DePace Lab

A reminder that my department at HMS is hiring! Applications due Oct. 31st. Its a great place to work, and we're excited about finding our next new colleague.

Thrilled to share our new (unredacted) report in @sciencemagazine with evidence for cooperation influencing outcomes! Led by Caleb Bashor & @nikitpatels, we built cooperative TF assemblies and showed how they enable complex signal processing in cells: science.sciencemag.org/content/early/…

@peiferlabunc @DrMattBenton @pinigrini Our goal was to rule out pair wise TF intxns giving rise to that degree of steepness. Didn't mean to imply that is a widely held view, or the best explanation. Now that we've ruled it out, we can consider other more complex mechanisms. Thx for tweets- room to improve my talk!

@pinigrini @peiferlabunc @DrMattBenton I didn’t mean to imply that everyone believes that TF DNA interactions are all or nothing or static. Clearly there are people considering other mechanisms. My point was that we can test that assumption, and rigorously rule it out. That's what models are really good for! :)

Excited to share new work from @ClarissaScholes! She measured how 2 Kr shadow enhancers combine their output using live imaging. Take home: 1 + 1 sometimes is a lot less than 2, sometimes only a little bit less. Output is not a simple function of enhancer expression level.

Excited that our review on the MZT in Drosophila is now online at Open Biology (royalsocietypublishing.org/doi/10.1098/rs…). Great work from recent PhD grad Danielle Hamm.

Undergraduates -- apply for a Summer Internship in Systems Biology! You get to explore Harvard and do cool research while being paid. sysbio.med.harvard.edu/summer-interns…

@Ella_Preger @TechnionLive Congratulations!!!

@NeedhiBhalla Congratulations!!! So well deserved!!!

Don't forget to apply to join the fabulous group of interdisciplinary students and faculty in the Harvard PhD program in Systems Biology! Deadline Dec 1. No GRE needed, application fees can be waived, stipend, tuition and health insurance included. sysbiophd.harvard.edu/prospective-st…

@FORsymp Happy to say that we will be matching the next $1000 of donations to @FORsymp! Everyone wants the standard of mentoring in academia to improve, this is a great way to start driving change. #GivingTuesday

more evidence for the functional role of Zelda hubs in mediating transcription factor binding to their targets. Really exciting to see this line of research blossoming! biorxiv.org/content/early/…

Hello #ABRCMS2018 ! Come talk to us about the Harvard PhD Program in Systems Biology! We’re in the Exhibit Hall booth 812.

1/ Our work on phased nucleosome arrays in the Drosophila genome is out: cell.com/molecular-cell… In it, we used spectral analysis to map phased arrays throughout the genome.

This is happening!! @yoginho, James DiFrisco and I have been funded by @EMBO and @FEBSnews to organise the "Venice Summer School: Mechanism in Development & Evolution". Check it out, spread the news and apply!!

The role of chromatin accessibility in cis-regulatory evolution biorxiv.org/content/early/…

Happy to finally share this (long in progress) work with the world. Lots of hard work by @gizemkly (especially), @JLachowiec, and Ulises Rosas. Redundant and cryptic enhancer activities of the Drosophila yellow gene biorxiv.org/content/early/…

It's on bioarxiv finally! In this paper we dissect a GRN into dynamical modules and use them to study the networks evovability. Give us your feedback too! It hasn't been submitted yet. @yoginho biorxiv.org/cgi/content/sh…