JAMA Dermatology

Intralesional interleukin-2 immunotherapy produced an 81% complete response rate with only mild adverse events in patients with high-risk #SquamousCellCarcinoma not eligible for surgery. ja.ma/3NP2Z08

Eosinophilic fasciitis (EF) is a rare disease in which the fascia, the tissue that covers the muscles, becomes inflamed. 📄 This Patient Page describes the symptoms, diagnosis, and treatment of eosinophilic fasciitis. ja.ma/4kZtHiZ

Lutikizumab at 300 mg weekly or every other week improved clinical outcomes compared with placebo in adults with moderate to severe #HidradenitisSuppurativa who experienced anti–tumor necrosis factor therapy failure. ja.ma/3PtIuXg

Once-daily oral ICP-332, a tyrosine kinase 2 inhibitor, showed favorable safety and significantly improved disease severity versus placebo in adults with moderate to severe #AtopicDermatitis. ja.ma/4kZtAnz

In 2025, JAMA Dermatology evaluated >3,400 manuscript submissions and maintained an Impact Factor of 11. Read the full “JAMA Dermatology—The Year in Review, 2025,” by Editor in Chief Kanade Shinkai, MD, PhD. ja.ma/4uAxmbj

📃 Case report describes a man in his 90s with granulomatous dermatitis successfully treated with topical delgocitinib. ja.ma/3MBMgwZ

A man in his 50s presented with a 4-mo history of pruritic, verrucous lesions on the right lower leg. What is your diagnosis? Take the Clinical Challenge: ja.ma/4bou9Tf

#HidradenitisSuppurativa is associated with increased risks of self-harm and suicide, highlighting the importance of clinician vigilance and multidisciplinary mental health support. ja.ma/3ZZQmSD

A man in his 50s presented with a 4-mo history of pruritic, verrucous lesions on the right lower leg. What is your diagnosis? Take the Clinical Challenge: ja.ma/4aRXple

A woman in her 30s presented with a chronic, painful, nonhealing ulcer on her fifth finger that developed after trauma 1 year earlier. What is your diagnosis? ja.ma/3MMtzqa

Among patients previously treated for early-stage #Melanoma, nearly half reported fear of recurrence and 20% had not performed skin self-examination in the prior year; half lacked confidence in skin self-examination. ja.ma/4sfbnEC

In a clinic-based survey, patients demonstrated variable understanding of skin cancer–related terminology, with only 64.2% correctly identifying "clear margins" and 21.6% understanding "dysplastic nevus." ja.ma/4al9sZp

Nearly 20% of acral lentiginous melanoma cases lacked the parallel ridge pattern, highlighting the need for improved diagnostic criteria and supporting the expansion of evidence-based dermoscopic benchmarks for early detection. ja.ma/4aGOLap

A man in his 50s developed broad-spectrum abnormal localized photosensitivity syndrome, presenting as recurrent sun-induced, site-specific erythematous plaques confirmed by targeted phototesting. ja.ma/4cvC0Ra

Systematic review: Accurate classification of dermatologic conditions using International Classification of Diseases (ICD) codes is essential for research that uses large administrative datasets. ja.ma/4axtkan

The TIP-CA model uses five clinical factors—including TIF1-γ antibody status, interstitial lung disease, poikiloderma, DM subtype, and anemia—to stratify cancer risk in DM patients. ja.ma/4tzEC6V

This case report describes a woman in her 20s with a history of linear morphea diagnosed in childhood who presented with disease progression despite long-term treatment. ja.ma/3OfMH0k

Systematic review & meta-analysis identifies diclofenac and silymarin as the most efficacious interventions for the prevention of hand-foot syndrome, with diclofenac having the best supporting evidence based on both effect size & study quality. ja.ma/3MLSvhO

For patients with stage IA to IIC #Melanoma, time to recurrence was associated not only with ulceration and thickness but also with tumor location, mitoses, neurotropism, and lymphovascular invasion. ja.ma/40OakzR

The Ectropion Severity Score demonstrated excellent reliability in grading ectropion across genotypes in epidermal differentiation disorders, with highest severity observed in TGM1-nEDD and ABCA12-nEDD. ja.ma/4aVBhWZ