Tim Willinger lab

Great collaboration with the labs of @bart_lambrecht and @gigaipl

Congratulations to PhD student @laura_bub_ and other members of my lab who contributed to the study.

(3) Our study provides a mechanism of how the loss of tissue-resident macrophages is sensed and establishes the new concept that metabolic cues from the tissue microenvironment instruct the differentiation of recruited monocytes into lung macrophages.

(2) We found that fibroblasts produce 7alpha,25-dihydroxycholesterol in response to resident macrophage depletion, which recruits monocytes via the oxysterol receptor GPR183 to replenish macrophage niches in the lung.

(1) We used single-cell RNA-sequencing and new macrophage depletion models to identify niche-derived signals that promote monocyte-derived macrophages.

We discovered that cholesterol metabolites (oxysterols) recognized by the receptor GPR183 attract monocytes to repopulate depleted lung macrophage niches.

Happy to see our paper published in JEM: doi.org/10.1084/jem.20…

Online now: Innate type 2 lymphocytes trigger an inflammatory switch in alveolar macrophages dlvr.it/TPmLPM

Online now: MafB is a conserved transcriptional regulator of macrophage development and functional identity across tissues and species dlvr.it/TRB67C

It was fun to reconnect with old friends and colleagues at Yale 😀😎

Amazing how Richard is still going strong!

It was great to present our latest work on lung macrophages at the Richard Flavell Symposium.

Submit your abstract for EMIG 2025 at emig2025.de Deadline is 30 April.

Registration for #EMIG2025, the European Mucosal Immunology Group meeting in Aachen, Germany is now open. Save your spot today: emig2025.de

Very proud see former PhD student @elzaevren at the Conferment Ceremony @karolinskainst

Lots of interesting scientific discussions with engaged students 😀

Enjoyed running the 4th edition of our Mucosal Immunology doctoral course @karolinskainst together with @ejvillablanca

Having fun at the #ICMI2024 party last night!

It was fun to present our recent work on lung macrophages at #ICMI2024

Excited to see #ICMI2024 happening in Copenhagen right now! Thanks to my co-chairs @williamagace and @katha_lahl