deWitLab

You may know ZNF143 as a looping factor. We show together with the @hansen_lab that this is not the case! If you want to know why and what it does instead do read our thread below: biorxiv.org/content/10.110…

📢 We are very excited to announce the first International Dutch Embryo Model Meeting in Nijmegen on March 27-28. See below for details. Don't miss this fantastic opportunity to connect with the embryo model community!

Come and join us!

Check out our latest review on how cooperativity influences transcriptional bursting. Kudos to the first author Charis Fountas! sciencedirect.com/science/articl…

Delighted to see the completed Special Issue of Current Opinion in Genetics and Development on "Genome Architecture and Expression” It was a pleasure putting this together with Maya Capelson. Thanks to all the authors that contributed articles sciencedirect.com/special-issue/…

@Anders_S_Hansen @NIH_CommonFund Wow, congrats! Hope this leads to loads of cites 😆

Very grateful to @NIH_CommonFund for funding our Transformative Research Award #NIHHighRisk

The protein factories of our cells are much more diverse than we thought. NKI scientists have shown that cancer cells can use ribosomes to boost their invisibility, helping them hide from the immune system. They publish their findings in Cell today ➡️ bit.ly/4ePmIVW

Researchers from the Netherlands Cancer Institute and @prinsesmaximac are launching a new study looking into rhabdoid tumors, a rare and highly aggressive form of childhood cancer, thanks to financial contributions from @kika8118 ➡️ bit.ly/3zPw9Wc

Happy to share work with Hadi, Yao & @Maxime_Tortora characterizing the impact of dynamic CTCF barriers for cohesin loop extrusion biorxiv.org/content/10.110…

Want to do a DPhil @BiochemOxford ? Here is a link (#collapse866586" target="_blank" rel="nofollow noopener">bioch.ox.ac.uk/graduate-about…) to programmes that admit students. Great labs to choose from. Have a look at kloselab.co.uk if you want to know more what we do in my group! Please RT!

🚨🚨🚨 Call is now open!!! Wanna become our new beloved colleague 🫶🏻🫶🏻🫶🏻 and be part of a stimulating (and friendly) scientific community ??? We are perfectly located in beautiful Paris with exciting work environment and state-of-the-art core facilities APPLY 👇🏻👇🏻👇🏻👇🏻

👀 We're looking for a junior group leader! Join our innovative, curiosity-driven institute in a collaborative, international environment. Full freedom to pursue your research, competitive salary & relocation support. 📅 Apply by Dec 1 Info & application: bit.ly/3BLA3j8

@NicolaFestuccia On Oct 4 no less, congrats!

Our work establishing the orphan nuclear receptor NR5A2 as an essential regulator of early mouse development is finally out! We show that NR5A2 is required for the development of a viable morula. doi.org/10.1126/scienc…

First preprint from the lab 🚨 How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process? biorxiv.org/content/10.110… (1)

Paper 🚨! Ecstatic, proud, grateful …Years of dedication from the whole lab, with the exceptional @djkloosterman and the one of a kind #JohannaErbani at its helm. What a journey all the way to @CellCellPress! How did it start (& end)? A 🧵1/n cell.com/cell/fulltext/…

(1/16) Check out our @SimonMJGaudin paper tiny.cc/icuazz from the Canzio lab out in @ScienceMagazine today on how tuning local cohesin trajectories enables differential readout of the clustered Protocadherin (Pcdh) locus across different types of neurons.

I'm #hiring a PhD student! Join the Lindeboom Lab at the @NKI_nl on an exciting project to explore oncogenic transcription factor binding kinetics and biophysics using state-of-the-art technologies! Apply now or share this exciting opportunity! nki.nl/careers-study/…

Immunotherapy before surgery for patients with metastatic melanoma appears to be successful as 59% of patients responds so well that adjuvant treatment is no longer needed, show the results of the NADINA trial presentend at #ASCO24 today by @ProfCUBlankNKI bit.ly/3Vo1hnn

Might attempt to model a flotillin cage using the AlphaFold3 web server was super fun (original paper: biorxiv.org/content/10.110…). Read the thread for a crazy plot twist!🧵👇

Demis -- I think AlphaFold3 is really exciting. As Reviewer #3, I got great results from the server. I tried hard to get @Nature to urge you to release the code but was unsuccessful. I did not get it for re-review so I don't know if you responded. So why no code? @GoogleDeepMind

Interested in using degron tagging to study the function of your favourite protein in genetically engineered mouse models? Check out our review covering recent work in this area: doi.org/10.1242/dmm.05…