Circulation Research

Tikhomirov et al found two #mRNAs that partly mediate the #fibrosis process driven by #IL11 & could potentially be measured in blood to detect fibrosis in the #heart at an earlier stage. Learn more at ahajrnls.org/4cSlHMM @benrod91 @dr_m_sweeney @JoeOkaforCardio

Wang & colleagues found that the protein #Chmp4b builds & maintains #Ttubules in #heart, & that its dysfunction disrupts heart function & is linked to #HF. Learn more at ahajrnls.org/4cY6hXt @LongShengSong1 @0623659 @zju.edu.cn

Yoon & colleagues found that the secreted glycoprotein #VEGF-D enhanced endothelial barrier function & conferred protection against #inflammatory in acute #lung injury models. Learn more at ahajrnls.org/4cFUbn4 @kaminskimed

Chen & colleagues found that #acetate is a negative regulator of #platelet hyperactivity & #thrombus formation in #hypertension. Learn more at ahajrnls.org/4tJxEMc @yufeichen

@CircRes is grateful to Dr. Eugene Braunwald (August 1929-April 2026) for his many contributions to the journal, including the Aug 13, 2013 Heart Failure Compendium: ahajrnls.org/4dda7gC

@CircRes honors the life & legacy of pioneering Editorial Board Member and former Guest Editor, Dr. Eugene Braunwald for his groundbreaking work in #HCM. ahajrnls.org/4w1rlFq

Witmer & colleagues found a previously unrecognized regulatory pathway, in which alternative processing of the #SCN5A gene produces a #mitochondrial protein that influences cardiac energy production. Learn more at ahajrnls.org/4mZ4g23 @TheElrodLab

@MaartjeWesthoff & colleagues found that #PTEN inhibition reduces cardiac #fibrosis caused by #AngII. Learn how to fight fibrosis from #hypertension at ahajrnls.org/48mGSFv @RoseEDixon1

Froese & colleagues found that #mitochondrial motility mediated by #RHOT proteins determines intracellular mitochondrial localization & is critical for #cardiomyocyte maturation. Learn more at ahajrnls.org/3OBtQxf @JBauersachsMD @rog @IntmedAbel

Zhang et al demonstrate that removal of #Alk1 in #AECs of the mouse establishes a preclinical model of hereditary hemorrhagic telangiectasia (#HHT). Learn more about the mechanism of severe #nosebleeds at ahajrnls.org/4vOh6nH @mf_navedo @_kyleJacobs @PengHeAtlas

@CircRes April 24th Issue is Out! ahajrnls.org/4lDzN86 Cover: A vascular image of cortical surface from a mouse with Alk1 gene deletion in arterial endothelial cells (magenta), while the rest of the vasculature (capillaries, and veins) is in green.

@CircRes Compendium on Migration of #Mitochondria Beyond Cell Boundary Clotting the Gap Between Mitochondria-Mediated Immunity and Mitochondrial Transfer ahajrnls.org/4e1hzfY Authored by Drs. Tupin & colleagues.

@CircRes Compendium on Migration of #Mitochondria Beyond Cell Boundary Mitochondrial Transfer to #ECs: Mechanisms, Evidence, and Therapeutic Potential ahajrnls.org/3OPG8lF Authored by Drs. Im & Melero-Martin @meleromartinlab

@CircRes Compendium on Migration of #Mitochondria Beyond Cell Boundary Mitochondrial Transfer: From Bench to Bedside ahajrnls.org/4cxk6fc Authored by Drs. Ikeda & colleagues. @gentaro_ikeda

4/4 And the April 10th issue is the Compendium on Mitochondria bit.ly/3PM5dOu

3/4 Parathyroid Hormone Contributes to Pulmonary Hypertension in Hypoxic Conditions by Joki et al bit.ly/4v670xU

1/4 New @CircRes podcast #DiscoverCircRes bit.ly/3OKC6uP @StHilaireLabchats with @HanqiangD and Martin Schwartz about their study FOXO1 Integrates Endothelial Hemodynamic, Inflammatory and Metabolic Pathways in Atherosclerosis bit.ly/47xETOm

@CircRes Compendium on Migration of #Mitochondria Beyond Cell Boundary Intercellular Mitochondrial Transfer: Implications in Cardiovascular Health ahajrnls.org/4sEMiCR Authored by Drs. Wang & Tian.

@CircRes Compendium on Migration of #Mitochondria Beyond Cell Boundary @HinaLateef et al Research Letter "#SARM1 Regulates #BNIP3-Mediated Mitochondrial Quality Control in #Diabetic #Hearts " ahajrnls.org/41qYlZA @ChiFungLeePhD @AnnChiaoPhD @SinghalPraty