Steensma Lab

Congratulations to our newest graduate, Dr. Rae House! 🎓All the best for your postdoctoral research with the Lien Lab @eclien

To learn more about the role of Nf1 in pretumorigenic mammary stromal cells, check out our newest publication in @FrontCellDevBio 🐁 frontiersin.org/articles/10.33… Congrats to first author @amenusha , @VAInstitute cores, & collaborators that contributed to this study 💐 #EndNF

Registration closes May 10 for the VAI Epigenomics Workshop. This 3-day, hands-on, problem-based experience will immerse PhD students in the latest epigenomics research and techniques. Please share with anyone who might be interested! vai.org/event/vai-epig…

A new doctor in the house 🎉 Congratulations to Dr. House for successfully defending her dissertation today🥂

Congratulations to first author @jamie_grit , @sydney51605 + other coauthors, and collaborators! 💐 #EndNF

p53 loss drives a selective clonal advantage in MPNST by promoting acquired resistance to targeted kinase inhibition and modulating lineage plasticity pathways.

Excited to share our newest publication in @oncogenejournal 🎉 “p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs” Highlights below 🧵 Read full paper here: nature.com/articles/s4138…

@SteensmaLab authors.elsevier.com/a/1ijZa,WJlgRIR Read the full article for free here!

Congratulations to first author @jamie_grit and coauthors! 🎉 Read more here: pubmed.ncbi.nlm.nih.gov/38395106/

As proof of principle, we employed our novel explant model to extend our prior findings regarding differences between downstream RAS-mediated inflammation in CNFs. We found that ex vivo glucocorticoid treatment was able reduced inflammation in these explants.

In our latest publication in @theJIDJournal, we developed a patient-derived explant model for cutaneous neurofibromas that can be leveraged for mechanistic studies and preclinical drug testing.

Congratulations to graduate student, Rae House, on her first first author publication! 🎉 Thank you to our funding sources, coauthors, collaborators, and @VAInstitute cores for all their contributions to this project.

Highlights: - NF1 deficiency -> metabolic reprogramming in ER+ BC - NF1-driven metabolic reprogramming = OXPHOS constraints, glutamine TCA influx, & lipid pool expansion - NF1-deficient ER+ BC cells have increased sensitivity to combined RAS + triglyceride synthesis inhibitors

Excited to share a new publication from our lab - NF1 deficiency drives metabolic reprogramming in ER+ breast cancer. Read more here; sciencedirect.com/science/articl… Highlights below 🧵

Welcoming our newest cohort! Welcome to our 12 newest students in our PhD program! #PhDinMolecularandCellularBiology @VAInstitute #biomedicalsciences #futurebiomedicalleaders 🧬🧫🔬🧪

How we feel about getting the official Notice of Award for @pat_dischi’s successful F99/K00 🎉 congratulations Patrick!

Congratulations to our two new graduates - Dr Lauren McGee and Dr Menusha Arumugam! 🎓🎓 Both are moving on to postdoc positions; Lauren @sydney51605 with the LeBlanc Lab at NIH and Menusha @amenusha with the @Hilgendorf_Lab at U of Utah. We will always be rooting for you 💙

All the love and support I had through the past 6 years was condensed into such a special graduation day! Officially a @SteensmaLab and @VAInstitute Graduate School alumni! 💙🤍 Excited to move out west this summer and start the next stage of my journey with the @Hilgendorf_Lab

Having a great time talking science and meeting cool people at the Mammary Gland GRC! @Mammary_journal @GordonConf #MGBGRC2023