Feigon Lab

Highlights the awesome power of NMR and cryo-EM combined to make the "invisible" visible.

Big congratulations to current and former @FeigonLab members @YaoHe_YH @HeSong2009 HenryChan @Baocheng_Liu @YaqiangWang LukasSusac and great collaborator @zhou_lab !!!

Great to be part of today’s trifecta of @Cechlab @cijilim @FeigonLab Nature papers on telomere C-strand synthesis by CST-Pola-Primase! nature.com/articles/s4158… nature.com/articles/s4158… nature.com/articles/s4158…

Happy to share our latest paper on the cryo-EM structure of a telomere end replicon: Tetrahymena telomerase-CST-Pola-Primase. Active for coordinated G-strand and C-strand synthesis. nature.com/articles/s4158…

Happy to be at the #RNA2022 #RNA22 @RNASociety meeting to share our 7SK @AuroraYuanYang and telomerase work. Check out @Baocheng_Liu 's talk C11-10 and @YaoHe_YH 's poster PS3-496 today for telomerase. Also had a beautiful hike in Boulder!

Congratulations to @Baocheng_Liu @YaoHe_YH @YaqiangWang @HeSong05808037

Happy😊to share our work on human telomerase with shelterin protein TPP1 @Nature. Our cryo-EM structures define the determinants of telomerase recruitment by TPP1, TERT–TER interactions, and structural basis of telomerase inhibitor & telomeropathies. rdcu.be/cLheF

For LaRP enthusiasts @LarPsociety, the structures include the first full-length La-related protein.

Super excited to share our work on 7SK core RNP structures and conformational switching published @MolecularCell. These cryo-EM structures are the first for 7SK RNP, providing structural and mechanistic insights for 7SK RNP assembly and P-TEFb regulation. authors.elsevier.com/c/1ena73vVUPK7…

Beautifully written review by Michael Stone on the recent cryo-EM structures of telomerase from our lab and Nguyen's lab.

Feigon lab is excited to share our paper: Structures of telomerase at several steps of telomere repeat synthesis. Congratulations @YaoHe_YH @YaqiangWang @Baochen66151807 Christina, Lukas, and Ryan. #telomerase #cryoEM @uclachem @nature nature.com/articles/s4158…

Feigon Lab is hiring! Prospective postdocs with experience in NMR and interest in integrative structural biology of RNA or RNA-protein complexes. Applicants with expertise in crystallography or cryoEM also welcome. Email feigon@mbi.ucla.edu with CV and names of 3 refs. @nmr900

Congratulations to @yaqiangwang, @MGJones13, Lukas, @HeSong05808037 @uclachem on our new publication in PNAS. Our study shows that TERT TEN and TRAP motif have coevolved and are hallmarks of functional telomerase. doi.org/10.1073/pnas.2…

In the integrated #structuralbiology session in Max Kade Auditorium, Juli Feigon @uclachem talks about #NMR and X-ray studies of RNA-protein complexes. conference.euroismar2019.org/event/1/contri… - photo by @LindFT

Postdoc position available in #FeigonLab for experienced and motivated NMR spectroscopist interested in integrative structural biology of RNA-protein complexes. Email feigon@mbi.ucla.edu with CV and names of 3 refs.

Joining the modern age - our first tweet and first bioRxiv preprint. Structure of S. pombe telomerase protein Pof8 C-terminal domain is an xRRM conserved among LARP7 proteins biorxiv.org/content/10.110…