تغريدة مثبتة
0xso
4.1K posts
0xso
@0xsingletonly
applied ai engineer. looking for founding engineer roles.
انضم Nisan 2022
154 يتبع1.2K المتابعون
@iScienceLuvr Any tips to validate if there’s alpha in AI x psychiatry?
English
a surprising amount of people don't understand the difference between AI in biology and AI in medicine...
i've had to explain it countless times in the past ~4 years
AI in bio - models for DNA/RNA/proteins/cells, AlphaFold, GPT-Rosalind, etc.
AI in medicine - models for clinical data, patients, clinicians, MedGemma, ChatGPT for Health, etc.
Lots of frontier labs are investing heavily in the former.
At @SophontAI and @MedARC_AI, we work on the latter.
English
@hthieblot I’ve been finding the algo posts give better short term engagement but less takeaways. Switching back to my timeline
English
It’s my most insightful tweets that gets the least view. Algo sucks
Hubert Thieblot@hthieblot
The best definition of Product-Market Fit for startups I ever heard came from @eshear when i worked for him at Twitch. Most founders think they have PMF, but they don’t. Not yet at least. Think of your startup like pushing a boulder on a steep mountain: Stage 1: The Sisyphus Phase You’re at the bottom, pushing uphill. It takes Herculean effort just to move an inch. The second you stop pushing (marketing, pushing new features), the boulder rolls back to zero. No momentum. Stage 2: The Plateau You’ve pushed it onto a flat ledge. If you stop pushing, it doesn’t roll back completely, but it doesn’t move forward either much. This is where most founders get stuck. In general, you get stuck here here without great retention and marketing you can repeat. They think this is PMF. It isn't. Stage 3: The Tipping Point Suddenly, the boulder starts moving without you. You see signups from a random user post that went viral. You can’t pinpoint where 200 new users came from. You get emails out of no where of serious customers that wants to buy your service. The market is finally pulling the product out of you. Stage 4: The Avalanche The charts go vertical. You have made it to the other side. Retention is so high that growth just happens. Stability breaks because you’re scaling faster than you can code and build systems in your company. You have unlimited capital and crisis to manage. You need to hire and fast. Every few weeks, something happens where you thought the company was done. The Reality Check: Only a tiny % of founders ever feel Stage 4. Even then, a hundred things can still kill you and some might say it's even harder to scale than to start, but at least you aren't pushing the boulder uphill anymore, it has real forward motion now. Not being alone helps A LOT with phase 1 and 2. I personally only hit true PMF twice: @CurseForge and Gamepedia. With CurseVoice, we fell into the Stage 2 trap. We reached 5M MAU, but the retention just wasn't there. We couldn't outgrow Discord because we were still "pushing the boulder" while they were riding the avalanche.
English
Especially true in consulting- we use buzz words to sell to C suite, but forget that people on the ground who will actually use our solutions
Shreyas Doshi@shreyas
A profound error that many experienced product people make is to fall into the habit of thinking & speaking at the level of clever proxies (frameworks, industry jargon, corporate buzzwords) rather than seeing the basic facts of the customer situation & identifying what matters.
English
0xso أُعيد تغريده
Worse when your manager buys into the hype and asks you to do something similar… 😂😂
Ronan Berder@hunvreus
I had hoped some AI folks would prove me wrong and that you can indeed go to bed and have "agents running while you sleep". I'd love that. All I got was a bunch of vague posts, claims from folks who are "totally doing it" or "have a friend who does this all the time". Lots of anonymous anime accounts. Lots of folks butthurt by me merely asking for something more credible than "trust me bro". I was expecting links to videos or posts from credible developers explaining how they're making it happen. I mean, stuff like what @mitsuhiko or @badlogicgames put out here all the time about how they work and which tools they use. But nope. Crickets. x.com/hunvreus/statu…
English
0xso أُعيد تغريده
My standard answer for anyone asking why the start-up ecosystem in Singapore isn't flourishing really comes down to institutionalized risk-aversion.
In Singapore, there is a "standard" path that practically everyone goes through. From age 6 to age 24, there is an institutionalized path that you are more or less constitutionally and socially mandated to follow.
If you stick within the confines of the path, you are "doing well". If you veer from this path, you get struck down as a failure. Ability to stick within the confines of the path is only a function of academic prowess.
I've lived both sides of the world first as a traditional "overachieving scholar" and then dropping out of school once I decided to walk the path less traveled. The difference in attitude from society is stark.
This breeds a mindset among most Singaporeans that there is a "correct" answer for all situations. You smell this fear of "being wrong" in all walks of life, at every layer, in all institutions.
This belief system of thinking there is a clear cut answer to all situations is entirely at odds with what is required to invoke the dark alchemy of creating something from nothing. To create a start-up, you need to be radically comfortable with being wrong and being able to iterate ruthlessly towards the correct answers.
The government however, WANTS to keep the current outcome. This mentality among society at large allows them to clip the left tails of failure, push the median up (we are, after all, highest GDP per capita in the world) and think that clipping the far right outcomes is a worthy price to pay.
To be entrepreneurial in Singapore is to literally go against institutional and societal programming.
adriel@adrielyong
as i paid my singapore taxes last weekend i realized singapore will never be a great startup hub. because everything just works too well here. it takes me sub 5 mins to file my taxes. this would have cost thousands and way more hours in the US. ride hailing and micro mobility are capped because of great public transportation. healthcare is so cheap you don’t even think about trying to AI compare / navigate care
English
0xso أُعيد تغريده
AI is terrible at ideation. This hasn't improved much even with the advent of agents.
Anyone who has asked an LLM to come up with some coding project ideas knows this. The results will usually be very unhelpful and average.
nic@nicdunz
why does ai have such bad ideas for things to do. it cannot come up with a good idea no matter how hard you try to make it
English
@datagobes @heygurisingh I find that running multiple instances of CC breaks my ability to understand the code. I’m kinda back to one CC terminal + reviewing every change
English
I’ve tried this challenge where I worked “AI-native” and with as much agent parallelism as I could cope. It may have been the longest hyperfocus ride I’ve ever been on but the crash was also hard. The information flow is quite taxing. Agentic burn-out may become a thing. Just me or people with similar experience?
English
Holy shit.
Anthropic engineers don't write code anymore.
A new hire just leaked what's actually happening inside the company shipping harder than anyone in 2026:
Nobody on his team has hand-written code in months.
They run multiple agents in parallel and act like managers, not engineers.
His exact words: "if you're just watching an agent code, you're already behind. that idle time should be spent spinning up another agent and directing it somewhere else."
The mental model isn't "use AI to code faster."
It's "you are the PM, the agents are your engineers, and your job is to keep all of them unblocked."
He called it being "fully AI aligned" as a team and said it changes what's even possible to build.
The productivity gap between people who think this way and people who don't is already enormous.
And the proof is simple:
Anthropic has shipped harder than any company in 2026.
If you're still hand-writing code, you're not behind on tools.
You're behind on the job itself.
English
are we gonna agree that openclaw was mostly hype
signüll@signulll
i’m curious what are your top 5 use cases for openclaw that you cannot live without?
English