lab

Our structure of thee BBSome is out: cell.com/structure/full…. We find evidence of a conformational change upon recruitment to membranes. Fantastic collaboration with Tom Walz, special thanks to Hui-TIng Chou who kept working on this project for 6+ years.

We are at a loss of words. May she rest in peace. Our thoughts are with her family, friends and colleagues. Let us remember SUZANNE as the phenomenal thinker, mother and human being she was... mpi-cbg.de/news-events/la…

With a heavy heart we have to inform you that SUZANNE is missing from her hotel @orth_acad_crete since Tuesday. She was attending a meeting in Kolymbari, Crete. Search is on in full swing. Please spread this to reliable networks and PRAY for her safe return.(1/2)

We’re thrilled to share the #CryoEM structure of the Cdc48-UN complex bound to and unfolding a polyubiquitinated substrate! Cdc48 first unfolds a K48-linked ubiquitin moiety allowing the processing of diverse substrates. Congrats to Zhejian and @cryoET! science.sciencemag.org/content/early/…

A review from our own Jenn Kong on biochemical mechanisms of Hedgehog signaling, written with Christian Siebold, is out in Development-- includes an analysis of the many patched and smoothened structures. @Dev_journal dev.biologists.org/content/146/10…

A big congratulation to Prof Stephen Harrison who will receive Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research "for his fundamental and far-reaching studies of protein structure using X-ray crystallography" tonight during an award ceremony at @BrandeisU

Team Steptonemes taking on the Take the Stairs challenge @HarvardChanSPH. @kornberg_t look closely!