Tim Blower

Postdoc position now open in my lab at New England Biolabs. Focus is on exploring phage defence systems through biochem and structural biology. @NEBiolabs provides an academic research environment with the freedom of industry. Please take a look! 🤓🧫🧬 tinyurl.com/49phcyh6

Rel/Par superfamily toxins have yet another activity - trimming off the 16S rRNA to kill tuberculosis. Thanks again to wonderful collab with @GenevauxPierre and team, out today shorturl.at/Rm8N4 @DurBiol @NEBiolabs @izaakbeck 🤓🎊🎉

Looking for great PhD candidates! Excited to collab with Prof Mark Szczelkun at Bristol UK, studying MADS phage defence. This will be a CASE studentship including research visits to New England Biolabs HQ in MA, USA 🤓 @NEBiolabs shorturl.at/KZGup deadline 3rd Dec

RptR is a new addition to the growing collection of phage defence-associated transcriptional regulators. Congrats to @YugengZ @TangLabOxford @_MarionSchuller @IvanAhelLab and thank you, it was a pleasure to help out the study! @NEBiolabs. academic.oup.com/nar/article/53…

@joeBondyDenomy @DarrenSmithdx @NAR_Open @NEBiolabs @DurBiol Yup great question - working on it!

@BlowerLab @DarrenSmithdx @NAR_Open @NEBiolabs @DurBiol Wow! Congrats. does phage dna get cut during infection? Been so hard to detect for other systems tbh. I am so jealous of Garneau et al 2010

Latest BREX story from the lab - turns out there is a nuclease after all! Congrats to Jenny Readshaw and the whole team, including wonderful collabs Barry Stoddard, Brett Kaiser and @DarrenSmithdx. @NAR_Open @NEBiolabs @DurBiol academic.oup.com/nar/article/53…

We are delighted to host Professor Tim Blower @BlowerLab as keynote speaker to our MID symposium @WarwickLifeSci Date: 20th of June Venue: GLT1 We invite MBio, PhD students and Postdocs to submit abstracts for posters and talks by 11th of June to @CRodriguesLab

For those of you who approached me at @MicrobioSoc #Microbio25 (and anyone else interested!!), this is your last chance to apply for our PDRA position. Come join us in Glasgow!

The post will be based in Ipswich, MA, north of Boston. Non-US citizens welcome (if eligible for a J-1 visa). The focus will be on basic research leading to publications. We provide an academic research and training environment, with >20 research labs.

The lab is now up and running at New England Biolabs @NEBiolabs! I'm looking for a postdoc to study phage defence systems. If you'd like the academic freedom to publish but the resources of industry, then take a look 🤓😃 neb.wd5.myworkdayjobs.com/en-US/NEB_Care…

Super opportunity to join Giusy in Glasgow!

The final version of our Serratia paper is now out! Congrats to @TomCX99 and (X-less) Suraj, and a big thank you to @BlowerLab and @StephenRG97. tinyurl.com/3vnyvufa

Over the moon to share some amazing news—I’ve been awarded an MRC Career Development Award to pursue my research at the University of Glasgow @UofGSii ! 🎉 Can’t wait to get started on this exciting new chapter. Stay tuned—I’ll soon be advertising a PDRA position!

Using cryoEM we understood the structural basis of chiral DNA wrap by bacterial gyrase (and also produced the most complete/highest resolution E coli gyrase model to date). @JohnInnesCentre @DurhamU34989 @MCB_UJ

Thrilled to share my latest postdoc paper published in @NatureComms NTase toxin targeting serine tRNA 3'-ends by CMP addition in M. tuberculosis H37Rv. Thanks to all the co-authors, @GenevauxPierre @BlowerLab @ONeyrolles rdcu.be/dZle4

When experiments don’t work... build a phage costume! 🎃 Happy PHAGEOWEEN!!! 👻🧬#Teamwork

journals.asm.org/doi/10.1128/jv… Our thoughts on how toxins bound to TAs are activated: via conformation changes, not by selective degradation of ATs by a protease (makes little sense since both are structured). Remarkable insights determined by studying various TAs as they inhibit phage.

@crypticprophage Fab - a super minireview! Thanks for including our study

Researchers @blowerlab and colleagues use biochemistry, biophysics, and crystallography to characterize a mechanism of antitoxin induced autophosphorylation that can neutralize nucleotidyltransferase toxins of Mycobacterium tuberculosis nature.com/articles/s4146…

Congratulations to @BlowerLab and @tomarrow234 Happy to be involved in this wonderful collaboration! NTase toxins are truly amazing! Dissecting the antitoxin-mediated Toxin auto-phosphorylation rdcu.be/dSXxi