Ivan Ahel Lab

The first chemical synthesis of ADP-ribosylated oligonucleotides provides powerful tools to study ADP-ribosylation of nucleic acids pubs.acs.org/doi/10.1021/ja…

Learn more about the interplay between ADP-ribosylation and ubiquitination: PARG regulates proteasomal degradation of the ADP-ribosyl hydrolase TARG1 by preventing PAR-dependent ubiquitination mediated by the E3 ligases HUWE1 and TRIP12 sciencedirect.com/science/articl…

The interplay between ADP-ribosylation and ubiquitination, mediated by PARP7 and DTX2 proteins, can serve as a rapid AHR transcription “off-switch” through proteasomal degradation. embopress.org/doi/full/10.10…

Please check our collaborative paper with Marcin Suskiewicz and Sebastien Huet labs on FAM118 proteins – non-canonical sirtuins that form filaments and act as NADases in human and other vertebrate cells. nature.com/articles/s4159…

Here you can read our full review paper on the interplay between ADP-ribosylation and ubiquitination, with special focus on dual, hybrid modification ADPr-Ub: pubmed.ncbi.nlm.nih.gov/41065402/

A few years back we discovered a dual hybrid protein modification composed of an ADP-ribose dinucleotide and the ubiquitin moieties (ADPr-Ub). Here you can read our review that will give you an update on this increasingly popular topic: rdcu.be/eETIT

A few years back we discovered a dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub). Now we reveal that ADPr-Ub can be further ubiquitinated by the E3 ubiquitin ligase RNF114! nature.com/articles/s4146…

The application deadline has been extended for a postdoc position in our lab until August 22. Please enquire/apply if you are interested in ADP-ribosylation, ubiquitination, genome stability or immunity. my.corehr.com/pls/uoxrecruit…

Really thrilled to see our paper out now in @NAR_Open: a new transcriptional repressor, RptR, that regulates type I restriction-modification systems! 🎉 Big thanks to @TangLabOxford, @_MarionSchuller, @IvanAhelLab, and @BlowerLab! doi.org/10.1093/nar/gk…

We have another postdoc position available to work on interplay between ADP-ribosylation and ubiquitination in regulation of genome stability. For this post expertise in cell biology is required. my.corehr.com/pls/uoxrecruit…

Our new paper describing the RNF114 protein as a reader of dual hydrid modification composed of ADP-ribose and ubiquitin (ADPr-Ub) we discovered a few years ago (collaboration with the lab of Gerbrand van der Heden van Noort) biorxiv.org/content/10.110…

A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th. my.corehr.com/pls/uoxrecruit…

Call me a #ubiquitin geek, but this is genuinely one of the most exciting findings in recent years. Only came across Ub—ADPr a few years back with some pioneering @IvanAhelLab papers. New field emerging here, folks!

Our discovery of reversing enzymes for RNA ADP-ribosylation reveals a possible defence protein module against toxic attack pubmed.ncbi.nlm.nih.gov/39970281/

Potential PhD students interested to work in our laboratory are welcome to apply through the ILESLA programme

We are pleased to inform you that the meeting “From Genome Instability to Cancer: A tribute to Angelos Constantinou” that will take place in Carry-Le-Rouet from March 10th to March 13th 2025 is now open for registration on the link: tribute2angelos.fr/page/home/

Our laboratory is looking for a postdoc with expertise in protein biochemistry and structural biology to work on novel pathways regulated by ADP-ribosylation of nucleic acids. Please RT.

Our new paper in collaboration with Luca Palazzo laboratory: authors.elsevier.com/sd/article/S14…

We're in the news. 😊 @JgmRack @IvanAhelLab @LeidenADPr @physorg_com phys.org/news/2024-10-s… doi.org/10.1016/j.jbc.…

Our team in Orléans (France) is looking for a new postdoc, to work closely with a research associate, Ibtissam Talhaoui, on a project focused on potential SUMO E3 ligases targeting the nucleosome. The details here: emploi.cnrs.fr/Offres/CDD/UPR…