Fraternali Lab

New paper alert! 🚨

Dongjun & Joseph at #bsi2025 with poster on this! Poster P005

Also check out UCL press release: ucl.ac.uk/life-sciences/…

Belated announcement that ImmunoMatch has now been published in @naturemethods !🎉 AI powered prediction of antibody heavy-light chain pairing with applications in understanding B cell biology and mAb discovery. nature.com/articles/s4159…

@ffrancafrat @3DSIG_ISCB @iscb

@ffrancafrat to deliver keynote in the #3DSIG track #ISMBECCB2025 In Liverpool this year! linkedin.com/posts/rgonzalo…

Great talks by both Oriol and Joseph at #ELIXIR #3dBioinfo meeting at Barcelona!

Another preprint @FraternaliLab: We explored how the antibody framework (i.e. parts of variable region away from Ab-Ag interface) can be exploited to fine-tune antibody effector functions. V enjoyable in vitro/in silico collab @ffrancafrat @SophiaKaragiann biorxiv.org/content/10.110…

🚨 New preprint on our new approach (IndeLLM) to score pathogenicity of insertions/deletions biorxiv.org/content/10.110…

Happy to share new work @FraternaliLab led by @Dongjun_Guo - exploring how antibody heavy and light chains form specific pairs. We fine-tuned an antibody language model to predict pairing, and asked how pairing propensities change during B cell maturation and in diseases.

Proud to be part of this exceptional mentoring programme💪 @ELIXIREurope

@ffrancafrat speaking in Copenhagen today about ongoing work on antibodies in the group!

Joseph on sciCSR to study and infer class switching dynamics in B cells using scRNA-seq data #ISMB2024

Dongjun's talk on ImmunoMatch a.k.a. antibody "tinder" to study heavy and light chain pairing at 3DSIG! #ISMB2024

Oriol's talk on addressing biases in variant impact prediction at VarI #ISMB2024

Congratulations to Guillem for winning a prize for his poster on double negative/atypical memory B cells in SARS-CoV-2 mRNA vaccination at the @iit_ucl symposium 2024 🎉👏

We present VCAb, a new web interface for performing different structure-based explorations towards aspects of antibody engineering: 🧵(1/7) 📄biorxiv.org/content/10.110… 🌐fraternalilab.cs.ucl.ac.uk/VCAb/

Postdoc available in our lab. B cells, antibodies and class switching. Part of a wider BBSRC sLoLa with @FraternaliLab @Mauri_group jobs.surrey.ac.uk/Vacancy.aspx?r…

Well done to Izzy for winning a prize for her presentation on the single cell analysis of B cells in lung cancer!!👏🫁🧬#WIRM

Xmas gift 🎁 came early for us: New review came out on @COSB_CRSB where we talked about structures of different antibody isotypes & how to model and study them! Feat. a great deal of fun drawing antibodies in the style of ladders and snakes! Free access at authors.elsevier.com/c/1iHZn,LqArQC…

Xmas outing feat. a walk across Hertfordshire countryside on a cold wintery day followed by pub!