Circulation Research

Lin & colleagues identify #ATAD3A as a protective regulator that helps prevent aortic #aneurysm & dissection by controlling communication between mitochondria & lysosomes & limiting copper-related vascular cell injury. Learn more at ahajrnls.org/3SMqYiV

Liu & colleagues found that after a heart attack reducing #Piezo1 activity in myeloid cells enhances clearing dead cells, leading to improved cardiac repair & reduced #fibrosis. Learn more at ahajrnls.org/4yhSCV5

Moss & colleagues found that inhibition of #Vegfr3 impairs lymphatic function and exacerbates hypoxia-induced #PH. Learn more at ahajrnls.org/4aLw6Kf @KeYuan_BCH @Joseph_C_Wu @marknicolls

@BenHegyi et al found the small peptide inhibitor #FixR corrects the leaky voltage-gated sodium channels in #HF providing mechanistic insights into channel dysfunction & novel #antiarrhythmic approaches. Learn more at ahajrnls.org/4wunIag @kbedi88

ICYMI: The latest episode of DiscoverCircRes podcast bit.ly/3SjsvfV @StHilaireLab chats w/ @Beichensun95, R. Gogiraju, & K. Schaefer about their study Chronic Erythrocyte NO Production Accelerates Atherosclerosis by Increasing SMC De Novo Lipogenesis

Karnes & colleagues identify #SNX29 as a potential genetic driver of vasodilator-responsive #PAH, linking a variant to increased expression & greater clinical response. Learn more at ahajrnls.org/4yqB5u2 @jasonkarnes

@VirginiaSHahnMD et al found examining individual cells from human heart tissue, distinct abnormalities in cardiomyocytes, fibroblasts, immune, & vascular cells in #HFpEF. Learn more at ahajrnls.org/4wpTpRZ @patrick_ellinor @KSharmaMD @kbedi88

Check out the latest review in the July 6th issue of @CircRes by Kashanias & colleagues "#Myovascular Niche: The Role of #EndothelialCells in Skeletal Muscle Health and Disease" at ahajrnls.org/4p5LE12

@sivareddykotla et al show #LATS1/2–#CD38 axis promotes formation of fragile, leaky neovessels that drive intraplaque hemorrhage & organized #thrombosis in advanced human #atherosclerosis ahajrnls.org/4y45Btl @CraigMorrell5 @jmartinlab @anita_deswal @PalaskasN

Sun & colleagues identify a protein, #SBK2, as a vital guardian of #mitochondria in the heart. Learn to protect cardiac function and prevent #HeartFailure against pressure-overload stress at ahajrnls.org/4vewh8i

@CircRes July 6th Issue is Out! ahajrnls.org/3wPOBJJ Cover: SBK2 ablation exacerbates mitochondrial collapse in cardiomyocytes & precipitates heart failure, as SBK2 physiologically governs NDUFV1 import to sustain mitochondrial complex I activity.

Ibikunle et al found #VSMCs, rather than immune cells, are the primary source of #atherosclerotic foam cells that clog #arteries during #HeartDisease. Learn more at ahajrnls.org/4ePTyHb @egarcia_MD_PhD @acbashore @molvascular @RobertCBauer @coronel_johis

Yang & colleagues demonstrated that restoring the impaired coupling of the #TRPV4-#KCa2.3 complex in #ECs serves as an effective therapeutic strategy for #PH. Learn more at ahajrnls.org/4eBMyz6

Krstevski & colleagues reveal key #TFs that drive cardiac #fibrosis, identifying new potential therapeutic targets for treating #HeartFailure. Learn more at ahajrnls.org/4wjzjZT @CrisdionKrstev1 @drdandonner @CharlieCohenPhD @taylahgaynor

ICYMI: The latest episode of DiscoverCircRes podcast bit.ly/3SjsvfV @StHilaireLab chats w/ @Beichensun95, R. Gogiraju, & K. Schaefer about their study Chronic Erythrocyte NO Production Accelerates Atherosclerosis by Increasing SMC De Novo Lipogenesis

Check out the latest review in the June 19th issue of @CircRes by Hayek & colleagues "uPAR/suPAR Signaling and Organ Crosstalk in Cardiovascular-Kidney-Metabolic Syndrome" at ahajrnls.org/4oPQFux @salimhayek

Atici et al found impaired #NAD+-#SIRT1 axis in the pathogenesis of #Kawasaki disease #vasculitis. Learn about the therapeutic potential of targeting this to reduce #CV lesions & #inflammation at ahajrnls.org/4uYytk3 @Asliekinatici @magalinoval @ThasssioMesquita

Dong & colleagues found a bioactive hormone derived from #adipose tissue (#FAM19A5), inhibits vascular #calcification & #osteoporosis in a mouse model. Learn more at ahajrnls.org/44s26PI

Song & colleagues found #mRNA delivery of an activated platelet-specific anti-GPIIb/IIIa scFv enables in vivo #antithrombotic protection without affecting #hemostasis. Learn more at ahajrnls.org/4uVys0m @DrXiaoweiWang

Kowalski et al found #potassium deprivation is a powerful stimulus for kidney Na retention in humans which, in the long term, may promote #hypertension & have adverse #CV effects. Learn more at ahajrnls.org/4g06EUO @Sweis_NWG @Dan_Batlle