Tulpule Lab

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Tulpule Lab

Tulpule Lab

@TulpuleLab

Pediatric oncologist and Physician-Scientist at MSKCC. Receptor tyrosine kinase (RTK) fusions and condensates in cancer. DNA repair. Pediatric sarcomas.

Memorial Sloan Kettering 加入时间 Nisan 2021
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Tulpule Lab
Tulpule Lab@TulpuleLab·
Beyond thrilled to share that I am moving to Memorial Sloan Kettering this fall to join #MSKKids, the Tow Center for Developmental Oncology and HOPP. The @TulpuleLab will be hiring at all levels! Can't wait to get to work. See you soon, NYC! @MSKCancerCenter
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jobRxiv
jobRxiv@jobRxiv·
The Tulpule Lab is looking for research technicians. Come spend a few years in New York City and help advance pediatric cancer research! Research Technician in NYC @TulpuleLab Memorial Sloan Kettering Cancer Center See the full job description on jobR... jobrxiv.org/job/memorial-s…
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jobRxiv
jobRxiv@jobRxiv·
Postdoctoral Fellow - Cancer Research at MSKCC @TulpuleLab The Tulpule lab at MSKCC is seeking postdocs to study pediatric cancer, biomolecular condensates, and DNA repair. To read the full job description and apply, see link in the thread! #cancer_biology #cell_signaling #...
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Tulpule Lab
Tulpule Lab@TulpuleLab·
Great summary on the impact of even a pause in NIH grant review panels. Institutions will need to respond and support research, or the shift to the private sector will accelerate (and maybe that's not a bad thing, glad to see companies dedicated to funding basic science!)
Prachee Avasthi@PracheeAC

Looks like NIH grant review panels have been suspended temporarily. Because it takes time to coordinate and schedule a multi-layered grant panel review from experts across the country, what seems like a short delay in review of funding applications could be the difference between survival and shuttering for many valuable research efforts. I started my academic research lab a year before the erratic first Trump presidency and vividly remember the uncertainty of those times. The folks starting their labs now during second term are facing similar challenges. The situation is even more precarious for more established labs that don’t have stable university startup funds remaining and require external funding to continue to pay students, postdocs, & research staff to stay open. This situation highlights that diversification of funding sources for science is good, including for the basic science that sparks so much innovation. This could mean broadening research efforts in other sectors (private for-profit or non-profit R&D). The NIH may be the largest public funder of biomedical research in the world but over-dependence on a single sector so sensitive to political winds is bad. We need nuance and creativity in how to generate value that ensures science-driven progress. Many of us in the private sector are thinking about how to grow the pie and sustain research efforts. Our scientific ecosystem needs to be much more resilient. If you’re an academic researcher worried about your fate, there is a pretty big world out there and a lot of ways to contribute your scientific expertise to advance solutions for humanity. You can invent them too. And if you’re a private entity, you can start to decrease dependence on publicly funded academic research for upstream discovery by expanding impactful basic science activities strategically and sharing more of the outputs openly. Hope this message of agency resonates with those searching for solutions and a place for their energy.

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Tulpule Lab
Tulpule Lab@TulpuleLab·
We posted a BIG update to our study on Ewing sarcoma and other FET fusion-driven cancers. FET fusion oncoproteins are aberrantly recruited to DNA breaks and cause ATM defects, which can be targeted with the ATR inhibitor elimusertib. Updates include: biorxiv.org/content/10.110…
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Tulpule Lab
Tulpule Lab@TulpuleLab·
3. Cell-line and PDX testing of the ATR inhibitor elimusertib as a synthetic lethal therapeutic strategy to target ATM defects across the class of FET rearranged tumors.
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Tulpule Lab
Tulpule Lab@TulpuleLab·
2. New mechanistic studies of the interaction/competition between EWSR1-FLI1 (the Ewing fusion) interaction with native FET proteins (i.e., EWSR1) at DNA double-strand breaks.
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MSK ScienceEducation
MSK ScienceEducation@MSKEducation·
Meet #MSKPostdoc Daniel Gracilla from the @TulpuleLab. Daniel is studying the role of FET and FET fusion proteins in altering DNA 🧬 damage response to elucidate the DNA Damage Repair vulnerability of Pediatric Sarcoma. 🇵🇭 #NPAW2024 #MSKKids
MSK ScienceEducation tweet media
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Tulpule Lab
Tulpule Lab@TulpuleLab·
Moved to NYC, started a new job, rebuilt a lab, learned to tie a bowtie.
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