Tim Coorens

Very happy and excited to announce that I'll be starting my own research group at @emblebi! The group will focus on lineage tracing, somatic evolution and the origins of cancer. Interested in doing a postdoc in the group or know someone who is? Please reach out!

@DannGuerreroR Thanks very much @DannGuerreroR!

Very relevant and beautiful work @TimCoorens! Congratulations!

🧬 The SMaHT marker paper is now live in @Nature This landmark study characterizes somatic variation across 19 tissue types from 150 nondiseased donors, laying the groundwork for future discoveries in health, aging, and disease. Read the full paper: nature.com/articles/s4158…

Last but not least, if you're interested in somatic mutations, new technologies and computational genomics - we're hiring a postdoc in my brand new lab @emblebi! Reach out if interested or you have any questions, and apply here: embl.wd103.myworkdayjobs.com/en-US/EMBL/job…

This effort would be impossible without the work of many hundreds of people, including the scientists, the NIH staff, and - of course - the donors and their family. A very exciting time to study somatic evolution and I can't wait to see what the next years bring.

The cells in our bodies constantly acquire mutations. But what are the patterns of mutations across tissues? How do mutations in normal cells lead to disease? These and other questions we will tackle within the SMaHT Network, now described in @Nature nature.com/articles/s4158…

@EricTopol @Nature Thanks for highlighting the SMaHT effort @EricTopol! Fantastically exciting project, immensely grateful to be part of it and can't wait to see what the next few years hold.

We are all somatic mutation mosaics. "There are trillions of cells in a human body and so the total number of somatic mutations acquired in a single individual may well exceed quadrillions, millions of times the size of the human genome." @Nature nature.com/articles/s4158…

@Noelia__DF @MobileGenomes @emblebi Thanks very much for the kind words, @Noelia__DF! Very much enjoyed my days in Santiago

@MobileGenomes @TimCoorens @emblebi Such a nice talk, @TimCoorens! It's not only the brilliant research, but your contagious enthusiasm about it. It has been really inspiring and definitely a motivation to start the week. Good luck with the upcoming projects. Waiting for the new paper on Thursday! Enjoy Santiago!

This Monday at CIMUS @TimCoorens from @emblebi

Thrilled to see #SAVANA out in @naturemethods🥳 SAVANA detects haplotype-resolved somatic SVs and copy number aberrations (SCNAs) and infers tumour purity & ploidy in clinical samples using long-read sequencing with or WITHOUT a matched germline control 👇nature.com/articles/s4159…

1/ 🧵Check out our new study in @NatureGenet, which examines how precancerous conditions (MGUS/SMM) evolve into Multiple Myeloma, and offers new computational methods to predict progression risk and model cancer evolution. doi.org/10.1038/s41588…

Call for Papers! @genomeresearch is now encouraging submissions for a Special Issue on The Genetics and Genomics of Somatic Mosaicism, Guest Edited by Drs. @giladevrony, @EAliceLee2, and @R_Rahbari. tinyurl.com/Call-for-paper… #BOG25 #KSMosaicism25 #MITS25 #somaticmosaicism

Check out our new paper in @nature nature.com/articles/s4158…. We report genetic mechanisms of neural tube defects in patients. Spina bifida is also known as meningomyelocele (MM). Prior family-based and association studies found few linked genes, so we took a different approach.

@GiovannaMantica Thanks very much, Giovanna!

Came across this nature.com/articles/d4158… during my usual Monday morning tea + News & Views scrolling – great to see this paper out with the attention it deserves! Congrats to @TimCoorens and the entire team!

This new paper @Nature today on the genesis and evolution of stomach cancer goes against the alt-model nature.com/articles/s4158… nature.com/articles/d4158…

For the first time, scientists have analysed mutations in stomach lining tissue to reveal the earliest stages of cancer. The team also uncovered a potential new cause of stomach cancer, which needs further research 🔎 sanger.ac.uk/news_item/earl…