Mehak Bassi, MD, DipABOM

Thought-provoking Q w #ASUC convo @joshsteinbergMD ?Why wait for CS failure to start effectiveRx ?Will JAKi replace TNFi: lower💰, easier access🏥 & out ?Can we manage select pts outside🏥 @ibddoctor 🌟#PatientExperience of surgical journey @LoriPlung 💎#IBDAlgo @AimenKhanMD👇🏽

Is there a role for random biopsy in IBD dysplasia surveillance? Yes in select groups per @Realcecum @GuildConference

ACG mourns the loss of James Van Der Beek, who recently passed from colorectal cancer at the young age of 48. Tragically, colorectal cancer is the #1 cause of cancer death in those under 50. If you are 45+, talk to your doctor about getting screened. ➡️ gi.org/coloncancer

@IBDimmunology @DCharabaty @MondayNightIBD @abbvie @JNJInnovMed @TakedaPharma @DavidFaleckMD @JHashashMD @fudmanMD @FunchainMD @ibdtweets @IBD_JohnD @EugeneYenMD @JeanFredericCo1 @DrsMeena @clivejmiranda @datadriven_tdoc @IBD_FloMD @MLongMD @DavidHudesmanMD @shannonchangmd @SimonHongMD @HolmerMd @DrMikeDolinger @ryanungaro @AdamFayeMD @EdwardLoftus2 @EdBarnesMD @BenClickMD @tommasoparigi @AndresYarur @ownyourcrohns @JustinFieldMD @MeganMurphyGI @AmyStewartNP @LindsayClarkeMD @KDeFelice_IBD @AimenKhanMD @EdithHoMD @IBD_DrEMF @IBDPharmD @ElisaBodenIBDMD @SalamBachour @RahulSDalalMD @md_ayanna Another plug for #SAPPHIRE Send us your patients with #IBD and #Cancer !! Ongoing @HelmsleyTrust and @CrohnsColitisFn sponsored study @nyulangone @MountSinaiNYC @MSKCancerCenter

@IBDimmunology @DCharabaty @MondayNightIBD @abbvie @JNJInnovMed @TakedaPharma @DavidFaleckMD @JHashashMD @fudmanMD @FunchainMD @ibdtweets @IBD_JohnD @EugeneYenMD @JeanFredericCo1 @DrsMeena @clivejmiranda @datadriven_tdoc @IBD_FloMD @MLongMD @DavidHudesmanMD @shannonchangmd @SimonHongMD @HolmerMd @DrMikeDolinger @ryanungaro @AdamFayeMD @EdwardLoftus2 @EdBarnesMD @BenClickMD @tommasoparigi @AndresYarur @ownyourcrohns @JustinFieldMD @MeganMurphyGI @AmyStewartNP @LindsayClarkeMD @KDeFelice_IBD @AimenKhanMD @EdithHoMD @IBD_DrEMF @IBDPharmD @ElisaBodenIBDMD @SalamBachour @RahulSDalalMD @md_ayanna @ibddoctor @DrPhil_Gu @AGA_Gastro @MichaelKappel12 Let's say it was a PAST melanoma. Some encouraging data from #SAPPHIRE cghjournal.org/article/S1542-…

@DrJordanAxelrad @DCharabaty @MondayNightIBD @abbvie @JNJInnovMed @TakedaPharma @DavidFaleckMD @JHashashMD @fudmanMD @FunchainMD @ibdtweets @IBD_JohnD @EugeneYenMD @JeanFredericCo1 @DrsMeena @clivejmiranda @datadriven_tdoc @IBD_FloMD @MLongMD @DavidHudesmanMD @shannonchangmd @SimonHongMD @HolmerMd @DrMikeDolinger @ryanungaro @AdamFayeMD @EdwardLoftus2 @EdBarnesMD @BenClickMD @tommasoparigi @AndresYarur @ownyourcrohns @JustinFieldMD @MeganMurphyGI @AmyStewartNP @LindsayClarkeMD @KDeFelice_IBD @AimenKhanMD @EdithHoMD @IBD_DrEMF @IBDPharmD @ElisaBodenIBDMD @SalamBachour @RahulSDalalMD @md_ayanna @ibddoctor @DrPhil_Gu @AGA_Gastro @MichaelKappel12 In the poll - interesting that most would stop IFX. What’s the absolute risk of aTNF WORSENING melanoma? If abs risk low + oncology ok - why not continue? Agree with @datadriven_tdoc this is the key question for me.

@DCharabaty @MondayNightIBD @abbvie @JNJInnovMed @TakedaPharma @DavidFaleckMD @JHashashMD @fudmanMD @FunchainMD @ibdtweets @IBD_JohnD @EugeneYenMD @JeanFredericCo1 @IBDimmunology @DrsMeena @clivejmiranda @datadriven_tdoc @IBD_FloMD @MLongMD @DavidHudesmanMD @shannonchangmd @SimonHongMD @HolmerMd @DrMikeDolinger @ryanungaro @AdamFayeMD @EdwardLoftus2 @EdBarnesMD @BenClickMD @tommasoparigi @AndresYarur @ownyourcrohns @JustinFieldMD @MeganMurphyGI @AmyStewartNP @LindsayClarkeMD @KDeFelice_IBD @AimenKhanMD @EdithHoMD @IBD_DrEMF @IBDPharmD @ElisaBodenIBDMD @SalamBachour @RahulSDalalMD @md_ayanna @ibddoctor @DrPhil_Gu @AGA_Gastro @MichaelKappel12 #Melanoma risk is tightly linked with UV-induced DNA damage, and #antiTNF may impair clearance of UV-damaged keratinocytes and melanocytes... as a possible mechanism. But not all data are consistent. Here's a MA from @JAMADerm showing no association: pubmed.ncbi.nlm.nih.gov/32432649/

@DrJordanAxelrad @MondayNightIBD @abbvie @JNJInnovMed @TakedaPharma @DavidFaleckMD @JHashashMD @fudmanMD @FunchainMD @ibdtweets @IBD_JohnD @EugeneYenMD @JeanFredericCo1 @IBDimmunology @DrsMeena @clivejmiranda @datadriven_tdoc @IBD_FloMD @MLongMD @DavidHudesmanMD @shannonchangmd @SimonHongMD @HolmerMd @DrMikeDolinger @ryanungaro @AdamFayeMD @EdwardLoftus2 @EdBarnesMD @BenClickMD @tommasoparigi @AndresYarur @ownyourcrohns @JustinFieldMD @MeganMurphyGI @AmyStewartNP @LindsayClarkeMD @KDeFelice_IBD @AimenKhanMD @EdithHoMD @IBD_DrEMF @IBDPharmD @ElisaBodenIBDMD @SalamBachour @RahulSDalalMD @md_ayanna @ibddoctor @DrPhil_Gu @AGA_Gastro @MichaelKappel12 . @DrJordanAxelrad how do you explain to pts the potential ⬆️ risk of melanoma w IFX, and the relative safety of using IFX to treat ICI-colitis ?

@DCharabaty @MondayNightIBD @abbvie @JNJInnovMed @TakedaPharma @DavidFaleckMD @JHashashMD @fudmanMD @FunchainMD @ibdtweets @IBD_JohnD @EugeneYenMD @JeanFredericCo1 @IBDimmunology @DrsMeena @clivejmiranda @datadriven_tdoc @IBD_FloMD @MLongMD @DavidHudesmanMD @shannonchangmd @SimonHongMD @HolmerMd @DrMikeDolinger @ryanungaro @AdamFayeMD @EdwardLoftus2 @EdBarnesMD @BenClickMD @tommasoparigi @AndresYarur @ownyourcrohns @JustinFieldMD @MeganMurphyGI @AmyStewartNP @LindsayClarkeMD @KDeFelice_IBD @AimenKhanMD @EdithHoMD @IBD_DrEMF @IBDPharmD @ElisaBodenIBDMD @SalamBachour @RahulSDalalMD @md_ayanna @ibddoctor @DrPhil_Gu Data suggest a modest ↑ melanoma risk in IBD. Here's a @AGA_Gastro paper from @MLongMD @MichaelKappel12 showing increased risks of melanoma in patients with #IBD. gastrojournal.org/article/S0016-…

@DrJordanAxelrad @MondayNightIBD @abbvie @JNJInnovMed @TakedaPharma @DavidFaleckMD @JHashashMD @fudmanMD @FunchainMD @ibdtweets @IBD_JohnD @EugeneYenMD @JeanFredericCo1 @IBDimmunology @DrsMeena @clivejmiranda @datadriven_tdoc @IBD_FloMD @MLongMD @DavidHudesmanMD @shannonchangmd @SimonHongMD @HolmerMd @DrMikeDolinger @ryanungaro @AdamFayeMD @EdwardLoftus2 @EdBarnesMD @BenClickMD @tommasoparigi @AndresYarur @ownyourcrohns @JustinFieldMD @MeganMurphyGI @AmyStewartNP @LindsayClarkeMD @KDeFelice_IBD @AimenKhanMD @EdithHoMD @IBD_DrEMF @IBDPharmD @ElisaBodenIBDMD @SalamBachour @RahulSDalalMD @md_ayanna Tough case @DrJordanAxelrad if IFX level are ok I would stop AZA to ⬇️IS- knowing that pts w IBD are at ⬆️risk of ICI-colitis, is there an advantage to optimize IFX dose to achieve a Mayo 0= Does better UC control ⬇️ risk of ICI-colitis ? @ibddoctor @IBDimmunology @DrPhil_Gu

@MondayNightIBD @DCharabaty @abbvie @JNJInnovMed @TakedaPharma @DavidFaleckMD @JHashashMD @fudmanMD @FunchainMD @ibdtweets @IBD_JohnD @EugeneYenMD @JeanFredericCo1 @IBDimmunology @DrsMeena @clivejmiranda @datadriven_tdoc @IBD_FloMD @MLongMD @DavidHudesmanMD @shannonchangmd @SimonHongMD @HolmerMd @DrMikeDolinger @ryanungaro @AdamFayeMD @EdwardLoftus2 @EdBarnesMD @BenClickMD @fudmanMD @tommasoparigi @AndresYarur @ownyourcrohns @JustinFieldMD @MeganMurphyGI @AmyStewartNP @LindsayClarkeMD @KDeFelice_IBD @AimenKhanMD @EdithHoMD @IBD_DrEMF @IBDPharmD @ElisaBodenIBDMD @SalamBachour @RahulSDalalMD @md_ayanna

@MondayNightIBD @DCharabaty @abbvie @JNJInnovMed @TakedaPharma @DavidFaleckMD @JHashashMD @fudmanMD @FunchainMD @ibdtweets @IBD_JohnD @EugeneYenMD @JeanFredericCo1 @IBDimmunology @DrsMeena @clivejmiranda @datadriven_tdoc @IBD_FloMD @JHashashMD @MLongMD @DavidHudesmanMD @shannonchangmd @SimonHongMD @HolmerMd @DrMikeDolinger @ryanungaro @AdamFayeMD

@MondayNightIBD @DCharabaty @abbvie @JNJInnovMed @TakedaPharma @DavidFaleckMD @JHashashMD @fudmanMD @FunchainMD @ibdtweets @IBD_JohnD @EugeneYenMD 37F UC pancolitis >10 yrs, on IFX 5mg/kg q4 weeks + AZA 150mg, now dx with skin #melanoma (IIIB). CLN: Mayo 1 panUC, 1cm adenoma/LGD in sigmoid resected. She is planned for neoadjuvant #pembrolizumab + surgery+ adjuvant pembrolizumab x1 year How would you manage her UC therapy?

Kicking off 2026 w 🎯#IBD & cancers ✅#Back2Basics Jan26 @DaniyalRaza92 @AimenKhanMD 🔺IBD-assoc CA 🔺Rx-assoc CA 📌Convo Feb2 w @DrJordanAxelrad 🆓#CME mnibd.short.gy/25-26 🗳️CME IBDpolls👇🏽 Support by edu grants @Abbvie @JNJInnovMed @TakedaPharma 📍Where are you in your🩺

#PreB2B #IBDPoll1️⃣ 🆓#CME👉🏽mnibd.short.gy/25-26 🔺Which of the following is the strongest risk factor for colorectal cancer in #IBD ?

#PreB2B #IBDPoll2️⃣ 🆓#CME👉🏽mnibd.short.gy/25-26 27 y/old male w moderate UC, not better on 5ASA. EBV serology negative. You discuss options, & his main concern is the potential risk of malignancy with advanced therapies. 🔺Which MOA carries the Highest risk of #lymphoma?

@MondayNightIBD 3/🚨Why does cancer risk matter in #IBD? 📊IBD assoc. with⬆️ risk of GI-CA ⚖️IBD therapy–associated CA & risk of under-treating🔥 👴 General cancer risk ⬆️ with age — a key concern in older IBD patients

@MondayNightIBD @DrJFeuerstein @AdamFayeMD @HolmerMd @JHashashMD @DrJordanAxelrad @kehutchins77 @YeseniaGreeff @IBDBen @GCalderonMD @ReezwanaCMD 4/🔥Chronic Inflammation-driven CA in #IBD 📈 CRC: 1.1–5.4% at 20 yrs (IR 10–50/10k PY) 🧬 Small bowel adenoCA: 0.2% at 10 yrs (ileal CD) 🩸 Intestinal lymphoma: IR ~1/10k PY ⚠️ Anal CA (perianal CD): 1–2/10k PY 🧠 PSC → cholangioCa: ~10% at 10 yrs

@MondayNightIBD @DrJFeuerstein @AdamFayeMD @HolmerMd @JHashashMD @DrJordanAxelrad @kehutchins77 @YeseniaGreeff @IBDBen @GCalderonMD @ReezwanaCMD @Realcecum @SophieBalzoraMD @ptandonGI @Y_ECCO_IBD @IBD_FloMD @MN_GIMD @IBDMD @tinahamd @ibdgijami @FarrayeIBD 5/Colorectal CA in #IBD is driven by chronic colonic inflammation. With modern therapies, risk has ⬇️: ~1% at 10 yrs, ~2% at 20 yrs, ~5% >20+ yrs. 🔍 High-quality surveillance is key. ⚠️ Highest risk: long duration, extensive colitis & PSC++ @AGA_Gastro 🔗gastrojournal.org/article/S0016-…

@MondayNightIBD @DrJFeuerstein @AdamFayeMD @HolmerMd @JHashashMD @DrJordanAxelrad @kehutchins77 @YeseniaGreeff @IBDBen @GCalderonMD @ReezwanaCMD @Realcecum @SophieBalzoraMD @ptandonGI @Y_ECCO_IBD @IBD_FloMD @MN_GIMD @IBDMD @tinahamd @ibdgijami @FarrayeIBD @AGA_Gastro @AasmaShaukatMD @DrDavidLarson @UGrewalMD @SultanShazi @GloverQuarshie @Adel_Hajj_Ali @gnioannou 6/#SmallBowel CA in #Crohns 🔺Relative risk higher vs non-IBD🔹Absolute risk still low ⬆️Risk: ileal disease, stricturing/penetrating CD ⚠️Difficult to dx by imaging, Often dx @ time of Sx for perf or SBO ⚠️Keep a high index of suspicion @Gut_BMJ doi.org/10.1136/gutjnl…