ChenLabToledo

🔬 Cell-type-specific GCaMP6 miniscope imaging of a freely-behaving mouse brain. ~1,200 excitatory CA1 hippocampal neurons were imaged during active behavior over months. Courtesy of the Schnitzer Lab, Stanford. #MicroscopyMonday #Neuroscience #Lifescience

@foodskop @UWMadison @uwgenetics @UW_LSC @uwmadisonarts Congratulations!

Absolutely honored to win this prestigious science outreach award Excellence in outreach recognized with 2026 Bassam Z. Shakhashiri Public Science Engagement Award ⁦@UWMadison⁩ ⁦@uwgenetics⁩ ⁦@UW_LSC⁩ ⁦@uwmadisonarts⁩ research.wisc.edu/uncategorized/…

In the latest issue! Calcium signaling in plants: Universal and unique paradigms dlvr.it/TR7bm8

Protocol to identify mechanosensitive nuclear proteins using tunable actomyosin contractility and proximity biotinylation in mammalian cells @StarProtocols #bps2026 hubs.ly/Q04482qB0

Step-by-step protocol and reproducibility Generate iPSC-derived 3D neurospheres for neuron–glia studies. Date: March 25 | Time: 12:00 pm ET Free Register: ascb.org/ascb-meetings/…

Cell Bio 2026 is built by scientists, for scientists—and it starts with your ideas. Submit a scientific session proposal and help shape the program. 🗓 Deadline: February 22, 2026 Submit Now: ascb.org/cellbio2026/

.@richa_rikhy lab @IISERPune show Drosophila Missing-in-Metastasis (DMIM) (also called MTSS1) promotes Rac1 mediated branched actin network formation & endocytosis to drive rapid, cyclical plasma membrane remodeling during embryonic syncytial divisions hubs.la/Q040wrqn0

AlphaGenome is out in @nature today along with model weights! 🧬 📄 Paper: nature.com/articles/s4158… 💻 Weights: github.com/google-deepmin… Getting here wasn’t a straight path. We sat down @googledeepmind to discuss the story behind the model, paper & API: youtu.be/V8lhUqKqzUc

Cell biology for a sustainable future – a call to action from Camila Costa, Eliott Flaum, Delfina Hlashwayo @DHlashwayo, Marie Jacobovitz, Guillermina Kubaczka, Samuel Lovat, Eliya Milshtein, Hanna Szafranska @HannaSzafransk1 and Soraya Zwahlen. journals.biologists.com/jcs/article/13…

Review: Siqi Deng, Zhiqiang Yan et al. @hkust summarize the physiological functions and structural basis of OSCA/TMEM63 proteins, positioning them within a mechanosensitive ion channel superfamily. hubs.la/Q03ZL0yH0 #Physiology #Neuroscience #Mechanobiology #IonChannels

New research from Lee, Higgs et al. @GeiselMed shows how #INF2, a key #actin regulator, is activated by calcium-calmodulin and free actin monomers. Actin-binding proteins like profilin and thymosin aren't just helpers - they directly tune INF2 activity. hubs.la/Q03ZT5_k0

This study presents new tools for measuring the intracellular calcium concentration close to transmitter release sites, which may be relevant for synaptic vesicle fusion and replenishment. elifesciences.org/reviewed-prepr…

@NIH has launched the nation’s first dedicated Organoid Development Center to accelerate human-based research and to complement animal models. The center will support new 3D tissue models to study disease, drug response, and human biology. bit.ly/4pBYT9T

Spotlight: Ivan Radin discusses new work from Ryken et al. (hubs.la/Q03YtQV90) which shows how localization and function of autoinhibitory calcium ATPases maintains the strength of the tip-focus Ca2²⁺ gradient during polarized plant growth. hubs.la/Q03YtTq30

This study presents new tools for measuring the intracellular calcium concentration close to transmitter release sites, which may be relevant for synaptic vesicle fusion and replenishment. elifesciences.org/reviewed-prepr…

From MBoC... Tired of hand-annotating cell images? Ajit Joglekar and colleagues introduce Cell-APP, a tool that automates creating training data for cell-segmentation models—speeding up workflows and helping labs build models that fit their needs. 🔗 molbiolcell.org/doi/10.1091/mb…

Leanna Owen, Margot Riggi, David Drubin, Janet Iwasa and Yidi Sun use molecular animation to depict the full progression of CME in budding yeast, with an accompanying Cell Science at a Glance article and poster. journals.biologists.com/jcs/article/13…

KJ Muldoon, at less than a year old, was the first known person to receive a personalised CRISPR-based genome-editing therapy He is part of Nature’s 10, a list of people who shaped science in 2025 go.nature.com/48Jm1M4

Endoplasmic reticulum disruption stimulates nuclear membrane mechanotransduction nature.com/articles/s4155…

.@ElMossadeq, Dumont et al. show that an interkinetic envelope surrounds chromosomes between #meiosis I and II in #Celegans oocytes. hubs.la/Q03V-Xb20 📕 From The Year In Cell Biology: hubs.la/Q03V-VvW0 #CellBio2025