Random thoughts: Humans evolved a selective system to acquire and retain a fungal metabolite that directly activates a mitochondrial sulfur enzyme. That metabolite may help preserve mitochondrial function and exercise capacity. When paired with progressive resistance training, the resulting increase in sustainable muscular work could amplify AMPK-linked mitochondrial and myokine signaling. IL-15, as a muscle-associated cytokine that supports NK and CD8 T-cell biology, may provide one bridge between skeletal-muscle fitness and cancer surveillance. fungal metabolite → human transporter → mitochondrial sulfur enzyme → muscle performance → exercise signaling → myokine biology → immune competence. Speculating 🤔 (unproven thesis) 1. Chronic foundation: Ergothioneine exposure ↓ SLC22A4/OCTN1 uptake and tissue retention ↓ MPST-associated mitochondrial sulfur/redox biology ↓ proposed support of mitochondrial function and exercise capacity 2. Weekly chemical impulses HTB + crucifers + sulforaphane ↓ Polyphenol metabolism + NRF2 + endothelial/gut effects ↓ Lower chronic noise and improved recovery environment 3. Mechanical pulse Progressive resistance training ↓ mechanical tension + energetic stress + Ca²⁺ + redox signaling ↓ AMPK / CaMK / p38 / mechanotransduction ↓ mitochondrial remodeling + hypertrophy signaling + myokine regulation ↓ possible IL-15 / IL-15Rα response 4. Immune relay IL-15 / IL-15Rα biology ↓ NK-cell and memory-CD8 support ↓ possible improvement in immune competence/cancer surveillance A selectively retained dietary compound directly activates a mitochondrial sulfur enzyme; that may improve the operating environment in which skeletal muscle trains. Progressive loading may then strengthen mitochondrial and myokine biology, with IL-15 providing one possible connection to NK and CD8 immune competence. But: IL-15 supports NK cells does not prove lifting produces enough bioavailable IL-15 to strengthen cancer surveillance. And The major theoretical downside is the same MPST/H₂S cytoprotection that might help healthy muscle could also help certain tumors or modify antitumor immunity in an unfavorable direction. Trying to build an excellent muscle-performance environment—but there is no assurance that its immune signal reaches cancer, and no assurance that cancer cannot use the same environment better than muscle does. My personal notes. Not medical advice.