Niraj Gupta

Well… this happened. Our recent research on brain vascular and white matter changes with aging just got covered by The Hindu! White matter isn’t just “wiring.” It reflects vascular health, resilience & biological ageing. thehindu.com/sci-tech/healt… @iamvivekt @IISER_BERHAMPUR

Day 1: An exciting start! Got the opportunity to dive into MR sequence development—so much to learn and explore ahead. @NIBBRlab @iamvivekt

All excited for the Challenging Next 5-Days at Philips knowledge Innovation Centre, Bangalore, for packed 5 days of Ideation and MR Pulse Programming and Designing Workshop and Training. @NIBBRlab @iamvivekt @IISER_BERHAMPUR

📢 Hiring | Project Research Scientist–I (Medical) If you enjoy out-of-the-box thinking, pushing beyond comfort zones, and thriving on ambitious, cutting-edge neuroscience research challenges — there’s a place for you in our group. Apply by 12th Feb @iamvivekt @IISER_BERHAMPUR

@RittikaDutta23 @biopatrika @NIBBRlab @iamvivekt @nehayadav Thanks Rittika!

Proud to see @nirajgupta02 's work feautured in @biopatrika. A compelling and insightful article on axonal pruning and brain aging-well worth the read. Congratulations!! @NIBBRlab @iamvivekt @nehayadav biopatrika.com/academia/resea…

Pleased to share that our recently published study has been featured in Biopatrika's Research Spotlight. Read it at: biopatrika.com/academia/resea… Research article: academic.oup.com/cercor/article… @NIBBRlab @iamvivekt @iiser_berham

A Happy New Year from the NIBBR Group!🎆🎊 In frame: White Matter Tracts of a Cognitively Normal Subject, from IISER Berhampur Neuroimaging Cohort, acquired at our 3T MRI. @iamvivekt @NIBBRlab @IISER_BERHAMPUR

Same pinch Niraj; Equally excited. In this study, using multiple aging cohorts- including our @IISER_BERHAMPUR aging cohort- we demonstrate that periventricular white matter hyperintensity (PVWMH) volume increases nearly twice as fast with advancing age, with a clear inflection around 61 years. We identified that a PVWMH burden exceeding 2.3 mL, independent of chronological age, is associated with selective deficits in executive, attentional, and semantic cognitive domains, along with widespread cortical and subcortical atrophy involving the nucleus accumbens, rostral middle frontal, pre/postcentral gyri, lingual gyrus, and cerebral cortex. We emphasize that we age differently because we accumulate PVWMH differently-and once this burden crosses a critical threshold, it rewires the neuroanatomic and cognitive trajectories of aging. academic.oup.com/cercor/article… Congratulations Niraj and Neha.

@MuskanMittal_11 Thankyou!

Congratulations 🎉🎉 Hard work pays off!!! Very well deserved ✨ #Neuroscience #Cognition #brainage #aging

PVWMH is visible on routine FLAIR MRI. We propose that quantitative PVWMH assessment, combined with targeted domain-specific cognitive evaluations, provides a clinically feasible framework for incorporating lesion-burden thresholds into standard MRI reporting and follow-up. (7/n)

Thrilled to announce that our paper entitled "Brain aging and cognitive decline accelerate beyond a threshold of periventricular white matter hyperintensity" is now published. Read it at: academic.oup.com/cercor/article… @iamvivekt @nehayadav1211 NIBBR Lab, @IISER_BERHAMPUR (1/n)

Deep WMH? Much less dramatic. DWMH had negligible effects compared with PVWMH. So location matters - not all WMH are equal. Think of PVWMH as damage near the central electrical hub. (6/n)

Why it matters? Once PVWMH exceeds 2.3 mL, the study found compromise in global fibre integrity; significant brain shrinkage in frontal, motor and visual areas; and deficits in attention, exec. func and semantic memory. Global screens (MMSE) barely budged - they miss this. (5/n)

WMH lesions grow exponentially with age, 2x faster near the ventricles than in deep white matter, with sharp rise at 61 years. (4/n)

What we measured: bright spots called white matter hyperintensities (WMH) on routine MRI. They come in 2 neighborhoods: PVWMH (near ventricles) and DWMH (in deep white matter). This multicohort study involved ~1500 subjects from NACC, ADNI and IISER Berhampur Aging Cohort. (3/n)

Insights: Even when cognitive tests say you're “normal”, your brain may tell a different story. Tiny small-vessel lesions, once they grow past ~2.3 mL, mark a sudden leap in brain aging-shrinking structure, slowing attention & semantic memory, and fraying axonal integrity. (2/n)

Even when cognitive tests say you're “normal”, your brain may tell a different story. Tiny small-vessel lesions, once they grow past ~2.3 mL, mark a sudden leap in brain aging - shrinking structure, slowing attention & semantic memory, and fraying axonal integrity.

Truly honored to present my research in the Young Scientist Colloquia (Tulsabai Somani Oral) at Indian Academy of Neuroscience #IAN2025. Great to see diverse and interdisciplinary neuroscience research from across India and beyond! @iamvivekt @NIBBRlab @IISER_BERHAMPUR

Thank you, ma’am. It was an honor to present my research to the neuroscience community, and I’m glad the idea and message came across clearly. @WormlockHolmes @IndAcadNeurosci #ian2025

If you're around and attending IAN 2025 conference, do visit my talk in Tulsabai Somani Award category today at 06:10 PM hosted by @RGCB_Trivandrum . @IndAcadNeurosci @IISER_BERHAMPUR