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What happens to our blood as we get older? I am very excited to share our preprint and key findings below
biorxiv.org/content/10.110…
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Emily Mitchell
38 posts
Emily Mitchell
@Emily_LMitchell
PhD student @sangerinstitute | Haematology trainee @CUH_NHS | Ageing, blood, somatic evolution.
انضم Ağustos 2021
137 يتبع235 المتابعون
Emily Mitchell أُعيد تغريده
I am pleased to announce our latest paper.
We report results from single cell RNA and TCR sequencing, alongside spatial RNA and genome sequencing across different regions of kidney cancers:
cell.com/cancer-cell/fu…
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@jyoti_nangalia @Nature @sangerinstitute @SCICambridge @Cambridge_Uni Huge congrats Jyoti! Such fascinating insights and pioneering work to develop this approach :)
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Emily Mitchell أُعيد تغريده
Delighted to share my research group's latest study, published today @Nature 👉nature.com/article/s41586… where we trace the life histories of blood cancer development in patients @sangerinstitute @SCICambridge @Cambridge_Uni
Wellcome Sanger Institute@sangerinstitute
The mutations that cause adult blood cancer can occur as early as childhood or even in the womb 🩸 #BloodCancer #Genomics Read the full story ➡️ sanger.ac.uk/news_item/adul…
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@SteveStuWill That’s amazing - almost as good as the African grey parrot
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Emily Mitchell أُعيد تغريده
Great work Phil, Tim and Claire - fascinating findings... happy to have been able to make a small contribution!
Philip Robinson@drphilrobinson
Delighted to share our paper ➡️Increased somatic mutation burdens in normal human cells due to defective DNA polymerases go.nature.com/3kUQVJy Implications for our understanding of cancer risk and the somatic mutation theory of #ageing 🧵⬇️
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Emily Mitchell أُعيد تغريده
To celebrate #WorldLymphomaDay2021 we wanted to share this recent ACT webinar with @CUH_NHS Haematology consultant, Dr George Follows, on his research into Hodgkin Lymphoma treatments 👇👀 helpyourhospital.co.uk/worldlymphomad… #WLAD2021
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How does a single cell generate different organs and tissues of the human body? Do early cells contribute equally? Do embryonic patterns differ between people? Sequencing normal cells reveals the developmental stories hidden in their DNA @NaturePortfolio nature.com/articles/s4158…
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Beautiful work and tweetorial
Alex Cagan@ATJCagan
Thrilled to share our paper on the mutational landscape of human somatic and germline cells @Nature. We integrated histology and genomics to explore the genetic diversity that develops within our bodies as we age. nature.com/articles/s4158… An illustrated tweetorial… [1/15]
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@FrancescoMaura4 @R_Rahbari @Nature @luiza_moore @ATJCagan @TimCoorens Huge congratulations all - what a fantastic achievement!
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@R_Rahbari @Nature Congratulation @R_Rahbari
@luiza_moore @ATJCagan @TimCoorens and team
for this massive effort!
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Excited to share our work out today in @Nature nature.com/articles/s4158…
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@doctor_msc @biorxivpreprint Thanks Mike - really enjoyed working on this fascinating project together :)
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Really exciting paper out on @biorxivpreprint, lead by my v talented colleague @Emily_LMitchell
If you have any interest in clonal haem or ageing - a must read! 3500 genomes from 10 individuals gives remarkable (& sometimes alarming) insights into what happens to blood as we age
Emily Mitchell@Emily_LMitchell
What happens to our blood as we get older? I am very excited to share our preprint and key findings below biorxiv.org/content/10.110…
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@MunshiPashna Agree! I think staying fit, healthy and happy over a lifetime could make a difference... but anyone can also be unlucky with the timing and identity of variants they by chance acquire
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@Emily_LMitchell Congratulations on your work! Would be very interested to see if same holds true in elderly “fit” patients - those working out/performing cardiovascular activity routinely.
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What happens to our blood as we get older? I am very excited to share our preprint and key findings below
biorxiv.org/content/10.110…
English
@DrHelenOram @doctor_msc @tinynerdster @Tom_J_Mitchell @heatherEmachado @scienceadvocacy @imartincorena @KSaebParsy @jyoti_nangalia @sangerinstitute @SCICambridge Thanks very much Helen!
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@Emily_LMitchell @doctor_msc @tinynerdster @Tom_J_Mitchell @heatherEmachado @scienceadvocacy @imartincorena @KSaebParsy @jyoti_nangalia @sangerinstitute @SCICambridge This is great Emily
Congratulations
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Want to learn about clonal #evolution in our #blood as we age? Check out this exciting new preprint from @Emily_LMitchell and team. Proud to have been a (very small) part of it.
Emily Mitchell@Emily_LMitchell
What happens to our blood as we get older? I am very excited to share our preprint and key findings below biorxiv.org/content/10.110…
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@tubedonmars I wouldn't predict therapeutic plasma exchange should have a significant effect on the somatic evolutionary processes we have observed (unless removing proinflammatory cytokines in a chronic disease state)
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@Emily_LMitchell How would you say the findings from your study support interventional therapies such as TPE (Therapeutic Plasma Exchange)?
Wan Chai District, Hong Kong 🇭🇰 English
@Emily_LMitchell Impressive work Emily! Congratulation and glad to finally read (likely multiple times) your amazing work!
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@eirinipapapetr1 We have unpublished data showing that chemotherapy can dramatically bring forward the transition to oligoclonality by significantly altering fitness effects of variants
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@Emily_LMitchell Congratulations for this fascinating study and great tweetorial! What are the implications of this modeling of constant population size and muts for cell intrinsic vs extrinsic determinants of CH?
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