The Lehtiö Lab

@jttuusa @FehrLab I will send you an email Jussi.

@LabLehtio @FehrLab Congrats! I can't access the full-text... Does the poly-ADP-ribosylation of nsp3 or other viral proteins directly inhibit virus RNA replication... or does Mac-1 mask virus from the recognition by some TLRs (an innate immunity connection...) either restored by Mac1 inhibitor?

Mac1 inhibitor represses #SARSCoV2 replication! #PARP #drugdiscovery @FehrLab doi.org/10.1021/acs.jm…

Tutkijamme ovat onnistuneet kehittämään yhdisteen, joka estää koronaviruksen lisääntymisen ihmissoluissa. Yhdiste on tuoreiden tutkimustulosten perusteella erittäin lupaava aihio koronaviruslääkkeiden kehitykseen. #UniOulu #koronavirus @LabLehtio oulu.fi/fi/uutiset/oul…

Our paper on oligomerization of DTX3L E3 ubiquitin ligase and how this allows DTX3L-PARP9 compex to recognize ADP-ribosylated proteins is now online in Protein Science. Structure was solved with sulphur SAD @DiamondLightSou #PARP #BiocenterOulu #UniOulu dx.doi.org/10.1002/pro.49…

Our paper on #PARP HPF1 interaction inhibitors and assay is now online. Mainly some validation with full-length enzyme and activity added to the preprint version. nature.com/articles/s4159…

Small contribution from us to a collaborative study on the design of new small molecule inhibitors. Naturally using #PARP as an example. #fbmm #biocenteroulu onlinelibrary.wiley.com/doi/10.1002/mi…

Great PhD defense today by Carlos Vela Rodríguez! The opponent Vesa Hytönen guided the discussion in an outstanding manner. The custos was also present. #fbmm @UniOulu @HytonenL

@UniOulu @LabLehtio tekemälle #parp lääkeaihiokeksinnölle on myönnetty #patentti Euroopassa. Kyseessä on pienimolekyylinen kemiallinen yhdiste, joka tehostaa syövän hoitoa, kun sitä annetaan soluille yhdessä solumyrkkyjen kanssa. ➡ Lue lisää - linkki kommenteissa #oulu

A doctoral researcher position available in our team focusing on mono-ART's and their complexes. #PARP #fbmm #structuralbiology oulunyliopisto.varbi.com/en/what:job/jo…

@NiepelMario This would be likely something Bryce Paschal's team could look into.

@LabLehtio Very nice, Lari. Are you looking already how (or if) the interaction with DTX3L-PARP9 changes the function of AR, such as ubiquitination, stability, translocation, etc?

How does #DTX3L oligomerize and why is it needed? A preprint about this is online #fbmm #biocenteroulu #PARP doi.org/10.1101/2023.1…

A different kind of preprint. This is about the MSc crystallography course we organize in Oulu. Actually at the moment the R-factors start to be below 20% for some students :) #fbmm #biocenteroulu @UniOulu doi.org/10.35542/osf.i…

A preprint is available about the HTS assay to find inhibitors for #PARP HPF1 interaction developed and carefully optimized by @SaurabhSinghDh8 . We even found some early hit molecules. #drugdiscovery #FBMM #BiocenterOulu @SuomenAkatemia doi.org/10.1101/2023.1…

How DTX3L-PARP9 complex can bind dual ADP-ribosylated peptides? Nice collaboration paper with @LeidenADPr and Paschal team. #BiocenterOulu #PARP #FBMM pubs.acs.org/doi/10.1021/ac…

Saurabh is representing our team! The course is likely extremely nice based on the programme and the picture.

We have 3 doctoral researcher positions available in projects studying human mono-ADP-ribosyltransferases. These are funded by the #BiocenterOulu spearhead project and by the Research Council of Finland. @SuomenAkatemia @UniOulu #PARP #FBMM oulunyliopisto.varbi.com/en/what:job/jo…

A preprint now available for the macrodomain inhibitor which inhibits coronavirus replication. Great collaboration between teams from @UniOulu, @UnivOfKansas and @McDanielCollege #PARP #Drugdiscovery #SARSCoV2 doi.org/10.1101/2023.0…

The paper on the FRET-assay and discovery of DTX3L E3 ligase inhibitors is now published. Congrats and big thanks especially to Carlos! #BiocenterOulu #UniOulu #drugdiscovery #LifelongHealth doi.org/10.1016/j.slas…

Lloyd Ruddockille tutkimuksen kaupallistaminen näyttäytyi pitkään Tähtien sodasta tutun pimeän puolen kaltaisena pahana voimana. Nyt hän kertoo työskennelleensä jo yli vuosikymmenen ajan yritysten kanssa yhteistyössä. Mikä sai mielen muuttumaan? #UniOulu oulu.fi/fi/uutiset/aka…