Helin Lab

Time to move. See you all on Bluesky: @helink.bsky.social Let's work on getting our respective institutions and our colleagues to move as well. There is an exponential increase in members on Bluesky!! theguardian.com/media/2024/nov…

Listen back to @BBCRadio4's #TheBriefingRoom to hear ICR’s Director of the Centre for Cancer Drug Discovery, Dr Olivia Rossanese @TEMT_ICR talk about preventing treatment resistance, targeted therapies, and what the future holds for cancer drugs ⤵️ 🎙 bbc.co.uk/programmes/m00…

Great start by @HelinLab at the cancer epigenetics symposium @VAInstitute vai.org/event/vai-epig…

Interested in H3K4 methylation. Then, Hua (now at Peking University) and Kristian recently shared their thoughts in a review in Trends in Cell Biology: 'Roles of H3K4 methylation in biology and disease'. authors.elsevier.com/sd/article/S09…

🎉 We're at #ExRdFest today! We're here 12-6pm today and tomorrow – come say hi and find out about #CancerResearch 👋 Find us in the Sir Alexander Fleming Building @imperialcollege, in the Creative Science zone. @CRUKConvergence #PublicEngagement #SciComm

👑We're so proud to receive a #QAPrize from Her Majesty The Queen today for our #BreastCancer research. Read more about the special event 👇 icr.ac.uk/news-archive/h…

Excellent work by Alex and Isabel. Thanks to all others who contributed to this work, including our collaborators.

🏆We’re honoured to have been granted a Queen’s Anniversary Prize👑 (@QAPrizes), the highest national honour in UK further and higher education for our innovative work in #BreastCancer. Find out more about the #QAPrize👇 icr.ac.uk/news-archive/i…

3) We also show a critical role for NSD1 in regulating cell fate transitions and transcriptional programs perturbed in Sotos syndrome. Have a look at the paper and let us know what you think!

2) We show that NSD1 both has catalytic dependent and independent roles in regulating transcription, that NSD1/H3K36me2 are enriched at enhancers, that NSD1 promotes enhancer activity and RNA Pol II pause release.

1) Interested in NSD1, Sotos syndrome and how H3K36 methylation regulates transcription? If so, please have a look at our new paper, spearheaded by Zhen Sun @zhensun24, now a postdoc in @SawyersLabMSKCC. sciencedirect.com/science/articl…

Join one of the world's leading centres for cancer #DrugDiscovery! We're making a significant investment in our Division of #CancerTherapeutics with the appointment of five new senior Faculty. Find out more about the new roles here ⬇ icr.ac.uk/media/docs/def… #ScienceJob

Position for a talented scientist to continue their work in Hematology/Leukemia Research available in our lab. Either at postdoc, senior scientific officer or staff scientist level. Please see advertisements below. jobs.icr.ac.uk/vacancies/563/…

Position for a talented scientist to continue their work in Hematology/Leukemia Research available in our lab. Either at postdoc, senior scientific officer or staff scientist level. Please see advertisements below. jobs.icr.ac.uk/vacancies/563/… jobs.icr.ac.uk/vacancies/564/…

@tim_stasevich Thank you. We will have a look.

@HelinLab Cool paper! Congrats! You might be interested in a similar effect we saw at a tandem gene array: recruitment of KDM5B led to loss of H3K4me2/3. This led to a loss in H3K27ac and reduced promoter escape (less Pol II Ser2ph compared to Ser5ph). See nature.com/articles/natur…

Interested in epigenetics and the potential function of histone modifications? If so, Hua Wang in our lab has done some beautiful work in defining a role of H3K4me3!! Check out the paper - published today. nature.com/articles/s4158…

Are you interested in how chromatin regulation affects cell phenotype and drives cancer? We have an open postdoc position in our new group @ICR_London. Join us in central London! jobs.icr.ac.uk/vacancies/544/…

@torusengoku @helin_kristian Yes, you are right. It does have an error, which was inserted during production at Nature. We have asked for a correction.

@HelinLab @helin_kristian Interesting paper! I am wondering if Fig 2e has a small error. Should it be "2h 4h 8h 24h 48h" instead of "2h 8h 24h 8h 48h"?

Please notice, deadline for applications: Nov 27th. Follow the link: jobs.icr.ac.uk/vacancies/433/…

Are you into Epigenetics and/or interested in disease, we have a number of postdoc positions available in our lab located in central London. Excellent colleagues, cool science, check out the opportunity. jobs.icr.ac.uk/vacancies/433/…