BarabanLab

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BarabanLab

BarabanLab

@BarabanLab

Translational epilepsy research in an academic setting | neuroscience, drug discovery, zebrafish, electrophysiology, cell therapy, precision medicine and more

San Francisco, CA انضم Mayıs 2013
3K يتبع2.9K المتابعون
LifeCanvas Technologies
LifeCanvas Technologies@LifeCanvasTech·
In order to visualize MGE progenitor cell migration, the authors used LifeCanvas whole-brain mapping. This #SmartSPIM video shows extensive spread of GFP+ cells derived from MGE progenitors 60 days post-transplantation. Read the paper: bit.ly/4bNm0tB (4/4)
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nature
nature@Nature·
A researchers’ propensity for risky projects is passed down to their doctoral students — and stays with trainees after they leave the laboratory go.nature.com/4qpoyCD
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Mark Bothwell
Mark Bothwell@markbothwell·
@JoyceCarolOates My fantasy is that everyone with intelligence departs the country, leaving the illiterate, racist, and technologically challenged MAGA masses to muddle on in poverty and disease.
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Joyce Carol Oates
Joyce Carol Oates@JoyceCarolOates·
oh, no one's going. these are just wishful fantasies.
LaughAtAllOfThem@kmsitall

@JoyceCarolOates Yeh, this is the problem… all you folks picking up and leaving — leaving us to clean up your shit. It’s a cowardly act for those who are privileged to run off to a safe haven somewhere and watch from afar as your own country burns.

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Stephen C. Ekker, Ph.D.
Example of the cost of the government shutdown. The NIH study panel I'm serving was postponed. Ended up running with Dec 24, 29, and Jan 2 deadlines. My wife of 30+ years has drawn the line - no more NIH panels. She tolerated weekends, but holiday time was a bridge too far.
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The Nobel Prize
The Nobel Prize@NobelPrize·
The 2020 chemistry laureate Emmanuelle Charpentier shares her best career advice to the next generation of scientists: "The general advice I give is always to listen to oneself. It’s important to listen to oneself and follow the gut feeling, follow the intuition. In research, it is really important to follow what one likes to do. I liked different topics, and it was difficult to choose. But I think what helps a lot is just to enjoy the science and to see what the science can bring. Focus on this and really trigger the trust in oneself, the sense of curiosity of what we like to do and the joy of the science. This is important because it allows you to deal with the rest. So, they have to learn all these aspects, to see that the rest is little steps that may not work perfectly, but that, at the end of the day, make the beauty of this work. We are very privileged to be able to ask questions and work on what we like to work with." Read our full interview with Charpentier: nobelprize.org/prizes/chemist…
The Nobel Prize tweet media
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Science News
Science News@ScienceNews·
About 0.1 percent of the global population, some 8.8 million people, identifies as scientists, which means only a small fraction of people personally know a scientist. sciencenews.org/article/scient…
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Sergiu P. Pasca
Sergiu P. Pasca@Sergiu_P_Pasca·
Would be perhaps useful to point out that neural organoids are not miniature brains and that they model fetal stages of parts of the human brain during development (rather than aging or rejuvenation). At these stages, especially in cortical organoids, neural activity is largely driven by spontaneous glutamatergic release and network synchronization typical of early circuits.
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Harmony Biosciences
Harmony Biosciences@HarmonyBio·
Today, we announced that open-label extension data from Harmony Biosciences’ ongoing Phase 3 trial investigating a potential treatment of Dravet syndrome is being presented at the American Epilepsy Society Annual Meeting in Atlanta today. The data shows clinical meaningful reductions in seizure activity in participants with #Dravet syndrome along with a favorable safety profile. Learn more: bit.ly/48ZaNUQ #AES2025 #EpilepsyAwareness #ClinicalTrials #RareDisease #DravetSyndrome #Innovation #EmpathyAndInnovation
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American Epilepsy Society
American Epilepsy Society@AmEpilepsySoc·
The gavel has been passed! Many thanks to Dr. Howard Goodkin for a year of exemplary service and congratulations to Dr. Jack Parent, our incoming AES President for 2026! #AES2025
American Epilepsy Society tweet mediaAmerican Epilepsy Society tweet media
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Harmony Biosciences
Harmony Biosciences@HarmonyBio·
Earlier today, we announced that we will present new open label extension data from Harmony Biosciences’ rare #epilepsy pipeline at the 2025 American Epilepsy Society (AES) Annual Meeting. Poster presentations will highlight data in an ongoing Phase 3 clinical study for the treatment of #Dravet syndrome. Learn more: bit.ly/3MhQ85u #AES2025 #EpilepsyAwareness #ClinicalTrials #RareDisease #DravetSyndrome #Innovation #EmpathyAndInnovation
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Ubadah Sabbagh
Ubadah Sabbagh@neubadah·
save for some caveats, i agree with this. i find solace in the fact that biology is unforgiving and if your tech is built on bs hype it will eventually show. sad part is the wasted resources and ultimately, the false hope given to consumers of biotech products.
Nicole@elocinationn

There’s a belief in SF that with enough money you can solve anything. For a lot of technical companies, VCs are therefore looking for a charismatic founder who they believe will be able to get that money. In the first few rounds, they care less about the actual technical progress. VCs won’t directly tell you this but it is true, or at least revealed through their choices of who to fund. You’re seeing companies winning big rounds with no tech, followed by a scramble to acquire the people to build the tech for them. The problem with this is the word spreads quickly that you are a bit of a bullshit company amongst the people you want to hire. I’ve heard accumulating insider stuff lately that makes me believe this has gone too far. Money going to young founders or founders with no domain knowledge because they told a great story, but then technical friends go to interview there and are horrified. This is especially true on the life science side of things, where biologists are going into labs and seeing what looks like a 1st year try to do experiments and making obvious critical mistakes. Next the founder will argue with said interviewee, insisting they’re wrong only to then ask chatGPT in front of them and further humiliate themselves. Interviewee then refuses to join, and slowly finds others in their network who have done the same. Now it’s even harder for this founder to recruit anyone serious to solve their problem and they panic. Next they start to fabricate data and marketing materials. We all know where this goes. There seems to be a new bio wave coming through atm (imo GLP-1 success has renewed belief in power law outcomes). I think the challenge with life sciences in particular is the people who go into it are less financially motivated, and so to recruit them, you genuinely need to be doing excellent work and know your stuff. VCs with limited exposure to scientists may be making an error in thinking everyone has the same motivations as the average software engineer. Winning over talent for your life science company is different from software. Arguing with someone with deep technical expertise and being wrong is extremely bad for the company’s reputation and spreads fast. All this is to say is be careful. Many of these founders seems to sell a story that they’re going to do things faster and better than trad bio, but once you get in there they’re actually just doing the same thing in a much less sophisticated way. There is basically nothing new. It’s like you’re giving them money for a science project and to do a course on how to be a research assistant in a lab. For anything that’s science problem-like, make sure the founding team has someone who is respected in their field. Maybe get someone from your network with expertise to step into a lab with them and check. Granted being able to fundraise is important, this blanket rule isn’t translating as well to life sciences. They also need to be able to hire the best people.

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nature
nature@Nature·
Scientists have successfully stopped a pig kidney from being rejected by its human recipient. go.nature.com/47UIdlH
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