These 3D images (reproduced with permission from Figure S3) show how kidney progenitor cells are derived from somitic compartments (S).
Key:
n = notochord
nb = nephric bud
nd = nephric duct
nt = neural tube
An = Anterior, Po = Posterior
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LifeCanvas Technologies
520 posts
LifeCanvas Technologies
@LifeCanvasTech
Pioneering end-to-end solutions for 3D spatial biology.
Cambridge, MA Katılım Haziran 2018
387 Takip Edilen511 Takipçiler
How did vertebrates evolve kidneys? Pascal Schmidt et al. used #SmartSPIM light sheet microscopy to visualize kidney development in the catshark by mapping expression of the early pronephric marker gene PAX2, revealing a somitic origin: science.org/doi/full/10.11…
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This #MicroscopyMonday video shows whole-mount acetylated tubulin staining in a stage E10 mouse embryo, cleared with SmartBatch+ and imaged with DALISPIM as part of @MBLScience's Embryology course. Thanks Paul Maier for the sample!
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Vascular changes in the brain may also play an important part in vulnerability to Alzheimer’s & disease progression. Cerebrovascular networks are inherently continuous and interconnected, requiring a spatial, whole 🧠 approach to fully understand their contribution. (4/4)
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Neural immune cells like astrocytes and microglia play a critical role in regulating harmful protein buildup. 3D co-localization of plaques, astrocytes, and microglia helps visualize and quantify immune responses. (3/4)
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For #AlzheimersAwarenessMonth, we’re highlighting how 3D spatially-resolved data can help us understand the biology of neurodegeneration, enabling earlier diagnoses and interventions. 🧵 (1/4)
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Bring a little #MicroscopyMonday to your YouTube recommendations.
We'll be sharing new light sheet data, old favorites, free webinars, and more to our channel. Let us know what you want to see!
Subscribe to stay in the loop: @lifecanvastech" target="_blank" rel="nofollow noopener">youtube.com/@lifecanvastech
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How can the relationship b/w #Alzheimers pathology & sleep quality help us diagnose & treat the disease at earlier stages? Nicholas Constantino et al. used LifeCanvas whole 🧠 mapping to uncover a key role for microglia in amyloid-related sleep disruption: bit.ly/4vR6BPy
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We think #lightsheet microscopy can be more flexible, more scalable, and more intuitive. Meet up with us at #ELMI2026 next week to learn about our light sheet systems and our unique sample-to-data approach. 🔬🇵🇹 @PPBioImaging @EuroBioImaging @EuLiMI1
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📽️ SYFP2 expression data from Dr. Tanya Daigle & Emily Kussick, imaged with #SmartSPIM!
allen institute@AllenInstitute
Spinal motor neurons in dazzling detail. ✨ Each green dot is a spinal motor neuron - crucial but rare cells making up just 1% of neurons in the spinal cord. In diseases like ALS, they are selectively damaged, making them of special interest to neuroscientists. #SciShots
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We got to introduce the LSFM community to #DALISPIM light sheet imaging at @MDIBL last week! The excitement was palpable as we had a packed demo schedule, with students getting to see firsthand how easy DALISPIM is to use.
#MicroscopyMonday
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@YuChungPien 📖 Read the study to learn more: pnas.org/doi/10.1073/pn… (3/3)
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Yehui Sun & @YuChungPien et al. screened LNPs using human iPSC-derived cardiomyocytes, then used Clear+ #tissueclearing with #SmartSPIM light sheet microscopy to characterize biodistribution of their lead candidate throughout the whole mouse heart. (2/3)
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How can we get gene therapies to the heart more safely & effectively? 🫀 A research team led by @DJSiegwart & Eric Olson at @UTSWMedCenter has developed optimized lipid nanoparticles (LNPs) that demonstrate robust, targeted mRNA delivery & therapeutic potential 🧵 (1/3) @GDE_UTSW
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LifeCanvas Technologies retweetledi
#JNeurosci: Adkins et al. explored how binge alcohol exposure and protracted abstinence impact the S1-insular circuit in mice, revealing how alcohol can reshape sensory processing to drive alcohol use disorder-related behavior.
doi.org/10.1523/JNEURO…
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Calling all SmartBatch+ users! Have you validated a new antibody or tissue type?
Send us proof and receive 15% off your next reagent order for 1 new validation, or 25% off for 2+ validations.
📆 Submit your data by June 17th: bit.ly/4ekYzsj
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The quality of your #lightsheet 🔬 data is directly dependent on how your sample was prepared. This video shows a general comparison of some popular #tissueclearing methods, followed by Clear+ results from several mouse tissue types.
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If you're going to @LSFM_NA at @MDIBL next week, you can check out DALISPIM in person and get a hands-on demo!
LifeCanvas Technologies@LifeCanvasTech
What tissue type do you study? DALISPIM makes #lightsheet imaging simple + scalable for... 🧫 Organoids and other #NAMs 👥 Human clinical tissue samples 🐁 Rodents and other animal models These were all imaged directly in multiwell plates! #FluorescenceFriday #microscopy
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