Thinking out Loud

JAMA published post hoc analysis crap like this.

@eyegenedrb @foundmyfitness Also you clearly violate randomization once you exclude people who were part of the whole.

@foundmyfitness Memory gains without global cognition changes. That's the post-hoc pattern. I'm calling this regression to the mean, not a true biological effect. Needs prospective validation.

High-dose vitamin D during pregnancy may lead to better cognitive performance in children. Mothers who supplemented with 2,800 IU/day of vitamin D had children with better verbal memory, visual memory, and cognitive flexibility at age 10 vs. children whose mothers supplemented with a standard dose of 400 IU/day.

@foundmyfitness This is so bad. What are you even talking about. Do you even understand how p-values work. How any of the stats work. How the study was conducted. The concept of experimental design. Please don’t mislead the masses.

@pitdesi All these vibe shifts back n forth between these models seem sketchy to me. I have been using gemini for a while. It’s the best bang for the buck any normal person can get. Openai and anthropic are just hype machines to make excuses to raise their tokens cost.

Feels like the vibe shifted back to OpenAI over the last month GPT5.5 is good, sick of Claude limits.

“After all, we don’t even know where life lives now, or what it is, or what it’s called. Leave us to ourselves, without our books, and we’ll get confused and lose our way at once — we won’t know what to attach ourselves to, what to hold on to, what to love and what to hate, what to respect and what to despise. We’re even oppressed by having to be human beings — human beings with our own real body and blood; we’re ashamed of this; we consider it a disgrace and attempt to be some sort of nonexistent universal human beings.” -Notes from Underground

@sacha @GaryMarcus S&p 500 is not affected much.

@GaryMarcus worse than that

time to get out of index funds? they will soon be saddled with the IPOs of three giant companies that barely make a profit (or don’t make profits at all). I don’t personally want to be part of that. (this is not however investment advice, just a question that i am raising for myself, thinking out loud.)

I took 2 500 mg THC weed an hour ago and it's only getting worse. What do I do to get rid of it? I'm super stoned

@akanoego @Paddypatman @cremieuxrecueil @paulctan @HRH_Ted x.com/rationaloptmis…

@Paddypatman @rationaloptmist @cremieuxrecueil @paulctan @HRH_Ted Yep, he literally spells it out: "1. Randomisation does not produce balance 2. This does not affect the validity of the analysis" Randomisation makes imbalance random rather than confounded. Chance imbalance affects precision and is reflected in uncertainty intervals.

Eli Lilly has done it. They've gone and made what seems to be a powerful, permanent gene therapy for LDL cholesterol. That means they'll be able to effectively prevent most heart disease with a single infusion!

@adamkvonende @Special_Cactus @paulctan @cremieuxrecueil @Paddypatman @HRH_Ted Here’s what Stephen Senn has to say in the conclusion

@adamkvonende @Special_Cactus @paulctan @cremieuxrecueil @Paddypatman @HRH_Ted Not saying randomized trials are not reliable. But to say it eliminates confounding is misleading.

@cremieuxrecueil @paulctan @Paddypatman @HRH_Ted No it doesn’t. Read this. errorstatistics.com/2020/04/20/s-s…

@paulctan @Paddypatman @HRH_Ted Randomization eliminates confounding. This is very basic knowledge. Good luck with reading!

@Special_Cactus @paulctan @cremieuxrecueil @Paddypatman @HRH_Ted That’s not the point of randomization. Here’s an actual statistician talking what it intends to do. Read it you will be surprised how much you misunderstood randomization. errorstatistics.com/2020/04/20/s-s…

@paulctan @cremieuxrecueil @Paddypatman @HRH_Ted Random assignment of treatment creates groups with similar distributions of participant characteristics (i.e. potential confounders). That’s the point. All you’re doing is repeating Bart Kay one-liners. I don’t think you understand the words you’re saying.

@_6signxxx What if slower you breathe longer you live

In fact, that’s one of the main theories explaining why organisms age and die.

It’s easy to point out when Israel fails to meet her own high (sometimes impossibly high) standards when you ignore the fact Palestine has none.

@brunellaism It’s cope all the way down anyways

noticing that everyone i meet these days myself included is coping really hard lately. lowkey it's gonna be the Summer of Cope #CopeSummer

@PaulSkallas Caffeine is just a fuel for modern corporate slavery.

Here’s the full list btw 1. Middlemarch by George Eliot 2. Beloved by Toni Morrison 3. Ulysses by James Joyce 4. To the Lighthouse by Virginia Woolf 5. In Search of Lost Time by Marcel Proust 6. Anna Karenina by Leo Tolstoy 7. War and Peace by Leo Tolstoy 8. Jane Eyre by Charlotte Brontë 9. Pride and Prejudice by Jane Austen 10. Madame Bovary by Gustave Flaubert 11. The Great Gatsby by F. Scott Fitzgerald 12. Bleak House by Charles Dickens 13. Emma by Jane Austen 14. Mrs Dalloway by Virginia Woolf 15. Moby-Dick by Herman Melville 16. Nineteen Eighty-Four by George Orwell 17. One Hundred Years of Solitude by Gabriel García Márquez 18. Persuasion by Jane Austen 19. The Life and Opinions of Tristram Shandy, Gentleman by Laurence Sterne 20. Wuthering Heights by Emily Brontë 21. The Portrait of a Lady by Henry James 22. Things Fall Apart by Chinua Achebe 23. Midnight's Children by Salman Rushdie 24. The Remains of the Day by Kazuo Ishiguro 25. Lolita by Vladimir Nabokov 26. Don Quixote by Miguel de Cervantes 27. The Trial by Franz Kafka 28. The Brothers Karamazov by Fyodor Dostoevsky 29. Pale Fire by Vladimir Nabokov 30. Frankenstein by Mary Shelley 31. The Prime of Miss Jean Brodie by Muriel Spark 32. The God of Small Things by Arundhati Roy 33. David Copperfield by Charles Dickens 34. Wolf Hall by Hilary Mantel 35. Great Expectations by Charles Dickens 36. The Handmaid's Tale by Margaret Atwood 37. Invisible Man by Ralph Ellison 38. The Age of Innocence by Edith Wharton 39. Their Eyes Were Watching God by Zora Neale Hurston 40. Song of Solomon by Toni Morrison 41. Heart of Darkness by Joseph Conrad 42. The Magic Mountain by Thomas Mann 43. Housekeeping by Marilynne Robinson 44. Giovanni's Room by James Baldwin 45. The Golden Notebook by Doris Lessing 46. The Leopard by Giuseppe Tomasi di Lampedusa 47. Vanity Fair by William Makepeace Thackeray 48. The Metamorphosis by Franz Kafka 49. A Fine Balance by Rohinton Mistry 50. Wide Sargasso Sea by Jean Rhys 51. My Brilliant Friend by Elena Ferrante 52. The Golden Bowl by Henry James 53. The Transit of Venus by Shirley Hazzard 54. Orlando by Virginia Woolf 55. The Waves by Virginia Woolf 56. Mansfield Park by Jane Austen 57. The Sound and the Fury by William Faulkner 58. Disgrace by J.M. Coetzee 59. Never Let Me Go by Kazuo Ishiguro 60. Howards End by E.M. Forster 61. The Rings of Saturn by W.G. Sebald 62. Half of a Yellow Sun by Chimamanda Ngozi Adichie 63. White Teeth by Zadie Smith 64. The Good Soldier by Ford Madox Ford 65. The Color Purple by Alice Walker 66. The Master and Margarita by Mikhail Bulgakov 67. The Man Without Qualities by Robert Musil 68. Blood Meridian by Cormac McCarthy 69. Crime and Punishment by Fyodor Dostoevsky 70. Jude the Obscure by Thomas Hardy 71. Kindred by Octavia E. Butler 72. Our Mutual Friend by Charles Dickens 73. Austerlitz by W.G. Sebald 74. Nervous Conditions by Tsitsi Dangarembga 75. The Bluest Eye by Toni Morrison 76. Dracula by Bram Stoker 77. The Rainbow by D.H. Lawrence 78. A House for Mr Biswas by V.S. Naipaul 79. Go Tell It on the Mountain by James Baldwin 80. Rebecca by Daphne du Maurier 81. Buddenbrooks by Thomas Mann 82. The End of the Affair by Graham Greene 83. A Farewell to Arms by Ernest Hemingway 84. The Talented Mr Ripley by Patricia Highsmith 85. The Vegetarian by Han Kang 86. The Turn of the Screw by Henry James 87. The Line of Beauty by Alan Hollinghurst 88. Ragtime by E.L. Doctorow 89. The Left Hand of Darkness by Ursula K. Le Guin 90. Jacob's Room by Virginia Woolf 91. Life and Fate by Vasily Grossman 92. Sentimental Education by Gustave Flaubert 93. Invisible Cities by Italo Calvino 94. The Known World by Edward P. Jones 95. The Return of the Native by Thomas Hardy 96. Pedro Páramo by Juan Rulfo 97. Catch-22 by Joseph Heller 98. The Road by Cormac McCarthy 99. The Go-Between by L.P. Hartley 100. My Ántonia by Willa Cather

Making a list of 100 greatest novels of all time is just silly. How would you even categorize them. No objective criteria exists. Art is subjective. This turns into a game of throwing opinionated darts towards one another.

Here’s the full list btw 1. Middlemarch by George Eliot 2. Beloved by Toni Morrison 3. Ulysses by James Joyce 4. To the Lighthouse by Virginia Woolf 5. In Search of Lost Time by Marcel Proust 6. Anna Karenina by Leo Tolstoy 7. War and Peace by Leo Tolstoy 8. Jane Eyre by Charlotte Brontë 9. Pride and Prejudice by Jane Austen 10. Madame Bovary by Gustave Flaubert 11. The Great Gatsby by F. Scott Fitzgerald 12. Bleak House by Charles Dickens 13. Emma by Jane Austen 14. Mrs Dalloway by Virginia Woolf 15. Moby-Dick by Herman Melville 16. Nineteen Eighty-Four by George Orwell 17. One Hundred Years of Solitude by Gabriel García Márquez 18. Persuasion by Jane Austen 19. The Life and Opinions of Tristram Shandy, Gentleman by Laurence Sterne 20. Wuthering Heights by Emily Brontë 21. The Portrait of a Lady by Henry James 22. Things Fall Apart by Chinua Achebe 23. Midnight's Children by Salman Rushdie 24. The Remains of the Day by Kazuo Ishiguro 25. Lolita by Vladimir Nabokov 26. Don Quixote by Miguel de Cervantes 27. The Trial by Franz Kafka 28. The Brothers Karamazov by Fyodor Dostoevsky 29. Pale Fire by Vladimir Nabokov 30. Frankenstein by Mary Shelley 31. The Prime of Miss Jean Brodie by Muriel Spark 32. The God of Small Things by Arundhati Roy 33. David Copperfield by Charles Dickens 34. Wolf Hall by Hilary Mantel 35. Great Expectations by Charles Dickens 36. The Handmaid's Tale by Margaret Atwood 37. Invisible Man by Ralph Ellison 38. The Age of Innocence by Edith Wharton 39. Their Eyes Were Watching God by Zora Neale Hurston 40. Song of Solomon by Toni Morrison 41. Heart of Darkness by Joseph Conrad 42. The Magic Mountain by Thomas Mann 43. Housekeeping by Marilynne Robinson 44. Giovanni's Room by James Baldwin 45. The Golden Notebook by Doris Lessing 46. The Leopard by Giuseppe Tomasi di Lampedusa 47. Vanity Fair by William Makepeace Thackeray 48. The Metamorphosis by Franz Kafka 49. A Fine Balance by Rohinton Mistry 50. Wide Sargasso Sea by Jean Rhys 51. My Brilliant Friend by Elena Ferrante 52. The Golden Bowl by Henry James 53. The Transit of Venus by Shirley Hazzard 54. Orlando by Virginia Woolf 55. The Waves by Virginia Woolf 56. Mansfield Park by Jane Austen 57. The Sound and the Fury by William Faulkner 58. Disgrace by J.M. Coetzee 59. Never Let Me Go by Kazuo Ishiguro 60. Howards End by E.M. Forster 61. The Rings of Saturn by W.G. Sebald 62. Half of a Yellow Sun by Chimamanda Ngozi Adichie 63. White Teeth by Zadie Smith 64. The Good Soldier by Ford Madox Ford 65. The Color Purple by Alice Walker 66. The Master and Margarita by Mikhail Bulgakov 67. The Man Without Qualities by Robert Musil 68. Blood Meridian by Cormac McCarthy 69. Crime and Punishment by Fyodor Dostoevsky 70. Jude the Obscure by Thomas Hardy 71. Kindred by Octavia E. Butler 72. Our Mutual Friend by Charles Dickens 73. Austerlitz by W.G. Sebald 74. Nervous Conditions by Tsitsi Dangarembga 75. The Bluest Eye by Toni Morrison 76. Dracula by Bram Stoker 77. The Rainbow by D.H. Lawrence 78. A House for Mr Biswas by V.S. Naipaul 79. Go Tell It on the Mountain by James Baldwin 80. Rebecca by Daphne du Maurier 81. Buddenbrooks by Thomas Mann 82. The End of the Affair by Graham Greene 83. A Farewell to Arms by Ernest Hemingway 84. The Talented Mr Ripley by Patricia Highsmith 85. The Vegetarian by Han Kang 86. The Turn of the Screw by Henry James 87. The Line of Beauty by Alan Hollinghurst 88. Ragtime by E.L. Doctorow 89. The Left Hand of Darkness by Ursula K. Le Guin 90. Jacob's Room by Virginia Woolf 91. Life and Fate by Vasily Grossman 92. Sentimental Education by Gustave Flaubert 93. Invisible Cities by Italo Calvino 94. The Known World by Edward P. Jones 95. The Return of the Native by Thomas Hardy 96. Pedro Páramo by Juan Rulfo 97. Catch-22 by Joseph Heller 98. The Road by Cormac McCarthy 99. The Go-Between by L.P. Hartley 100. My Ántonia by Willa Cather

The Guardian’s panel has chosen the 100 greatest novels of all time and has put BELOVED second. That is among the most ludicrous aesthetic judgments in the annals of Western culture. Embarrassing tokenism.

@craigzLiszt Funny i am finding fb more meaningful in terms of having long form conversations than this hellsite.

opening up facebook is like traveling 5 years back in time