Chris Anderson

Among the things hospitals teach you is a deep respect for disease. It is really hard to move the needle. We won't "cure all disease in 10 years". And there's a good change that medicine will still look much the same a decade from now.

#STROKE: In patients with acute ischemic stroke, admission NT-proBNP may predict the in-hospital development of atrial fibrillation detected after stroke (AFDAS), and a threshold of 505 pg/ml confers good discriminatory value. #AHAJournals ahajournals.org/doi/10.1161/ST…

@MariosGeorgakis @dpsg108 @JRosand_MD @drcbanerjee @CDAndersonMD @MuscNeurology Thank you Marios!

Our study in @NephrologyJourn explores the interplay between #CKD and ischemic #stroke. Findings highlight the need for integrated care strategies to improve outcomes and reduce stroke risk in CKD patients. @leonardyeo1 @ClaraNgoh @CDAndersonMD onlinelibrary.wiley.com/doi/full/10.11…

Spatial proteomics in human carotid atherosclerotic plaques (N=118). A great weekend read❗️ 👉subregions isolated with microdissection (lipid core, fibrous cap, tunica media) 👉mass-spec proteomics 👉proteome-defined subclusters across subregions 👉biological enrichment across subclusters 👉associations with instability features 👉predictions of unstable vs. stable plaque 👉correlations with plasma proteome

Thanks Tom. You’ve done so much for the field that I appreciate this tremendously.

Another key resource for CNS genomic and drug target discovery research❗️ 👉pQTLs for 6,361 CSF proteins (SomaScan aptamers) 👉N=3,506 samples 👉3,885 associations for 1,883 proteins 📜paper: nature.com/articles/s4158… 📊summ stats: wustl.app.box.com/s/3kms8fjz228q…

We made a lot of effort to put all summary statistics available. There are in four different places: 1) NIAGADS: dss.niagads.org/collections/kn…, 2) GWAS catalog, GCST90317902–GCST903193033, 3) Pheweb browser ontime.wustl.edu, and 4) our website: neurogenomics.wustl.edu/open-science/r…

You're never behind the genetic 8-ball. Making healthy lifestyle choices reduces your risk of age-related brain disease even if you have a genetic predilection. neurology.org/doi/10.1212/WN…. @BWHNeurology @MGHNeurology @CGM_MGH @broadinstitute

Comprehensive proteome-wide Mendelian randomization for 355 phenotypes in 3 ancestries 👉N=35,559 European, 1,871 African, 1,823 East Asian 👉SomaScan & Olink 👉extensive sensitivity analyses 📊Results browsable here: broad.io/protein_mr_atl… 📰Preprint: medrxiv.org/content/10.110…

I extend my deepest gratitude to my co-authors @rainermpg, @sdorodgar, @VineetRaghu2, @pnatarajanmd, @BellomoTiffany, and @CDAndersonMD for their invaluable contributions, and especially to my PI @MariosGeorgakis for making this possible and for his immense support

Many cool findings & a great resource for future research in atherosclerosis 📊GWAS summ stats to be posted on @GWASCatalog Phenomenal work by star @Murad__Omarov⭐️ Great collaboration with @CDAndersonMD @rainermpg @sdorodgar @VineetRaghu2 @pnatarajanmd @BellomoTiffany

Many thanks to study co-authors @lucidtronix, @ShinoKany, Rahul Mahajan, Clay Turner, @steven_lubitz, @MahnazMaddah and 🙏 as always for mentorship @patrick_ellinor, @CDAndersonMD @broadinstitute @MGHHeartHealth @MassGeneralNews

🚨Postdoc Opening🚨 We're seeking a skilled scientist to lead research in multiomics❗️ Join our excellent interdisciplinary team👇in our efforts to tackle pressing challenges in cardiovascular disease Lab: georgakis-lab.isd-muc.de Position: findapostdoc.com/search/Job-Det… Please RT!

- While the protective role of GFAT on CVD risk is mediated predominantly by common vascular risk factor modification (SBP, T2DM, LDL), residual mediatory effect may be exerted by adipose-specific factors, suggesting that targeting those may provide additional vascular benefit

The effects of a polygenic risk score for BMI on obesity and obesity-related morbidities are offset by a healthy lifestyle 🧬🍲🏃‍♀️ 👉evidence of additive & multiplicative interaction 👉high PRS ⬆️ the effect of unhealthy lifestyle on obesity risk sciencedirect.com/science/articl…

@MIT_CSAIL @gp_pulipaka T-shirt material. Happy place.

9 Distance Measures in data science with algorithms (v/@gp_pulipaka).

Honored to have you join the faculty Priya. Great things now and ahead.

GWAS of 2024 AI-derived (mainly imaging) human disease endophenotypes, including genetic correlations and Mendelian randomization associations with disease endpoints🧬 Summary stats to be made available upon publication medrxiv.org/content/10.110…

Excited to share our study investigating the genetics of combined lipid patterns led by @tgillilandmd @jsdron! ahajournals.org/doi/10.1161/CI… @CircRes [1/8]