It is always insightful talking with Mark and we had a chance to talk about some of our newest research and also the trajectory that led to this research being possible.
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The Betley Lab at UPenn
45 posts
The Betley Lab at UPenn
@BetleyLab
The Betley lab at Penn is focused on understanding how signaling between the body and the brain control our needs and behaviors and ultimately our health.
Philadelphia, PA انضم Aralık 2024
87 يتبع143 المتابعون
The most fun hour of my week!
I had the privilege to join @MarkMattson’s podcast “BRAIN PONDERINGS” this week!
youtube.com/watch?v=4e7bpA…
There are many insightful discussions with world leaders on this podcast – a treasure trove of information!
YouTube
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Thanks also to Mark Hargreaves, Dayu Lin, and Alan Watts for insightful comments and their time to meet with Bethany.
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Excited to share a recent national geographic article on the brain and exercise that highlights our research! Super grateful to Bethany Brookshire for her enthusiastic, tireless, and thoughtful article.
nationalgeographic.com/health/article…
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Thanks to Nathi Magubane and the Penn Today team for the write up on our recent study!
We are excited to see where this leads!
penntoday.upenn.edu/news/no-brain-…
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@hubermanlab @Brady_H While the field suggests the VMH has intermingled neurons that are involved in rage and mating, some of our experiments suggest they might not be so clearly defined. Plus, anabolic steroids also have side effects of...rage and sex drive changes? Maybe brain doping is possible???
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Very cool indeed. Covered in an upcoming HLP. VMH is loaded with neurons controlling rage and mating too & it’s salt and pepper mix so I doubt there will ever be direct and selective stimulation methods for humans but the neural aspect to exercise adaptation is a fundamental takeaway. And makes sense.
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This study is already my candidate for “coolest scientific finding of the year.”
It finds that the brain—specifically a set of neurons in the ventromedial hypothalamus (VMH)—is a key intermediate for improvements in endurance capacity.
1. Exercise strengthens inputs to and increases the activity of these SF1 neurons in the VMH.
2. Activation of SF1 neurons following exercise is required to improve endurance.
3. Exogenous activation of SF1 neurons following exercise enhances endurance gains (while inhibition of them diminishes adaptations).
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@Brady_H finding the unexpected is always remarkable. We are glad everyone is finding this fascinating. Next step...figure out if this can indeed be brain doping for exercise.
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More exciting work is happening in this space – stay tuned! But intrigued by how we can harness this for human health!
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Thanks for highlighting our work – we realized that the brain was central to exercise when we first observed how active it becomes after exercise.
Brady Holmer@Brady_H
This study is already my candidate for “coolest scientific finding of the year.” It finds that the brain—specifically a set of neurons in the ventromedial hypothalamus (VMH)—is a key intermediate for improvements in endurance capacity. 1. Exercise strengthens inputs to and increases the activity of these SF1 neurons in the VMH. 2. Activation of SF1 neurons following exercise is required to improve endurance. 3. Exogenous activation of SF1 neurons following exercise enhances endurance gains (while inhibition of them diminishes adaptations).
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Read the full report 📄 cell.com/neuron/fulltex…
DOI: 10.1016/j.neuron.2025.12.033
Congrats to first authors Morgan Kindel & Ryan Post + all collaborators!
#Neuron #Neuroscience #Exercise
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With repeated training, this VMH SF1 circuit strengthens (anatomically + physiologically).
This increase in post-exercise activity of SF1 neurons is required for endurance improvements.
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🧠🏃New in Neuron (open access): “Exercise-induced activation of VMH SF1 neurons mediates improvements in endurance”
Finally able to share what we learned about the brain & exercise 🧵
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The Betley Lab at UPenn أُعيد تغريده
Exercise pumps up your muscles — but it might also be pumping up your neurons
go.nature.com/4qxrMmC
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Some regions of interest to our lab are highlighted. Tomorrow, we will be sharing with the world, some of what we have learned about how the hypothalamic activation effects metabolism and adaptation after exercise! Stay tuned…
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We found a massive upregulation of neural activity (via Fos, indicated by more red) throughout the brain! In the video, you can see the brainwide changes observed in an exercised animal compared to a sedentary control.
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This is your brain.
This is your brain on exercise.
This dataset collected over 5 years ago captivated our neuroscience lab.
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What’s brewing in the Betley Lab at UPenn? ☕️🧠 Thrilled to welcome Elisa Caffrey! Elisa studies fermented foods and the microbes/metabolites they produce—how do they shape our bodies and brains after we eat? Excited for this new frontier!
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Always fun to collaborate with the Thaiss Lab and excited about what’s next. If you’re interested in how the gut rapidly sends health signals to the brain, read the review: authors.elsevier.com/c/1mUfe3BtfHC-… #gutbrainaxis #interoception
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Where this gets exciting: we outline steps toward “interoceptomimetics”, aka molecular interventions designed to stimulate the right body↔brain signaling and restore organismal balance.
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The gut isn’t just digestion! It is a sensory organ that reports our internal state to the brain in real time. In our new Neuron review, we dive into “intestinal interoception”: how gut signals tune physiology + behavior.
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